Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the ageing of constituent networks

The analysis of network topology and dynamics is increasingly used for the description of the structure, function and evolution of complex systems. Here we summarize key aspects of the evolvability and robustness of the hierarchical network-set of macromolecules, cells, organisms, and ecosystems. Listing the costs and benefits of cooperation as a necessary behaviour to build this network hierarchy, we outline the major hypothesis of the paper: the emergence of hierarchical complexity needs cooperation leading to the ageing of the constituent networks. Local cooperation in a stable environment may lead to over-optimization developing an ‘always-old’ network, which ages slowly, and dies in an apoptosis-like process. Global cooperation by exploring a rapidly changing environment may cause an occasional over-perturbation exhausting system-resources, causing rapid degradation, ageing and death of an otherwise ‘forever-young’ network in a necrosis-like process. Giving a number of examples we explain how local and global cooperation can both evoke and help successful ageing. Finally, we show how various forms of cooperation and consequent ageing emerge as key elements in all major steps of evolution from the formation of protocells to the establishment of the globalized, modern human society. Thus, ageing emerges as a price of complexity, which is going hand-in-hand with cooperation enhancing each other in a successful community

A first course in feedback, dynamics and control: findings from an online pilot survey for the IFAC community

Undergraduate students in many engineering programs around the world take only one control course. The IFAC Educational Committee has developed and piloted to a limited audience a comprehensive survey for the topics to be included in such course. This issue is relevant to both academia and industry. The paper discusses the initial findings related to the design of the survey as well as the responses of the participants. The findings will be used to refine the survey and distribute it in the near future to the global control community

Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function. Hypotheses and a comprehensive review

During the last decade, network approaches became a powerful tool to describe protein structure and dynamics. Here we review the links between disordered proteins and the associated networks, and describe the consequences of local, mesoscopic and global network disorder on changes in protein structure and dynamics. We introduce a new classification of protein networks into ‘cumulus-type’, i.e., those similar to puffy (white) clouds, and ‘stratus-type’, i.e., those similar to flat, dense (dark) low-lying clouds, and relate these network types to protein disorder dynamics and to differences in energy transmission processes. In the first class, there is limited overlap between the modules, which implies higher rigidity of the individual units; there the conformational changes can be described by an ‘energy transfer’ mechanism. In the second class, the topology presents a compact structure with significant overlap between the modules; there the conformational changes can be described by ‘multi-trajectories’; that is, multiple highly populated pathways. We further propose that disordered protein regions evolved to help other protein segments reach ‘rarely visited’ but functionally-related states. We also show the role of disorder in ‘spatial games’ of amino acids; highlight the effects of intrinsically disordered proteins (IDPs) on cellular networks and list some possible studies linking protein disorder and protein structure networks

Fast magnetic reconnection in free space: self-similar evolution process

We present a new model for time evolution of fast magnetic reconnection in free space, which is characterized by self-similarity. Reconnection triggered by locally enhanced resistivity assumed at the center of the current sheet can self-similarly and unlimitedly evolve until external factors affect the evolution. The possibility and stability of this type of evolution are verified by numerical simulations in a very wide spatial dynamic range. Actual astrophysical reconnection in solar flares and geomagnetospheric substorms can be treated as an evolutionary process in free space, because the resultant scale is much larger than the initial scale. In spite of this fact, most of the previous numerical works focused on the evolutionary characters strongly affected by artificial boundary conditions on the simulation boundary. Our new model clarifies a realistic evolution for such cases. The characteristic structure around the diffusion region is quite similar to the Petschek model which is characterized by a pair of slow-mode shocks and the fast-mode rarefaction-dominated inflow. However, in the outer region, a vortex-like return flow driven by the fast-mode compression caused by the piston effect of the plasmoid takes place. The entire reconnection system expands self-similarly.Comment: 17 Pages, 17 Figure

Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study

There are a great number of reports with assertions that oxidative stress is produced by organophosphorus compound (OPC) poisoning and is a cofactor of mortality and morbidity in OPC toxicity. In addition, antioxidants have been suggested as adjuncts to standard therapy. However, there is no substantial evidence for the benefit of the use of antioxidants in survival after acute intoxication of OPCs. The present study was conducted to assess the effectiveness of three non-enzymatic antioxidants (NEAOs), N-acetylcysteine (NAC), glutathione (GSH), and ascorbic acid (AA), in acute intoxication of adult male Wister rats with paraoxon. The efficacy of the antioxidants was estimated as both a pretreatment and a concurrent application along with the standard oxime, pralidoxime (2-PAM). Relative risk of death after 48 hours of application was estimated by Cox regression analysis. The results revealed no benefit of either tested NEAO to the improvement in survival of experimental rats. The application of these antioxidants was found to be deleterious when administered along with pralidoxime compared to the treatment with pralidoxime alone. It has been concluded that the tested non-enzymatic antioxidants are not useful in acute toxicity for improving survival rates. However, the individual toxic dynamics of diversified OPCs should not be overlooked and further studies with different OPCs are suggested