Stereo TV enhancement study Final technical report

Human depth perception of television displays in stereo, and nonstereo presentation

Hard X-ray imaging facility for space shuttle: A scientific and conceptual engineering study

A shuttle-accommodated instrument for imaging hard X-rays in the study of nonthermal particles and high temperature particles in various solar and cosmic phenomena was defined and its feasibility demonstrated. The imaging system configuration is described as well as the electronics, aspect systems, mechanical and thermal properties and the ground support equipment

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

When it is difficult to develop selective ligands within a family of related G-protein-coupled receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (RASSLs) are useful alternatives for probing receptor function. In the present work, we explored whether a RASSL of the free fatty acid receptor 2 (FFA2) could be developed on the basis of pharmacological variation between species orthologs. For this, bovine FFA2 was characterized, revealing distinct ligand selectivity compared with human FFA2. Homology modeling and mutational analysis demonstrated a single mutation in human FFA2 of C4.57G resulted in a human FFA2 receptor with ligand selectivity similar to the bovine receptor. This was exploited to generate human FFA2-RASSL by the addition of a second mutation at a known orthosteric ligand interaction site, H6.55Q. The resulting FFA2-RASSL displayed a >100-fold loss of activity to endogenous ligands, while responding to the distinct ligand sorbic acid with pEC(50) values for inhibition of cAMP, 5.83 ± 0.11; Ca(2+) mobilization, 4.63 ± 0.05; ERK phosphorylation, 5.61 ± 0.06; and dynamic mass redistribution, 5.35 ± 0.06. This FFA2-RASSL will be useful in future studies on this receptor and demonstrates that exploitation of pharmacological variation between species orthologs is a powerful method to generate novel chemically engineered GPCRs

An analysis of strong-motion accelerometer data from the San Francisco earthquake of March 22, 1957

The San Francisco earthquake of March 22, 1957, was recorded simultaneously by accelerometers at five United States Coast and Geodetic Survey stations in the San Francisco area. Response spectrum curves were computed from the acceleration-time records, and from these response spectrum curves the spectrum intensities have been determined. From these spectrum intensities certain conclusions are drawn as to: (1) the effects of local geology on the recorded ground motions; (2) the calculation of total energy released by the earthquake from strong-motion accelerometer records; (3) possible influence of structural dynamic behavior on the accelerations recorded in building basements, and the relationship between basement accelerations and ground accelerations; and (4) the applicability of a simplified type of strong-motion earthquake instrument for investigations of local distribution effects. A general comparison is made between the present earthquake and typical Pacific Coast earthquakes

The Port Hueneme earthquake of March 18, 1957

The Port Hueneme earthquake of March 18, 1957, was the first recorded strong-motion earthquake for which the ground motion consisted essentially of a single pulse. Since all the energy of the earthquake was concentrated in one pulse, the ground accelerations and the response spectrum values were considerably larger than for more typical Pacific Coast earthquakes of equivalent magnitude. These abnormally high values are reflected in damage reports, which indicated an unusual amount of damage for a shock of magnitude 4.7

Microsecond resolution of quasiparticle tunneling in the single-Cooper-pair-transistor

We present radio-frequency measurements on a single-Cooper-pair-transistor in which individual quasiparticle poisoning events were observed with microsecond temporal resolution. Thermal activation of the quasiparticle dynamics is investigated, and consequently, we are able to determine energetics of the poisoning and un-poisoning processes. In particular, we are able to assign an effective quasiparticle temperature to parameterize the poisoning rate.Comment: 4 pages, 4 fig

A de Finetti Representation Theorem for Quantum Process Tomography

In quantum process tomography, it is possible to express the experimenter's prior information as a sequence of quantum operations, i.e., trace-preserving completely positive maps. In analogy to de Finetti's concept of exchangeability for probability distributions, we give a definition of exchangeability for sequences of quantum operations. We then state and prove a representation theorem for such exchangeable sequences. The theorem leads to a simple characterization of admissible priors for quantum process tomography and solves to a Bayesian's satisfaction the problem of an unknown quantum operation.Comment: 10 page

Report from solar physics

A discussion of the nature of solar physics is followed by a brief review of recent advances in the field. These advances include: the first direct experimental confirmation of the central role played by thermonuclear processes in stars; the discovery that the 5-minute oscillations of the Sun are a global seismic phenomenon that can be used as a probe of the structure and dynamical behavior of the solar interior; the discovery that the solar magnetic field is subdivided into individual flux tubes with field strength exceeding 1000 gauss. Also covered was a science strategy for pure solar physics. Brief discussions are given of solar-terrestrial physics, solar/stellar relationships, and suggested space missions