Enhanced recovery after surgery-ERAS-principles, practice and feasibility in the elderly.

This is a short overview of the principles of a novel development in surgery called enhanced recovery after surgery (ERAS) programs. This is an evidence-based approach to perioperative care that has shown to reduce complications and recovery time by 30-50%. The main mechanism is reduction of the stress reactions to the operation. These principles have been shown to be particularly well suited for the compromised patient and hence very good for the elderly people who often have co-morbidities and run a higher risk of complications

Protease inhibitor 15, a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat

The inbred Brown Norway (BN) rat develops spontaneous ruptures of the internal elastic lamina (RIEL) of the abdominal aorta (AA) and iliac arteries. Prior studies with crosses of the BN/Orl RJ (susceptible) and LOU/M (resistant) showed the presence of a significant QTL on chromosome 5 and the production of congenic rats proved the involvement of this locus. In this study, we further dissected the above-mentioned QTL by creating a new panel of LOU.BN(chr5) congenic and sub-congenic lines and reduced the locus to 5.2 Mb. Then 1002 HS rats were studied, whose phenotyping revealed a low prevalence and high variability for RIEL. High resolution mapping in the HS panel detected the major locus on chromosome 5 (log P>35) and refined it to 1.4Mb. Subsequently, RNA-seq analysis on AA of BN, congenics and LOU revealed expression differences for only protease inhibitor15 (Pi15) gene and a putative long intergenic noncoding RNA (lincRNA) within the linkage region. The high abundance of lincRNA with respect to reduced Pi15 expression, in conjunction with exertion of longitudinal strain, may be related to RIEL, indicating the potential importance of proteases in biological processes related to defective aortic IEL structure. Similar mechanisms may be involved in aneurysm initiation in the human AA

The Aladin2 experiment: sensitivity study

Aladin2 is an experiment devoted to the first measurement of variations of Casimir energy in a rigid body. The main short-term scientific motivation relies on the possibility of the first demonstration of a phase transition influenced by vacuum fluctuations while, in the long term and in the mainframe of the cosmological constant problem, it can be regarded as the first step towards a measurement of the weight of vacuum energy. In this paper, after a presentation of the guiding principle of the measurement, the experimental apparatus and sensitivity studies on final cavities will be presented

A Survey Investigating the Combination and Number of IMUs on the Human Body Used for Detecting Activities and Human Tracking

In the present paper we give a classification of the position and the number of inertial measurement units (IMU) used to detect human activities and position tracking based on literature review. It presents a separate view of IMU position and IMU numbers placed on the human body. In total 60 relevant studies were found which focused on human activity recognition (HAR) and tracking with dead-reckoning. The focus lies on the number, the sample frequencies and the positioning of IMUs. To the best of our knowledge, this is the first work which looks particularly at the number and position of IMUs. The result shows that a comparison between the different studies fails, because the description of the positions is not precise enough and not uniform

Variation in nucleotide homology obtained by amplification, cloning and sequencing of complete S1 gene from field samples of avian infectious bronchitis virus.

Projeto/Plano de Ação: 02.09.01.030

Numerical Analysis of an Overtopping Wave Energy Converter Subjected to the Incidence of Irregular and Regular Waves from Realistic Sea States

The present study aims to evaluate the difference in the fluid-dynamic behavior of an overtopping wave energy converter under the incidence of irregular waves based on a realistic sea state when compared to the incidence of regular waves, representative of this sea state. Thus, the sea data of three regions from the Rio Grande do Sul coast, Brazil, were considered. Fluent software was employed for the computational modeling, which is based on the finite volume method (FVM). The numerical generation of waves occurred through the imposition of the velocity boundary conditions using transient discrete values through the WaveMIMO methodology. The volume of fluid (VOF) multiphase model was applied to treat the water–air interaction. The results for the water amount accumulated in the device reservoir showed that the fluid-dynamic behavior of the overtopping converter has significant differences when comparing the two proposed approaches. Differences up to 240% were found for the water mass accumulated in the overtopping device reservoir, showing evidence that the results can be overestimated when the overtopping device is analyzed under the incidence of the representative regular waves. Furthermore, for all studied cases, it was possible to approximate the water volume accumulated over time in the overtopping reservoir through a first-degree polynomial function

Numerical Relativity Using a Generalized Harmonic Decomposition

A new numerical scheme to solve the Einstein field equations based upon the generalized harmonic decomposition of the Ricci tensor is introduced. The source functions driving the wave equations that define generalized harmonic coordinates are treated as independent functions, and encode the coordinate freedom of solutions. Techniques are discussed to impose particular gauge conditions through a specification of the source functions. A 3D, free evolution, finite difference code implementing this system of equations with a scalar field matter source is described. The second-order-in-space-and-time partial differential equations are discretized directly without the use first order auxiliary terms, limiting the number of independent functions to fifteen--ten metric quantities, four source functions and the scalar field. This also limits the number of constraint equations, which can only be enforced to within truncation error in a numerical free evolution, to four. The coordinate system is compactified to spatial infinity in order to impose physically motivated, constraint-preserving outer boundary conditions. A variant of the Cartoon method for efficiently simulating axisymmetric spacetimes with a Cartesian code is described that does not use interpolation, and is easier to incorporate into existing adaptive mesh refinement packages. Preliminary test simulations of vacuum black hole evolution and black hole formation via scalar field collapse are described, suggesting that this method may be useful for studying many spacetimes of interest.Comment: 18 pages, 6 figures; updated to coincide with journal version, which includes some expanded discussions and a new appendix with a stability analysis of a simplified problem using the same discretization scheme described in the pape

Genetical genomics: spotlight on QTL hotspots

No abstract available

Feasibility and safety of PIPAC combined with additional surgical procedures: PLUS study.

PIPAC (Pressurized IntraPeritoneal Aerosol Chemotherapy) is a minimally invasive approach relying on physical principles for improving intraperitoneal drug delivery, including optimizing the homogeneity of drug distribution through an aerosol. Feasibility and safety of the new approach are now consolidated and data on its effectiveness are continuously increasing. Although any surgical procedure associated with PIPAC had always been discouraged due to the high risk of complications, surgical practice is constantly changing: with growing expertise, more and more surgical teams associate PIPAC with surgery. PLUS study is part of the retrospective international cohort studies including 10 centers around the world (India, Italy, France, Germany, Belgium, Russia, Saudi Arabia, Switzerland) and 96 cases of combined approaches evaluated through a propensity score analysis. the procedures most frequently associated with PIPAC were not only adhesiolysis, omentectomy, adnexectomy, umbilical/inguinal hernia repairs, but also more demanding procedures such as intestinal resections, gastrectomy, splenectomy, bowel repair/stoma creation. Although the evidence is currently limited, PLUS study demonstrated that PIPAC associated with additional surgical procedures is linked to an increase of surgical time (p < 0.001), length of stay (p < 0.001) and medical complication rate (p < 0.001); the most frequently reported medical complications were mild or moderate in severity, such as abdominal pain, nausea, ileus and hyperthermia. No difference in terms of surgical complications was registered; neither reoperation or postoperative deaths were reported. these results suggest that PIPAC can be safely combined in expert centers with additional surgeries. Widespread change of practice should be discouraged before the results of ongoing prospective studies are available