Active Two-dimensional Steering of Radiation from a Nano-Aperture

We experimentally demonstrate control over the direction of radiation of a beam that passes through a square nano-aperture in a metal film. The ratio of the aperture size and the wavelength is such that only three guided modes, each with different spatial symmetries, can be excited. Using a spatial light modulator, the superposition of the three modes can be altered, thus allowing for a controlled variation of the radiation pattern that emanates from the nano-aperture. Robust and stable steering of 9.5 degree in two orthogonal directions was achieved

Geometric interpretation of the Pancharatnam connection and non-cyclic polarization changes

If the state of polarization of a monochromatic light beam is changed in a cyclical manner, the beam acquires-in addition to the usual dynamic phase-a geometric phase. This geometric or Pancharatnam-Berry phase equals half the solid angle of the contour traced out on the Poincaré sphere. We show that such a geometric interpretation also exists for the Pancharatnam connection, the criterion according to which two beams with different polarization states are said to be in phase. This interpretation offers what is to our knowledge a new and intuitive method to calculate the geometric phase that accompanies non-cyclic polarization changes. © 2010 Optical Society of America

Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease

Introduction: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are the most common types of early-onset dementia. Early differentiation between both types of dementia may be challenging due to heterogeneity and overlap of symptoms. Here, we apply resting state functional magnetic resonance imaging (fMRI) to study functional brain connectivity differences between AD and bvFTD. Methods: We used resting state fMRI data of 31 AD patients, 25 bvFTD patients, and 29 controls from two centers specialized in dementia. We studied functional connectivity throughout the entire brain, applying two different analysis techniques, studying network-to-region and region-to-region connectivity. A general linear model approach was used to study group differences, while controlling for physiological noise, age, gender, study center, and regional gray matter volume. Results: Given gray matter differences, we observed decreased network-to-region connectivity in bvFTD between (a) lateral visual cortical network and lateral occipital and cuneal cortex, and (b) auditory system network and angular gyrus. In AD, we found decreased network-to-region connectivity between the dorsal visual stream network and lateral occipital and parietal opercular cortex. Region-to-region connectivity was decreased in bvFTD between superior temporal gyrus and cuneal, supracalcarine, intracalcarine cortex, and lingual gyrus. Conclusion: We showed that the pathophysiology

Homologous recombination deficiency and cyclin E1 amplification are correlated with immune cell infiltration and survival in high-grade serous ovarian cancer

Background: How molecular profiles are associated with tumor microenvironment (TME) in high-grade serous ovarian cancer (HGSOC) is incompletely understood. Therefore, we analyzed the TME and molecular profiles of HGSOC and assessed their associations with overall survival (OS). Methods: Patients with advanced-stage HGSOC treated in three Dutch hospitals between 2008–2015 were included. Patient data were collected from medical records. BRCA1/2 mutation, BRCA1 promotor methylation analyses, and copy number variations were used to define molecular profiles. Immune cells were assessed with immunohistochemical staining. Results: 348 patients were categorized as BRCA mutation (BRCAm) (BRCAm or promotor methylation) (30%), non-BRCA mutated HRD (19%), Cyclin E1 (CCNE1)-amplification (13%), non-BRCAmut HRD and CCNE1-amplification (double classifier) (20%), and no specific molecular profile (NSMP) (18%). BRCAm showed highest immune cell densities and CCNE1-amplification lowest. BRCAm showed the most favorable OS (52.5 months), compared to non-BRCAmut HRD (41.0 months), CCNE1-amplification (28.0 months), double classifier (27.8 months), and NSMP (35.4 months). Higher immune cell densities showed a favorable OS compared to lower, also within the profiles. CD8+, CD20+, and CD103+ cells remained associated with OS in multivariable analysis. Conclusions: Molecular profiles and TME are associated with OS. TME differs per profile, with higher immune cell densities showing a favorable OS, even within the profiles. HGSOC does not reflect one entity but comprises different entities based on molecular profiles and TME

Phase Singularities Of The Coherence Functions In Young\u27S Interference Pattern

The phase singularities of the coherence functions in Young\u27s interference pattern were analyzed. It was shown that the spectral degree of coherence possesses phase singularities on certain surfaces in the region of superposition. The results of the experiments extend the field of singular optics to the study of phase singularities of correlation functions

Coherence modification and phase singularities on scattering by a sphere:Mie formulation

When light that is spatially partially coherent, such as sunlight, is incident on a sphere, the scattered field exhibits surprising coherence properties. The observed oscillatory behavior with deep minima means that the field in certain pairs of directions is highly correlated, whereas in others, it is essentially uncorrelated, and can even have correlation singularities. Because any subsequent scattering event is strongly affected by the state of coherence, these results are particularly important for multiple scattering in discrete disordered media

The pancharatnam-berry phase for non-cyclic polarization changes

We present a setup that allows the observation of linear, nonlinear and singular behavior of the geometric phase that accompanies non-cyclic polarization changes