Risk of cardiovascular events from current, recent, and cumulative exposure to abacavir among persons living with HIV who were receiving antiretroviral therapy in the United States: a cohort study.

BackgroundThere is ongoing controversy regarding abacavir use in the treatment of HIV infection and the risk of subsequent development of cardiovascular disease. It is unclear how the risk varies as exposure accumulates.MethodsUsing an administrative health-plan dataset, risk of cardiovascular disease events (CVDe), defined as the first episode of an acute myocardial infarction or a coronary intervention procedure, associated with abacavir exposure was assessed among HIV-infected individuals receiving antiretroviral therapy across the U.S. from October 2009 through December 2014. The data were longitudinal, and analyzed using marginal structural models.ResultsOver 114,470 person-years (n = 72,733) of ART exposure, 714 CVDe occurred at an incidence rate (IR) (95% CI) of 6·23 (5·80, 6·71)/1000 person-years. Individuals exposed to abacavir had a higher IR of CVDe of 9·74 (8·24, 11·52)/1000 person-years as compared to 5·75 (5·30, 6·24)/1000 person-years for those exposed to other antiretroviral agents. The hazard (HR; 95% CI) of CVDe was increased for current (1·43; 1·18, 1·73), recent (1·41; 1·16, 1·70), and cumulative [(1·18; 1·06, 1·31) per year] exposure to abacavir. The risk for cumulative exposure followed a bell-shaped dose-response curve peaking at 24-months of exposure. Risk was similarly elevated among participants free of pre-existing heart disease or history of illicit substance use at baseline.ConclusionCurrent, recent, and cumulative use of abacavir was associated with an increased risk of CVDe. The findings were consistent irrespective of underlying cardiovascular risk factors

Many-body approach to the nonlinear interaction of charged particles with an interacting free electron gas

We report various many-body theoretical approaches to the nonlinear decay rate and energy loss of charged particles moving in an interacting free electron gas. These include perturbative formulations of the scattering matrix, the self-energy, and the induced electron density. Explicit expressions for these quantities are obtained, with inclusion of exchange and correlation effects.Comment: 11 pages, 5 figures. To appear in Journal of Physics

Fractional Aharonov-Bohm effect in mesoscopic rings

We study the effects of correlations on a one dimensional ring threaded by a uniform magnetic flux. In order to describe the interaction between particles, we work in the framework of the U $\infty$ Hubbard and $t$-$J$ models. We focus on the dilute limit. Our results suggest the posibility that the persistent current has an anomalous periodicity $\phi_{0}/p$, where $p$ is an integer in the range $2\leq p\leq N_{e}$ ($N_{e}$ is the number of particles in the ring and $\phi_{0}$ is the flux quantum). We found that this result depends neither on disorder nor on the detailed form of the interaction, while remains the on site infinite repulsion.Comment: 14 pages (Revtex), 5 postscript figures. Send e-mail to: [email protected]

Innovative Airport Visual Aids to Enhance Situational Awareness and Flight Training for General Aviation

Runway incursionsare a threat to runway safety andhave been increasing in recent years. Incursions are categorized into three categories, pilot deviations (PD), operational incidents (OI), and vehicle pedestrian deviations (VPD). At general aviation airports, PDs are the most prevalent runway incursion type. Inadequate situational awareness is one of the human factors associated with PDs. Student pilots,pilots flying to an unfamiliar airport, ground operations personnel, and emergencyplanning and emergency responders can benefit from the use of visual aids that extend beyond an airport diagram or static Google Earth imagery. More robust visual aids can potentially increase situational awareness and reduce the risk of a runway incursion, and increase airfield familiarity through 360-degree photographs of the airfieldfacilities, including markings, signage, and intersecting taxiways/runways. This educational and informationaltool has the ability to increase familiarity of airfield characteristicsand increase safety

Effective band-structure in the insulating phase versus strong dynamical correlations in metallic VO2

Using a general analytical continuation scheme for cluster dynamical mean field calculations, we analyze real-frequency self-energies, momentum-resolved spectral functions, and one-particle excitations of the metallic and insulating phases of VO2. While for the former dynamical correlations and lifetime effects prevent a description in terms of quasi-particles, the excitations of the latter allow for an effective band-structure. We construct an orbital-dependent, but static one-particle potential that reproduces the full many-body spectrum. Yet, the ground state is well beyond a static one-particle description. The emerging picture gives a non-trivial answer to the decade-old question of the nature of the insulator, which we characterize as a ``many-body Peierls'' state.Comment: 5 pages, 4 color figure

Report of the Terrestrial Bodies Science Working Group. Volume 4: The moon

A rationale for furture exploration of the moon is given. Topics discussed include the objectives of the lunar polar orbiter mission, the mission profile, and general characteristics of the spacraft to be used