Corridor Talk: Conservation Humanities and the Future of Europe’s National Parks

Corridor Talk: Conservation Humanities and the Future of Europe’s National Parks is a DFG-AHRC funded project at the Rachel Carson Center for Environment and Society at LMU Munich (Germany), and the University of Leeds (UK). The project focuses on three European transboundary national park areas: the Pyrenees, the Bavarian Forest and Šumava, and the Wadden Sea Biosphere Reserve. It uses comparative literature, visual ethnography and environmental history methodologies to connect insights into human culture, values, history, and behaviour that are central to humanities and social sciences research to nature conservation science and practice. It aims to foster a conservation that is more culturally aware, more aware of human behaviour and values, and more aware of the ethical complexities of its work by applying the “corridor talk” metaphor in three ways: to address and support the material ecological corridors that link protected sites; to address and support the symbolic corridors that connect governance and cultural perspectives on protected sites; and to bring humanities research into discussions on nature conservation

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp. has been identified as a candidate target and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from T. brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. 8 compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development

Clinical characteristics, etiology, and initial management strategy of newly diagnosed periprosthetic joint infection: A multicenter, prospective observational cohort study of 783 patients

Background Periprosthetic joint infection (PJI) is a devastating complication of joint replacement surgery. Most observational studies of PJI are retrospective or single-center, and reported management approaches and outcomes vary widely. We hypothesized that there would be substantial heterogeneity in PJI management and that most PJIs would present as late acute infections occurring as a consequence of bloodstream infections. Methods The Prosthetic joint Infection in Australia and New Zealand, Observational (PIANO) study is a prospective study at 27 hospitals. From July 2014 through December 2017, we enrolled all adults with a newly diagnosed PJI of a large joint. We collected data on demographics, microbiology, and surgical and antibiotic management over the first 3 months postpresentation. Results We enrolled 783 patients (427 knee, 323 hip, 25 shoulder, 6 elbow, and 2 ankle). The mode of presentation was late acute (>30 days postimplantation and 30 days postimplantation with ≥30 days of symptoms; 148, 19%). Debridement, antibiotics, irrigation, and implant retention constituted the commonest initial management approach (565, 72%), but debridement was moderate or less in 142 (25%) and the polyethylene liner was not exchanged in 104 (23%). Conclusions In contrast to most studies, late acute infection was the most common mode of presentation, likely reflecting hematogenous seeding. Management was heterogeneous, reflecting the poor evidence base and the need for randomized controlled trials

Development of a novel once-through flow visualization technique for kinetic study of bulk and surface scaling

There is a considerable interest to investigate surface crystallization in order to have a full mechanistic understanding of how layers of sparingly soluble salts (scale) build on component surfaces. Despite much recent attention, a suitable methodology to improve on the understanding of the precipitation/deposition systems to enable the construction of an accurate surface deposition kinetic model is still needed. In this work, an experimental flow rig and associated methodology to study mineral scale deposition is developed. The once-through flow rig allows us to follow mineral scale precipitation and surface deposition in situ and in real time. The rig enables us to assess the effects of various parameters such as brine chemistry and scaling indices, temperature, flow rates, and scale inhibitor concentrations on scaling kinetics. Calcium carbonate (CaCO3) scaling at different values of the saturation ratio (SR) is evaluated using image analysis procedures that enable the assessment of surface coverage, nucleation, and growth of the particles with time. The result for turbidity values measured in the flow cell is zero for all the SR considered. The residence time from the mixing point to the sample is shorter than the induction time for bulk precipitation; therefore, there are no crystals in the bulk solution as the flow passes through the sample. The study shows that surface scaling is not always a result of pre-precipitated crystals in the bulk solution. The technique enables both precipitation and surface deposition of scale to be decoupled and for the surface deposition process to be studied in real time and assessed under constant condition

