2,122 research outputs found
Simulating the Performance of Large-Format Submillimetre Focal-Plane Arrays
A robust measurement of the clustering amplitude of the sub-mm population of
starburst galaxies requires large-area surveys (>> 1 deg^2). The largest-format
arrays subtend only 10 arcmin^2 on the sky and hence scan-mapping is a
necessary observing mode. Providing realistic representations of the
extragalactic sky and atmosphere, as the input to a detailed simulator of the
telescope and instrument performance, allows important decisions to be made
about the design of large-area fully-sampled surveys and observing strategies.
In this paper we present preliminary simulations that include detector noise,
time-constants and array geometry, telescope pointing errors, scan speeds and
scanning angles, sky noise and sky rotation.Comment: 3 pages, 3 figures, Conference Contribution: 2K1BC Workshop
"Experimental Cosmology at millimetre wavelengths", July 9-13 2001, Ital
Nanoscale-length control of the flagellar driveshaft requires hitting the tethered outer membrane
The bacterial flagellum exemplifies a system where even small deviations from the highly regulated flagellar assembly process can abolish motility and cause negative physiological outcomes. Consequently, bacteria have evolved elegant and robust regulatory mechanisms to ensure that flagellar morphogenesis follows a defined path, with each component self-assembling to predetermined dimensions. The flagellar rod acts as a driveshaft to transmit torque from the cytoplasmic rotor to the external filament. The rod self-assembles to a defined length of ~25 nanometers. Here, we provide evidence that rod length is limited by the width of the periplasmic space between the inner and outer membranes. The length of Braun's lipoprotein determines periplasmic width by tethering the outer membrane to the peptidoglycan layer
Randomized phase II study investigating pazopanib versus weekly paclitaxel in relapsed or progressive urothelial cancer
Purpose:
Two previous single-arm trials have drawn conflicting conclusions regarding the activity of pazopanib in urothelial cancers after failure of platinum-based chemotherapy.
Patients and Methods:
This randomized (1:1) open-label phase II trial compared the efficacy of pazopanib 800 mg orally with paclitaxel (80 mg/m2 days 1, 8, and 15 every 28 days) in the second-line setting. The primary end point was overall survival (OS).
Results:
Between August 2012 and October 2014, 131 patients, out of 140 planned, were randomly assigned. The study was terminated early on the recommendation of the independent data monitoring committee because of futility. Final analysis after the preplanned number of deaths (n = 110) occurred after a median follow-up of 18 months. One hundred fifteen deaths had occurred at the final data extract presented here. Median OS was 8.0 months for paclitaxel (80% CI, 6.9 to 9.7 months) and 4.7 months for pazopanib (80% CI, 4.2 to 6.4 months). The hazard ratio (HR) adjusted for baseline stratification factors was 1.28 (80% CI, 0.99 to 1.67; one-sided P = .89). Median progression-free survival was 4.1 months for paclitaxel (80% CI, 3.0 to 5.6 months) and 3.1 months for pazopanib (80% CI, 2.7 to 4.6 months; HR, 1.09; 80% CI, 0.85 to 1.40; one-sided P = .67). Discontinuations for toxicity occurred in 7.8% and 23.1% for paclitaxel and pazopanib, respectively.
