263 research outputs found
Erving Goffman\u27s Presentation of Self as ASA President
Dr. Joan Humber, professor emeritus of sociology at the Oho State University, wrote this memoir at the request of Dmitri Shalin and gave her permission to post it in the Erving Goffman Archives
Readers\u27 Speakout
Dear Florence Howe:
Devoting an entire issue to the First Annual Convention of the National Women\u27s Studies Association was enormously helpful to those of us who could not attend. The reports on the Convention indicated that it was simply first-rate. Nothing in the issue, however, helped me to understand why some delegates trashed the U.S. Agency for International Development (AID) and scapegoated its representative, Kathleen Staudt. I had hoped to learn why because a number of colleagues returned from the Convention with the story that everyone agreed that AID had no business being there. But no one could explain why. All I have heard are vague stories, most of them quite silly
Warped Electroweak Breaking Without Custodial Symmetry
We propose an alternative to the introduction of an extra gauge (custodial)
symmetry to suppress the contribution of KK modes to the T parameter in warped
theories of electroweak breaking. The mechanism is based on a general class of
warped 5D metrics and a Higgs propagating in the bulk. The metrics are nearly
AdS in the UV region but depart from AdS in the IR region, towards where KK
fluctuations are mainly localized, and have a singularity outside the slice
between the UV and IR branes. This gravitational background is generated by a
bulk stabilizing scalar field which triggers a natural solution to the
hierarchy problem. Depending on the model parameters, gauge-boson KK modes can
be consistent with present bounds on EWPT for m > 1 TeV at 95% CL. The model
contains a light Higgs mode which unitarizes the four-dimensional theory. The
reduction in the precision observables can be traced back to a large wave
function renormalization for this mode.Comment: 15 pages, 3 figure
The K2 Mission: Characterization and Early results
The K2 mission will make use of the Kepler spacecraft and its assets to
expand upon Kepler's groundbreaking discoveries in the fields of exoplanets and
astrophysics through new and exciting observations. K2 will use an innovative
way of operating the spacecraft to observe target fields along the ecliptic for
the next 2-3 years. Early science commissioning observations have shown an
estimated photometric precision near 400 ppm in a single 30 minute observation,
and a 6-hour photometric precision of 80 ppm (both at V=12). The K2 mission
offers long-term, simultaneous optical observation of thousands of objects at a
precision far better than is achievable from ground-based telescopes. Ecliptic
fields will be observed for approximately 75-days enabling a unique exoplanet
survey which fills the gaps in duration and sensitivity between the Kepler and
TESS missions, and offers pre-launch exoplanet target identification for JWST
transit spectroscopy. Astrophysics observations with K2 will include studies of
young open clusters, bright stars, galaxies, supernovae, and asteroseismology.Comment: 25 pages, 11 figures, Accepted to PAS
Suppressing Electroweak Precision Observables in 5D Warped Models
We elaborate on a recently proposed mechanism to suppress large contributions
to the electroweak precision observables in five dimensional (5D) warped
models, without the need for an extended 5D gauge sector. The main ingredient
is a modification of the AdS metric in the vicinity of the infrared (IR) brane
corresponding to a strong deviation from conformality in the IR of the 4D
holographic dual. We compute the general low energy effective theory of the 5D
warped Standard Model, emphasizing additional IR contributions to the wave
function renormalization of the light Higgs mode. We also derive expressions
for the S and T parameters as a function of a generic 5D metric and zero-mode
wave functions. We give an approximate formula for the mass of the radion that
works even for strong deviation from the AdS background. We proceed to work out
the details of an explicit model and derive bounds for the first KK masses of
the various bulk fields. The radion is the lightest new particle although its
mass is already at about 1/3 of the mass of the lightest resonances, the KK
states of the gauge bosons. We examine carefully various issues that can arise
for extreme choices of parameters such as the possible reintroduction of the
hierarchy problem, the onset of nonperturbative physics due to strong IR
curvature or the creation of new hierarchies near the Planck scale. We conclude
that a KK scale of 1 TeV is compatible with all these constraints.Comment: 44 pages, 11 figures, references adde
Flavor Phenomenology in General 5D Warped Spaces
We have considered a general 5D warped model with SM fields propagating in
the bulk and computed explicit expressions for oblique and non-oblique
electroweak observables as well as for flavor and CP violating effective
four-fermion operators. We have compared the resulting lower bounds on the
Kaluza-Klein (KK) scale in the RS model and a recently proposed model with a
metric modified towards the IR brane, which is consistent with oblique
parameters without the need for a custodial symmetry. We have randomly
generated 40,000 sets of O(1) 5D Yukawa couplings and made a fit of the quark
masses and CKM matrix elements in both models. This method allows to identify
the percentage of points consistent with a given KK mass, which in turn
provides us with a measure for the required fine-tuning. Comparison with
current experimental data on Rb, FCNC and CP violating operators exhibits an
improved behavior of our model with respect to the RS model. In particular,
allowing 10% fine-tuning the combined results point towards upper bounds on the
KK gauge boson masses around 3.3 TeV in our model as compared with 13 TeV in
the RS model. One reason for this improvement is that fermions in our model are
shifted, with respect to fermions in the RS model, towards the UV brane thus