“I’m only a dog!” : the Rwandan genocide, dehumanisation and the graphic novel

Graphic novels written in response to the 1994 Rwandan genocide do not confine their depictions of traumatic violence to humans, but extend their coverage to show how the genocide impacted on animals and the environment. Through analysis of the presentation of people and their relationships with other species across a range of graphic narratives, this article shows how animal imagery was used to justify inhumane actions during the genocide, and argues that representations of animals remain central to the recuperation processes in a post-genocide context too. Whilst novels and films that respond to the genocide have been the focus of scholarly work (Dauge-Roth, 2010), the graphic novel has yet to receive substantial critical attention. This article therefore unlocks the archive of French-, Dutch- and English-language graphic narratives written in response to the genocide by providing the first in-depth, comparative analysis of their animal representations. It draws on recent methodological approaches derived from philosophy (Derrida, [2008] trans. 2009), postcolonial ecocriticism (Huggan and Tiffin, 2010) and postcolonial trauma theory (Craps, 2012) in order show how human-centred strategies for recovery, and associated symbolic orders that forcefully position the animal outside of human law, continue to engender unequal and potentially violent relationships between humans, and humans and other species. In this way, graphic narratives that gesture towards more equitable relationships between humans, animals and the environment can be seen to support the processes of recovery and reconciliation in post-genocide Rwanda

Decolonizing Science and Science Education in a Postcolonial Space (Trinidad, a Developing Caribbean Nation, Illustrates)

The article addresses how remnant or transformed colonialist structures continue to shape science and science education, and how that impact might be mitigated within a postcolonial environment in favor of the development of the particular community being addressed. Though cognizant of, and resistant to, the ongoing colonial impact globally and nationally (and any attempts at subjugation, imperialism, and marginalization), this article is not about anticolonial science. Indeed, it is realized that the postcolonial state of science and science education is not simply defined, and may exist as a mix of the scientific practices of the colonizer and the colonized. The discussion occurs through a generic postcolonial lens and is organized into two main sections. First, the discussion of the postcolonial lens is eased through a consideration of globalization which is held here as the new colonialism. The article then uses this lens to interrogate conceptions of science and science education, and to suggest that the mainstream, standard account of what science is seems to represent a globalized- or arguably a Western, modern, secular-conception of science. This standard account of science can act as a gatekeeper to the indigenous ways of being, knowing, and doing of postcolonial populations. The article goes on to suggest that as a postcolonial response, decolonizing science and science education might be possible through practices that are primarily contextually respectful and responsive. That is, localization is suggested as one possible antidote to the deleterious effects of globalization. Trinidad, a postcolonial developing Caribbean nation, is used as illustration

A bubble in the vein: suicide, community, and the rejection of neoliberalism in Hanya Yanagihara's A little life and Miriam Toews's All my puny sorrows

This chapter explores how Marlon James’ A Brief History of Seven Killings (2014) and Paulo Lins’ Cidade de Deus (City of God 1997) speak to the contemporary crisis in the neoliberal regime of accumulation, as well as to the initial struggle to impose neoliberalism in the global South. A Brief History registers the fallout from the turmoil in Jamaica in the 1970s, when Michael Manley’s efforts to pursue a path of democratic socialism were undermined by party-political gang warfare, economic crisis, and the impact of US imperialism. City of God, meanwhile, focuses primarily on the closed world of the titular favela, located on the western edge of Rio de Janeiro. Despite this limited compass, the “inexorable weight of contemporary history makes itself felt” in the novel’s representation of the desperate lives of its protagonists (Schwarz, Two Girls: And Other Essays. London: Verso, 2012: 227). Spanning the period from the 1960s to the early 1980s, the narrative is shadowed by the presence of the dictatorship in Brazil and by the unfolding logic of the world-economy. Through their formal logics and stylistic mannerisms, City of God and A Brief History rehearse the possibilities for both reactionary and progressive class realignments in the wake of hegemonic dissolution. The precise nature of these possibilities, however, is differentiated in the two novels by the specific social contexts and historical moments to which they respond