Measurement of the current-phase relation of superconducting atomic contacts

We have probed the current-phase relation of an atomic contact placed with a tunnel junction in a small superconducting loop. The measurements are in quantitative agreement with the predictions of a resistively shunted SQUID model in which the Josephson coupling of the contact is calculated using the independently determined transmissions of its conduction channels.Comment: to be published in Physical Review Letter

Murine and human myogenic cells identified by elevated aldehyde dehydrogenase activity: Implications for muscle regeneration and repair

Background: Despite the initial promise of myoblast transfer therapy to restore dystrophin in Duchenne muscular dystrophy patients, clinical efficacy has been limited, primarily by poor cell survival post-transplantation. Murine muscle derived stem cells (MDSCs) isolated from slowly adhering cells (SACs) via the preplate technique, induce greater muscle regeneration than murine myoblasts, primarily due to improved post-transplantation survival, which is conferred by their increased stress resistance capacity. Aldehyde dehydrogenase (ALDH) represents a family of enzymes with important morphogenic as well as oxidative damage mitigating roles and has been found to be a marker of stem cells in both normal and malignant tissue. In this study, we hypothesized that elevated ALDH levels could identify murine and human muscle derived cell (hMDC) progenitors, endowed with enhanced stress resistance and muscle regeneration capacity. Methodology/Principal Findings: Skeletal muscle progenitors were isolated from murine and human skeletal muscle by a modified preplate technique and unfractionated enzymatic digestion, respectively. ALDHhisubpopulations isolated by fluorescence activate cell sorting demonstrated increased proliferation and myogenic differentiation capacities compared to their ALDHlocounterparts when cultivated in oxidative and inflammatory stress media conditions. This behavior correlated with increased intracellular levels of reduced glutathione and superoxide dismutase. ALDHhimurine myoblasts were observed to exhibit an increased muscle regenerative potential compared to ALDHlomyoblasts, undergo multipotent differentiation (osteogenic and chondrogenic), and were found predominately in the SAC fraction, characteristics that are also observed in murine MDSCs. Likewise, human ALDHhihMDCs demonstrated superior muscle regenerative capacity compared to ALDHlohMDCs. Conclusions: The methodology of isolating myogenic cells on the basis of elevated ALDH activity yielded cells with increased stress resistance, a behavior that conferred increased regenerative capacity of dystrophic murine skeletal muscle. This result demonstrates the critical role of stress resistance in myogenic cell therapy as well as confirms the role of ALDH as a marker for rapid isolation of murine and human myogenic progenitors for cell therapy. © 2011 Vella et al

On the central quadric ansatz: integrable models and Painleve reductions

It was observed by Tod and later by Dunajski and Tod that the Boyer-Finley (BF) and the dispersionless Kadomtsev-Petviashvili (dKP) equations possess solutions whose level surfaces are central quadrics in the space of independent variables (the so-called central quadric ansatz). It was demonstrated that generic solutions of this type are described by Painleve equations PIII and PII, respectively. The aim of our paper is threefold: -- Based on the method of hydrodynamic reductions, we classify integrable models possessing the central quadric ansatz. This leads to the five canonical forms (including BF and dKP). -- Applying the central quadric ansatz to each of the five canonical forms, we obtain all Painleve equations PI - PVI, with PVI corresponding to the generic case of our classification. -- We argue that solutions coming from the central quadric ansatz constitute a subclass of two-phase solutions provided by the method of hydrodynamic reductions.Comment: 12 page

Estimating the number of change-points in a two-dimensional segmentation model without penalization

In computational biology, numerous recent studies have been dedicated to the analysis of the chromatin structure within the cell by two-dimensional segmentation methods. Motivated by this application, we consider the problem of retrieving the diagonal blocks in a matrix of observations. The theoretical properties of the least-squares estimators of both the boundaries and the number of blocks proposed by L\'evy-Leduc et al. [2014] are investigated. More precisely, the contribution of the paper is to establish the consistency of these estimators. A surprising consequence of our results is that, contrary to the onedimensional case, a penalty is not needed for retrieving the true number of diagonal blocks. Finally, the results are illustrated on synthetic data.Comment: 30 pages, 8 figure

Non-degenerate, three-wave mixing with the Josephson ring modulator

The Josephson ring modulator (JRM) is a device, based on Josephson tunnel junctions, capable of performing non-degenerate mixing in the microwave regime without losses. The generic scattering matrix of the device is calculated by solving coupled quantum Langevin equations. Its form shows that the device can achieve quantum-limited noise performance both as an amplifier and a mixer. Fundamental limitations on simultaneous optimization of performance metrics like gain, bandwidth and dynamic range (including the effect of pump depletion) are discussed. We also present three possible integrations of the JRM as the active medium in a different electromagnetic environment. The resulting circuits, named Josephson parametric converters (JPC), are discussed in detail, and experimental data on their dynamic range are found to be in good agreement with theoretical predictions. We also discuss future prospects and requisite optimization of JPC as a preamplifier for qubit readout applications.Comment: 21 pages, 16 figures, 4 table

Contact resistance and shot noise in graphene transistors

Potential steps naturally develop in graphene near metallic contacts. We investigate the influence of these steps on the transport in graphene Field Effect Transistors. We give simple expressions to estimate the voltage-dependent contribution of the contacts to the total resistance and noise in the diffusive and ballistic regimes.Comment: 6 pages, 4 figures; Figs 3 and 4 completed and appendix adde

Observing quantum state diffusion by heterodyne detection of fluorescence

A qubit can relax by fluorescence, which prompts the release of a photon into its electromagnetic environment. By counting the emitted photons, discrete quantum jumps of the qubit state can be observed. The succession of states occupied by the qubit in a single experiment, its quantum trajectory, depends in fact on the kind of detector. How are the quantum trajectories modified if one measures continuously the amplitude of the fluorescence field instead? Using a superconducting parametric amplifier, we have performed heterodyne detection of the fluorescence of a superconducting qubit. For each realization of the measurement record, we can reconstruct a different quantum trajectory for the qubit. The observed evolution obeys quantum state diffusion, which is characteristic of quantum measurements subject to zero point fluctuations. Independent projective measurements of the qubit at various times provide a quantitative validation of the reconstructed trajectories. By exploring the statistics of quantum trajectories, we demonstrate that the qubit states span a deterministic surface in the Bloch sphere at each time in the evolution. Additionally, we show that when monitoring fluorescence, coherent superpositions are generated during the decay from excited to ground state. Counterintuitively, measuring light emitted during relaxation can give rise to trajectories with increased excitation probability.Comment: Supplementary material can be found in the ancillary sectio

Generating Entangled Microwave Radiation Over Two Transmission Lines

Using a superconducting circuit, the Josephson mixer, we demonstrate the first experimental realization of spatially separated two-mode squeezed states of microwave light. Driven by a pump tone, a first Josephson mixer generates, out of quantum vacuum, a pair of entangled fields at different frequencies on separate transmission lines. A second mixer, driven by a $\pi$-phase shifted copy of the first pump tone, recombines and disentangles the two fields. The resulting output noise level is measured to be lower than for vacuum state at the input of the second mixer, an unambiguous proof of entanglement. Moreover, the output noise level provides a direct, quantitative measure of entanglement, leading here to the demonstration of 6 Mebit.s$^{-1}$ (Mega entangled bits per second) generated by the first mixer.Comment: 5 pages, 4 figures. Supplementary Information can be found here as an ancillary fil