Conclusion:
Pazopanib did not have greater efficacy than paclitaxel in the second-line treatment of urothelial cancers. There was a trend toward superior OS for paclitaxel
A multifrequency analysis of radio variability of blazars
We have carried out a multifrequency analysis of the radio variability of
blazars, exploiting the data obtained during the extensive monitoring programs
carried out at the University of Michigan Radio Astronomy Observatory (UMRAO,
at 4.8, 8, and 14.5 GHz) and at the Metsahovi Radio Observatory (22 and 37
GHz). Two different techniques detect, in the Metsahovi light curves, evidences
of periodicity at both frequencies for 5 sources (0224+671, 0945+408, 1226+023,
2200+420, and 2251+158). For the last three sources consistent periods are
found also at the three UMRAO frequencies and the Scargle (1982) method yields
an extremely low false-alarm probability. On the other hand, the 22 and 37 GHz
periodicities of 0224+671 and 0945+408 (which were less extensively monitored
at Metsahovi and for which we get a significant false-alarm probability) are
not confirmed by the UMRAO database, where some indications of ill-defined
periods about a factor of two longer are retrieved. We have also investigated
the variability index, the structure function, and the distribution of
intensity variations of the most extensively monitored sources. We find a
statistically significant difference in the distribution of the variability
index for BL Lac objects compared to flat-spectrum radio quasars (FSRQs), in
the sense that the former objects are more variable. For both populations the
variability index steadily increases with increasing frequency. The
distribution of intensity variations also broadens with increasing frequency,
and approaches a log-normal shape at the highest frequencies. We find that
variability enhances by 20-30% the high frequency counts of extragalactic
radio-sources at bright flux densities, such as those of the WMAP and Planck
surveys.Comment: A&A accepted. 12 pages, 16 figure
Massive Black Hole Binary Inspirals: Results from the LISA Parameter Estimation Taskforce
The LISA Parameter Estimation (LISAPE) Taskforce was formed in September 2007
to provide the LISA Project with vetted codes, source distribution models, and
results related to parameter estimation. The Taskforce's goal is to be able to
quickly calculate the impact of any mission design changes on LISA's science
capabilities, based on reasonable estimates of the distribution of
astrophysical sources in the universe. This paper describes our Taskforce's
work on massive black-hole binaries (MBHBs). Given present uncertainties in the
formation history of MBHBs, we adopt four different population models, based on
(i) whether the initial black-hole seeds are small or large, and (ii) whether
accretion is efficient or inefficient at spinning up the holes. We compare four
largely independent codes for calculating LISA's parameter-estimation
capabilities. All codes are based on the Fisher-matrix approximation, but in
the past they used somewhat different signal models, source parametrizations
and noise curves. We show that once these differences are removed, the four
codes give results in extremely close agreement with each other. Using a code
that includes both spin precession and higher harmonics in the
gravitational-wave signal, we carry out Monte Carlo simulations and determine
the number of events that can be detected and accurately localized in our four
population models.Comment: 14 pages, 2 figures, 5 tables, minor changes to match version to be
published in the proceedings of the 7th LISA Symposium. For more information
see the Taskforce's wiki at http://www.tapir.caltech.edu/dokuwiki/lisape:hom
Ethanol reversal of tolerance to the respiratory depressant effects of morphine
Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different effects of the drugs. Many opioid addicts regularly consume alcohol (ethanol), and post-mortem analyses of opioid overdose deaths have revealed an inverse correlation between blood morphine and ethanol levels. In the present study, we determined whether ethanol reduced tolerance to the respiratory depressant effects of opioids. Mice were treated with opioids (morphine, methadone, or buprenorphine) for up to 6 days. Respiration was measured in freely moving animals breathing 5% CO(2) in air in plethysmograph chambers. Antinociception (analgesia) was measured as the latency to remove the tail from a thermal stimulus. Opioid tolerance was assessed by measuring the response to a challenge dose of morphine (10 mg/kg i.p.). Tolerance developed to the respiratory depressant effect of morphine but at a slower rate than tolerance to its antinociceptive effect. A low dose of ethanol (0.3 mg/kg) alone did not depress respiration but in prolonged morphine-treated animals respiratory depression was observed when ethanol was co-administered with the morphine challenge. Ethanol did not alter the brain levels of morphine. In contrast, in methadone- or buprenorphine-treated animals no respiratory depression was observed when ethanol was co-administered along with the morphine challenge. As heroin is converted to morphine in man, selective reversal of morphine tolerance by ethanol may be a contributory factor in heroin overdose deaths
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