Context Mover's Distance & Barycenters: Optimal Transport of Contexts for Building Representations

We present a framework for building unsupervised representations of entities and their compositions, where each entity is viewed as a probability distribution rather than a vector embedding. In particular, this distribution is supported over the contexts which co-occur with the entity and are embedded in a suitable low-dimensional space. This enables us to consider representation learning from the perspective of Optimal Transport and take advantage of its tools such as Wasserstein distance and barycenters. We elaborate how the method can be applied for obtaining unsupervised representations of text and illustrate the performance (quantitatively as well as qualitatively) on tasks such as measuring sentence similarity, word entailment and similarity, where we empirically observe significant gains (e.g., 4.1% relative improvement over Sent2vec, GenSen). The key benefits of the proposed approach include: (a) capturing uncertainty and polysemy via modeling the entities as distributions, (b) utilizing the underlying geometry of the particular task (with the ground cost), (c) simultaneously providing interpretability with the notion of optimal transport between contexts and (d) easy applicability on top of existing point embedding methods. The code, as well as prebuilt histograms, are available under https://github.com/context-mover/.Comment: AISTATS 2020. Also, accepted previously at ICLR 2019 DeepGenStruct Worksho

Long-term subcutaneous morphine administration after surgery in newborns

Aim: To analyze the management of newborns after major surgery receiving morphine subcutaneously and to identify possible side effects. Methods: Morphine was administered via a subcutaneous catheter (Insuflon®) in 20 newborns after major surgery. Side effects like hypotension, pain during morphine administration and local infection were noted. Morphine dose was adjusted according to the hospital guidelines with the Neonatal Infant Pain Score (NIPS) and the Finnegan withdrawal score. Results: Surgery was performed at the median age of 38 5/7weeks (range: 32 1/7-49 5/7weeks). Before starting subcutaneous morphine administration, patients received intravenous morphine for a median of two weeks (range sixdays to sevenweeks). All patients showed good pain relief with no severe side effects. Three patients reacted with crying to the first dose of subcutaneous morphine. No other side effects occurred. Conclusion: Subcutaneous application of morphine with the Insuflon® catheter is an alternative to intravenous treatment of postoperative pain in neonates. In this small group pain relief was good and side effects were harmles

Temporary Kirschner Wire Ankle Transfixation and Delayed ORIF: A Staged Operative Treatment for Closed Ankle Fractures with Tibiotalar Dislocations and Soft-Tissue Damage

Abstract : Background and Purpose: : Immediate ORIF (open reduction and internal fixation) is the treatment of choice for displaced ankle fractures. However, definitive treatment may have to be delayed due to compromised soft tissues. The value of temporary Kirschner wire ankle transfixation with staged ORIF for closed displaced ankle fractures with tibiotalar dislocations was determined. Patients and Methods: : In this retrospective case series (1997-2001), 92 patients (mean age 54 years, range 20-86 years) who underwent a staged procedure for isolated and closed displaced ankle fractures with tibiotalar dislocations were studied. Patients were primarily treated by means of immediate closed reduction. For stable fractures and adequate soft tissues a split plaster cast was applied (n = 50). K-wire transfixation was performed for unstable fracture-dislocations and/or critical soft tissues (n = 42). All patients underwent delayed ORIF after recovery of the soft tissues. Results: : In the K-wire group (KWG), local complication rate was 7%. Mean operating time was 30 min (5-65 min). In the plaster cast group (PCG), local complication rate was 10% (p = 0.72, not significant). Three redislocated ankles (6%) had to be transfixed secondarily. A higher grade of soft-tissue injuries in the KWG (p < 0.05) resulted in a longer time interval between primary treatment and staged ORIF (7 vs. 5 days; p < 0.05) and a longer hospital stay (19 vs. 17 days; p < 0.05) for the KWG. Conclusion: : Temporary K-wire ankle transfixation is an effective method for initial treatment of closed displaced ankle fractures with tibiotalar dislocation, if ORIF has to be delayed and immobilization in a split plaster cast is not suitable. Retention is reliable with a low complication rat

Arbeit und Krankheit : Berufliche Wiedereingliederung von Personen mit länger andauernder Arbeitsunfähigkeit - Eine Untersuchung zur Rolle des Rechts und des sozialen Umfelds

Weshalb gelingt es einigen Erwerbspersonen besser als andern, sich nach einer länger andauernden Arbeitsunfähigkeitsphase wieder in den Erwerbsprozess zu integrieren? In einem mehrjährigen Forschungsprojekt (2008-2012) wurde das komplexe Wechselspiel zwischen Individuen, sozialen, rechtlichen und gesellschaftlichen Kontextbedingungen und den beteiligten Betrieben und Institutionen analysiert. Vorschläge für Massnahmen zur Verhinderung der Desintegration runden die Studie ab. Das Projekt wurde vom schweizerischen Nationalfonds (SNF) unterstützt und gemeinsam vom Büro für arbeits- und sozialpolitische Studien BASS und der ZHAW – Zentrum für Sozialrecht durchgeführt

Investigation of the High-Temperature Redox Chemistry of Sr\u3csub\u3e2\u3c/sub\u3eFe\u3csub\u3e1.5\u3c/sub\u3eMo\u3csub\u3e0.5\u3c/sub\u3eO\u3csub\u3e6-δ\u3c/sub\u3e\u3ci\u3e via In Situ\u3c/i\u3e Neutron Diffraction

