TRT Alignment For SR1 Cosmics and Beyond

We present an algorithm for the alignment of the ATLAS Inner Detector, developed for the analysis of cosmics data taken with the ID barrel in SR1 in the summer of 2006. Our results include a comparison of the relative SCT-TRT alignment with survey measurements, a study of the alignment of SCT and TRT module positions and TRT module deformations, and a comparison of the `local' and `global' methods for alignment

Reducing the role of random numbers in matching algorithms for school admission

New methods for solving the college admissions problem with indifference are presented and characterised with a Monte Carlo simulation in a variety of simple scenarios. Based on a qualifier defined as the average rank, it is found that these methods are more efficient than the Boston and Deferred Acceptance algorithms. The improvement in efficiency is directly related to the reduced role of random tie-breakers. The strategy-proofness of the new methods is assessed as well

Alignment of LHCb tracking stations with tracks fitted with a Kalman filter

The LHCb detector, operating at the Large Hadron Collider at CERN, is a single arm spectrometer optimized for the detection of the forward b anti-b production for b physics studies. The reconstruction of vertices and tracks is done by silicon micro-strips and gaseous straw-tube based detectors. In order to achieve good mass resolution for resonances the tracking detectors should be aligned to a precision of the order of ten microns. A software framework has been developed to achieve these goals and has been tested in various configurations. After a description of the software, we present alignment results and show in particular for the first time that a global $\chi^2$ solving for alignment using a locally parameterized track trajectory can be achieved

The global covariance matrix of tracks fitted with a Kalman filter and an application in detector alignment

We present an expression for the covariance matrix for the set of state vectors describing a track fitted with a Kalman filter. We demonstrate that this expression facilitates the use of a Kalman filter track model in a minimum $\chi^2$ algorithm for the alignment of tracking detectors. We also show that it allows to incorporate vertex constraints in such a procedure without refitting the tracks.Comment: 17 pages, 4 figure

First studies of T-station alignment with simulated data

The alignment of the tracking stations using tracks fitted using standard LHCb track fit is studied. The procedure is presented together with two examples using simulated data. The first scenario presents the alignment of the IT and OT layers using beam-gas events at 450~GeV with no magnetic field. The second scenario is the alignment of the OT layers and IT boxes, layers and ladders with magnet-on data using minimum bias events at nominal energy. The results are validated by refitting J/$\psi$ tracks using the misaligned geometry compared to the re-aligned case as well as the default. It is shown that after alignment the J $\psi$ mass resolution is degraded by at most 3~\%

Curcumin as Treatment for Bladder Cancer : A Preclinical Study of Cyclodextrin-Curcumin Complex and BCG as Intravesical Treatment in an Orthotopic Bladder Cancer Rat Model

Objective. To evaluate the antitumor effect of cyclodextrin-curcumin complex (CDC) on human and rat urothelial carcinoma cells in vitro and to evaluate the effect of intravesical instillations of CDC, BCG, and the combination in vivo in the AY-F344 orthotopic bladder cancer rat model. Curcumin has anticarcinogenic activity on urothelial carcinoma and is therefore under investigation for the treatment of non-muscle invasive bladder cancer. Curcumin and BCG share immunomodulating pathways against urothelial carcinoma. Methods. Curcumin was complexed with cyclodextrin to improve solubility. Four human urothelial carcinoma cell lines and the AY-27 rat cell line were exposed to various concentrations of CDC in vitro. For the in vivo experiment, the AY-27 orthotopic bladder cancer F344 rat model was used. Rats were treated with consecutive intravesical instillations of CDC, BCG, the combination of CDC+BCG, or NaCl as control. Results. CDC showed a dose-dependent antiproliferative effect on all human urothelial carcinoma cell lines tested and the rat AY-27 urothelial carcinoma cell line. Moreover, intravesical treatment with CDC and CDC+BCG results in a lower percentage of tumors (60% and 68%, respectively) compared to BCG (75%) or control (85%). This difference with placebo was not statistically significant (p=0.078 and 0.199, respectively). However, tumors present in the placebo and BCG-treated rats were generally of higher stage. Conclusions. Cyclodextrin-curcumin complex showed an antiproliferative effect on human and rat urothelial carcinoma cell lines in vitro. In the aggressive orthotopic bladder cancer rat model, we observed a promising effect of CDC treatment and CDC in combination with BCG.Peer reviewe