Effect of combined use of L carnitine and hemodialysis on clinical efficacy and quality of life of uremic patients

Purpose: To investigate the clinical efficacy of combined use of L-carnitine and hemodialysis in the treatment of uremic patients, and its effect on their quality of life. Methods: A total of 160 uremic patients who were admitted to Lujiang County People's Hospital from November 2018 to August 2020 were selected and divided equally into dialysis group (hemodialysis), and combined group (L-carnitine + hemodialysis). Some clinical indices and parameters, including safety profile, National Institutes of Health Stroke Scale (NIHSS) score, CD4+ and CD4+/CD8+, and plasma protein levels were evaluated for both study groups. Results: Patients treated with L-carnitine + hemodialysis in the combined group resulted in significantly higher clinical treatment effectiveness than those in the dialysis group (p < 0.05). However, safety profiles were comparable in the two groups (p > 0.05). No significant difference in NIHSS score between the two groups before treatment, but L-carnitine + hemodialysis led to a better NIHSS score than in the dialysis group after treatment (p < 0.05). However, there were better levels of CD4+ and CD4+/CD8+ in the combined group than in the dialysis group (p < 0.05). Similarly, although pre-treatment plasma protein levels in the two groups were comparable, there were significantly lower plasma protein levels in the combined group than in the dialysis group post-treatment (p < 0.05). Conclusion: The combination of L-carnitine and hemodialysis in the treatment of uremia patients improves the clinical management of the patients, enhances their quality of life, and shows good safety profile. However, further clinical trials should be carried out prior to the application of the combined treatment in clinical practice

A Novel Ranging Method Based on RSSI

AbstractThe ranging technique based on RSSI is often used in localization of wireless sensor network (WSN). Due to external interferences, the RSSI fluctuates a lot and then a novel ranging method is presented. It establishes a database of mapping relationship between the RSSI and the distance range, then the distance between the transmitter and the receiver can be drawn by summing weighted of the distance spaces obtained through querying the mapping database. Simulation results show that,this method can eliminate the negative effects on RSSI fluctuation as much as possible and provides high ranging precision. It's no environmental limitations and can be applied in range-based localization technique with high value

Existence of Positive Periodic Solutions for n

In this paper we consider the existence, multiplicity, and nonexistence of positive periodic solutions for n-dimensional nonautonomous functional differential system x'(t)=H(t,x(t))-λB(t)F(x(t-τ(t))), where hi are ω-periodic in t and there exist ω-periodic functions αi,βi∈C(R,R+) such that αi(t)≤(hi(t,x)/xi)≤βi(t),∫0ω‍αi(t)dt>0, for x∈R+n all with xi>0, and t∈R, limxi→0+(hi(t,x)/xi) exist for t∈R; bi∈C(R,R+) are ω-periodic functions and ∫0ω‍bi(t)dt>0;fi∈C(R+n,R+), fi(x)>0 for x >0; τ∈(R,R) is an ω-periodic function. We show that the system has multiple or no positive ω-periodic solutions for sufficiently large or small λ>0, respectively

Frequency Enhanced Hybrid Attention Network for Sequential Recommendation

The self-attention mechanism, which equips with a strong capability of modeling long-range dependencies, is one of the extensively used techniques in the sequential recommendation field. However, many recent studies represent that current self-attention based models are low-pass filters and are inadequate to capture high-frequency information. Furthermore, since the items in the user behaviors are intertwined with each other, these models are incomplete to distinguish the inherent periodicity obscured in the time domain. In this work, we shift the perspective to the frequency domain, and propose a novel Frequency Enhanced Hybrid Attention Network for Sequential Recommendation, namely FEARec. In this model, we firstly improve the original time domain self-attention in the frequency domain with a ramp structure to make both low-frequency and high-frequency information could be explicitly learned in our approach. Moreover, we additionally design a similar attention mechanism via auto-correlation in the frequency domain to capture the periodic characteristics and fuse the time and frequency level attention in a union model. Finally, both contrastive learning and frequency regularization are utilized to ensure that multiple views are aligned in both the time domain and frequency domain. Extensive experiments conducted on four widely used benchmark datasets demonstrate that the proposed model performs significantly better than the state-of-the-art approaches.Comment: 11 pages, 7 figures, The 46th International ACM SIGIR Conference on Research and Development in Information Retrieva

L1-ORF1p and Ago2 are involved in a siRNA-mediated regulation for promoter activity of L1-5’UTR

Introduction. Long interspersed nuclear elements-1 (L1), as the only one self-active retrotransposon of the mobile element, was found to be generally activated in tumor cells. The 5‘UTR of L1 (L1-5’UTR) contains both sense and antisense bidirectional promoters, transcription products of which can generate double-strand RNA (dsRNA). In addition, L1-ORF1p, a dsRNA binding protein encoded by L1, is considered to engage in some RNA-protein (RNP) formation. Ago2, one of the RISC components, can bind to dsRNA to form RISC complex, but its role in L1 regulation still remains unclear. Due that the 5‘UTR of L1 (L1-5’UTR) contains both sense and antisense bidirectional promoters, so the activities in both string were identified. A dsRNA-mediated regulation of L1-5’UTR, with the feedback regulation of L1-ORF1p as well as other key molecules engaged (Ago1–4) in this process, was also investigated. Material and methods. Genomic DNA was extracted from HEK293 cells and subjected to L1-5’UTR prepa­ration by PCR. Report gene system pIRESneo with SV40 promoter was employed. The promoter activities of different regions in L1-5’UTR were identified by constructing these regions into pIRESneo, which SV40 region was removed prior, to generate different recombinant plasmids. The promoter activities in recombinant plasmids were detected by the luciferase expression assay. Western blot and co-immunoprecipitation were employed to identify proteins expression and protein-protein interaction respectively. Results. Ago2 is a member of Agos family, which usually forms a RISC complex with si/miRNA and is involved in post- transcriptional regulation of many genes. Here L1-ORF1p and Ago2 conducts a regulation as a negative feedback for L1-5'UTR sense promoter. L1-ORF1p could form the immune complexes with Ago1, Ago2 and Ago4, respectively. Conclusions. L1-5’UTR harbors both sense and antisense promoter activity and a dsRNA-mediated regulation is responsible for L1-5’UTR regulation. Agos proteins and L1-ORF1p were engaged in this process