Crystallographic structural changes were investigated for Sr2Fe1.5Mo0.5O6−δ, an electrode material for symmetric solid oxide fuel cells. The samples of this material were heated and cooled in wet hydrogen and wet oxygen atmospheres, to simulate the reducing and oxidizing conditions experienced under actual fuel cell operating conditions, and their structures and oxygen contents were determined using in situ powder neutron diffraction. The existence of a reversible tetragonal to cubic phase transition was established to occur between room temperature and 400 °C, both on heating and cooling in either oxygen or hydrogen. The oxygen content reaches a low value of 5.50(2) at 850 °C in wet hydrogen. Excellent correlations are observed between the oxygen content of the structure and the conductivities reported in the literature

Sulphur tolerant diesel oxidation catalysts by noble metal alloying

A series of Mn-alloyed Pt supported catalysts were investigated for the NO oxidation reaction applied in diesel oxidation catalysts under sulphur-containing conditions. The observed NO oxidation conversion correlated to the Pt amount in the catalyst under sulphur-free conditions. In the presence of SO2 in the feed, the Pt/Al2O3 catalyst heavily deactivated resulting in the lowest performance compared to Mn-alloyed Pt catalysts. Already small amounts of Mn improved the SO2-resistance significantly. Whilst pure Pt/Al2O3 catalyst deactivates fully within the first 30 min under NO oxidation conditions including 300 ppm SO2, an alloy with a Mn to Pt ratio of 1:1 performed with a remarkable high catalytic stability for the NO oxidation over at least 70 h under continuous testing conditions

A risk model for prediction of diagnosis of cancer after ischemic stroke

It remains controversial which characteristics may predict occult cancer in stroke patients. Characteristics of patients with ischemic stroke registered in the Zurich Swiss Stroke Registry (2014 to 2016) were tested for associations with cancer diagnosis after stroke with consideration of death as competing risk for cancer diagnosis. Among 1157 patients, 34 (3%) and 55 patients (5%) were diagnosed with cancer within 1 and 3 years after stroke. Levels of white blood cells (WBC) > 9,600/µl (subdistribution hazard ratio (SHR) 3.68, p = 0.014), platelets > 400,000/µl (SHR 7.71, p = 0.001), and d-dimers ≥ 3 mg/l (SHR 3.67, p = 0.007) were independently associated with cancer diagnosis within 1 year after stroke. Occurrence of ischemic lesions in ≥ 2 vascular territories not attributed to cardioembolic etiology was associated with cancer diagnosed within 1 year after stroke in univariable analysis (SHR 3.69, p = 0.001). The area under the curve of a score from these parameters (score sum 0-4) was 0.73. A score of ≥ 2 had a sensitivity of 43% and specificity of 92% for prediction of cancer diagnosis within 1 year after stroke. We suggest further validation of a score of WBC, platelets, d-dimers and multiple ischemic lesions without cardioembolic stroke etiology for prediction of cancer diagnosis after stroke

Ulnar nerve integrity predicts 1-year outcome in cervical spinal cord injury

Background: Accurate predictors of neurological recovery after cervical spinal cord injury are needed. Particularly, to tailor adequate rehabilitation plans. However, objective and quantifiable predictors are sparse. Methods: Within the prospective European Multicenter Study about Spinal Cord Injury (EMSCI) registry, cervical spinal cord injury patients are monitored at fixed follow up visits (2, 4, 12, 24, and 48 weeks after injury) clinically and with ulnar nerve electroneurography. Associations of ulnar nerve compound muscle action potential amplitudes (CMAP) with American Spinal Cord Injury Association (ASIA) impairment scale (AIS) grades over time were analyzed using linear mixed modeling. Applying logistic regression, the prognostic value of within 4-week ulnar nerve CMAP for 1-year AIS was analyzed. To account for missing data, (1) last observation carried forward and (2) multiple imputation methods were applied. For model derivation, our centers’ cohort (EMSCI-HD) was analyzed. For model validation the cohort of other centers (EMSCI-nonHD) was used. Results: In the EMSCI-HD cohort, the median age (interquartile range (IQR)) was 52 (34–67) years. 58% were male. The initial AIS distribution was: A = 31%, B = 17%, C = 30%, and D = 22%). In the EMSCI-nonHD cohort, the median age was 49 (32–65) years. Compared to the EMSCI-HD cohort more patients were male (79%, p = 0.0034). The AIS distribution was: A = 33%, B = 13%, C = 21%, and D = 33%). In complete-case mixed model analyses (EMSCI-HD: n = 114; EMSCI-nonHD: n = 508) higher ulnar nerve CMAP were associated with better AIS grades over the entire follow up period. In complete-case logistic regression (EMSCI-HD: n = 90; EMSCI-nonHD: n = 444) higher ulnar nerve CMAP was an independent predictor of better AIS grades. The odds ratio for within 4-week ulnar nerve CMAP to predict 1-year AIS grade D versus A-C in the EMSCI-HD cohort was 1.24 per millivolt (confidence interval 1.07–1.44). The model was validated in an independent cervical spinal cord injury (EMSCI-nonHD) cohort (odds ratio 1.09, confidence interval 1.03–1.17). Conclusions: In cervical spinal cord injury, the consideration of early ulnar nerve CMAP improves prognostic accuracy, which is of particular importance in patients with clinical grading uncertainties