47 research outputs found
Object unified identifier method in logistics resource integration
Purpose: The status which many programs for the object identifier are not incompatible with
each other has become a bottleneck for integrating logistics resources. Scholars have done
some relevant studies in terms of coding and conversion mechanisms, but the problem still
has not got a better solution. The purpose of this study is to research how to make the object
identifier programs compatible.
Design/methodology/approach: Author proposed an object unified identifier (OUID)
method based on OID and introduced the standard identification code in it, according to the
problems of the object identifier in logistics resource integration. And the paper further
designed the acquisition process of the resource basic information and location information,
and analyzed the application environment of object unified identifier based on OID.
Findings: OUID made up for the lack of location information in conversion mechanism, and
avoided to promote new unified identifier standards at the same time. The supplement of the
application environment provided an important support to solve the problems of poor
communication caused by non-unified object identifier in the process of logistics resource
integration.
Originality/value: Using this method, each identification system not only can keep its own
territory, but also can compatible with other object identifiers.Peer Reviewe
Ceramide in cerebrovascular diseases
Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated with a variety of brain disorders. Cerebrovascular diseases, which are mainly caused by abnormal cerebral blood flow and secondary neurological injury, are the leading causes of death and disability worldwide. There is a growing body of evidence for a close connection between elevated ceramide levels and cerebrovascular diseases, especially stroke and cerebral small vessel disease (CSVD). The increased ceramide has broad effects on different types of brain cells, including endothelial cells, microglia, and neurons. Therefore, strategies that reduce ceramide synthesis, such as modifying sphingomyelinase activity or the rate-limiting enzyme of the de novo synthesis pathway, serine palmitoyltransferase, may represent novel and promising therapeutic approaches to prevent or treat cerebrovascular injury-related diseases
Quantitative Measurements of Enlarged Perivascular Spaces in the Brain are Associated with Retinal Microvascular Parameters in Older Community-Dwelling Subjects
Background Perivascular Spaces (PVS) become increasingly visible with advancing age on brain MRI, yet their relationship to morphological changes in the underlying microvessels remains poorly understood. Retinal and cerebral microvessels share morphological and physiological properties. We compared computationally-derived PVS morphologies with retinal vessel morphologies in older people. Methods We analysed data from community-dwelling individuals who underwent multimodal brain MRI and retinal fundus camera imaging at mean age 72.55 years (SD=0.71). We assessed centrum semiovale PVS computationally to determine PVS total volume and count, and mean per-subject individual PVS length, width and size. We analysed retinal images using the VAMPIRE software suite, obtaining the Central Retinal Artery and Vein Equivalents (CRVE and CRAE), Arteriole-to-Venule ratio (AVR), and fractal dimension (FD) of both eyes. We investigated associations using general linear models, adjusted for age, gender, and major vascular risk factors. Results In 381 subjects with all measures, increasing total PVS volume and count were associated with decreased CRAE in the left eye (volume β=−0.170, count β=−0.184, p<0.001). No associations of PVS with CRVE were found. The PVS total volume, individual width and size increased with decreasing FD of the arterioles (a) and venules (v) of the left eye (total volume: FDa β=−0.137, FDv β=−0.139, p<0.01; width: FDa β=−0.144, FDv β=−0.158, p<0.01; size: FDa β=−0.157, FDv β=−0.162, p<0.01). Conclusions Increase in PVS number and size visible on MRI reflect arteriolar narrowing and lower retinal arteriole and venule branching complexity, both markers of impaired microvascular health. Computationally-derived PVS metrics may be an early indicator of failing vascular health and should be tested in longitudinal studies.fals