decreasing the strength of the modifications of electroweak observables.Comment: 28 pages, 7 figures, 4 table
Pharmacologic activation of LXR alters the expression profile of tumor-associated macrophages and the abundance of regulatory T cells in the tumor microenvironment
Liver X receptors (LXR) are transcription factors from the nuclear receptor family that are activated by oxysterols and synthetic high-affinity agonists. In this study, we assessed the antitumor effects of synthetic LXR agonist TO901317 in a murine model of syngeneic Lewis Lung carcinoma. Treatment with TO901317 inhibited tumor growth in wild-type, but not in LXR-deficient mice, indicating that the antitumor effects of the agonist depends on functional LXR activity in host cells. Pharmacologic activation of the LXR pathway reduced the intratumoral abundance of regulatory T cells (Treg) and the expression of the Treg-attracting chemokine Ccl17 by MHCIIhigh tumor-associated macrophages (TAM). Moreover, gene expression profiling indicated a broad negative impact of the LXR agonist on other mechanisms used by TAM for the maintenance of an immunosuppressive environment. In studies exploring the macrophage response to GM-CSF or IL4, activated LXR repressed IRF4 expression, resulting in subsequent downregulation of IRF4-dependent genes including Ccl17. Taken together, this work reveals the combined actions of the LXR pathway in the control of TAM responses that contribute to the antitumoral effects of pharmacologic LXR activation. Moreover, these data provide new insights for the development of novel therapeutic options for the treatment of cancer.This work was supported by the following grants: Spanish Ministry of Economy and Competitivity (MINECO) grants SAF2017-89510-R and SAF2014-57856-P [to A.F. Valledor and C. Caelles; SAF2014-56819-R to A. Castrillo; SAF2017-90604-REDT and SAF2015-71878-REDT to the NuRCaMeIn network (to A.F. Valledor, C. Caelles, and A. Castrillo); Spanish Ministry of Science and Innovation (MICINN) grants SAF2011-23402 and SAF2010-14989 (to A.F. Valledor); Fundacio La Marato de TV3 grant 080930 (to A.F. Valledor); grants DFG HU 1824/5-1, 1824/7-1, and 1824/9-1 (to M. Huber); the European Cooperation in Science and Technology (COST) Action BM1404 Mye-EUNITER (http://www.mye-euniter. eu/; to A.F. Valledor, J.A. Van Ginderachter); and Instituto de Salud Carlos III and FEDER “Una manera de hacer Europa” grant FIS 16/00139 (to J.C. Escola-Gil). CIBERDEM is an Instituto de Salud Carlos III project. J.M. C received a fellowship from the University of Barcelona (APIF) and J. Font-Díaz received a fellowship
from the Spanish Ministry of Science, Innovation and Universities (FPI, PRE2018-085579)
Pharmacological activation of LXR alters the expression profile of tumor-associated macrophages and the abundance of regulatory T cells in the tumor microenvironment
Liver X receptors (LXR) are transcription factors from the nuclear receptor family that are activated by oxysterols and synthetic high-affinity agonists. In this study, we assessed the anti-tumor effects of synthetic LXR agonist TO901317 in a murine model of syngeneic Lewis Lung carcinoma. Treatment with TO901317 inhibited tumor growth in wild-type but not in LXR-deficient mice, indicating that the anti-tumor effects of the agonist depends on functional LXR activity in host cells. Pharmacological activation of the LXR pathway reduced the intratumoral abundance of regulatory T cells (Treg) and the expression of the Treg-attracting chemokine Ccl17 by MHCIIhigh tumor-associated macrophages (TAM). Moreover, gene expression profiling indicated a broad negative impact of the LXR agonist on other mechanisms used by TAM for the maintenance of an immunosuppressive environment. In studies exploring the macrophage response to GM-CSF or IL-4, activated LXR repressed IRF4 expression, resulting in subsequent downregulation of IRF4-dependent genes including Ccl17. Taken together, this work reveals the combined actions of the LXR pathway in the control of TAM responses that contribute to the anti-tumoral effects of pharmacological LXR activation. Moreover, these data provide new insights for the development of novel therapeutic options for the treatment of cancer
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy
Càncer; Macròfags associats al tumor: LIF; CD8Cáncer; Macrófagos asociados al tumor; CD8Cancer; Tumor-associated macrophages; CD8Cancer response to immunotherapy depends on the infiltration of CD8+ T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in the regulation of CD8+ T cell tumor infiltration, while promoting the presence of protumoral tumor-associated macrophages. We observe that the blockade of LIF in tumors expressing high levels of LIF decreases CD206, CD163 and CCL2 and induces CXCL9 expression in tumor-associated macrophages. The blockade of LIF releases the epigenetic silencing of CXCL9 triggering CD8+ T cell tumor infiltration. The combination of LIF neutralizing antibodies with the inhibition of the PD1 immune checkpoint promotes tumor regression, immunological memory and an increase in overall survival
Bridging Alone: Religious Conservatism, Marital Homogamy, and Voluntary Association Membership
This study characterizes social insularity of religiously conservative American married couples by examining patterns of voluntary associationmembership. Constructing a dataset of 3938 marital dyads from the second wave of the National Survey of Families and Households, the author investigates whether conservative religious homogamy encourages membership in religious voluntary groups and discourages membership in secular voluntary groups. Results indicate that couples’ shared affiliation with conservative denominations, paired with beliefs in biblical authority and inerrancy, increases the likelihood of religious group membership for husbands and wives and reduces the likelihood of secular group membership for wives, but not for husbands. The social insularity of conservative religious groups appears to be reinforced by homogamy—particularly by wives who share faith with husbands
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