Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow.

The functions of blood flow in the morphogenesis of mammalian arteries and veins are not well understood. We examined the development of the dorsal aorta (DA) and the cardinal vein (CV) in Ncx1 -/- mutants, which lack blood flow due to a deficiency in a sodium calcium ion exchanger expressed specifically in the heart. The mutant DA and CV were abnormally connected. The endothelium of the Ncx1 -/- mutant DA lacked normal expression of the arterial markers ephrin-B2 and Connexin-40. Notch1 activation, known to promote arterial specification, was decreased in mutant DA endothelial cells (ECs), which ectopically expressed the venous marker Coup-TFII. These findings suggest that flow has essential functions in the DA by promoting arterial and suppressing venous marker expression. In contrast, flow plays a lesser role in the CV, because expression of arterial-venous markers in CV ECs was not as dramatically affected in Ncx1 -/- mutants. We propose a molecular mechanism by which blood flow mediates DA and CV morphogenesis, by regulating arterial-venous specification of DA ECs to ensure proper separation of the developing DA and CV

Integration of corporate social responsibility into new product development

This study investigated seven core subjects of ISO 26000 to explore the way in which new product development (NPD) links corporate social responsibility (CSR) strategy with product development planning. This study thoroughly discussed the implementation of policies that achieve social responsibility within the context of NPD planning. Rapid changes in science and technology mean customer needs are changing faster than ever before, making it increasingly difficult to identify critical customer needs in a timely manner. NPD therefore is essential to enhance enterprise competitiveness. The construction of a CSR-based NPD model can help enterprises in NPD. Using the CSR based NPD model to plan materials selection, specification setting, manufacturing procedures and methods, distribution, servicing and recycling increases enterprise friendliness and happiness, and benefits their sustainable development. The findings of this study suggest that traditional enterprise activities focus on profit maximization and cost minimization. The profit-oriented strategy influences product design, purchase, production, manufacture and delivery. Poor working environment, overtime, low wages, neglect of health and safety, and various deficiencies in CSR frequently occur. If a CSR based perspective is initially adopted to implement public expectations regarding product design, it can be both beneficial and environmentally friendly

Association between health examination items and body mass index among school children in Hualien, Taiwan

BACKGROUND: To assess the prevalence of obesity and major physical examination items including dental caries, myopia, pinworm, hematuria, and proteinuria among school children in Hualien, Taiwan. In addition, the health status differences between gender, grader, levels of residence urbanization, and body mass index (BMI) were examined. METHODS: Cross-sectional studies with a total of 11,080 students (age, 7–14 years) in grades 1, 4, and 7 were evaluated for weight, height, routine physical examination, and urine analysis during the 2010 Student Health Examination in Hualien. Frequencies, Chi-square test, and logistic regression were conducted using SPSS. RESULTS: Of the 11,080 students evaluated, 1357 (12.2%) were overweight, and 1421 (12.8%) were obese. There were significant differences in overweight/obese prevalence by gender, by grader, and by levels of residence urbanization. Dental caries, myopia, and obesity were the most prevalent health problems among these students (75.6%, 33.0%, and 12.8%, respectively). In crude and adjusted analyses, research results showed that there were significant differences in the prevalence of major physical examination items between different gender, grader, levels of residence urbanization, and BMI groups. Girls had a higher prevalence of dental caries, myopia, and hematuria than boys (all p < 0.01), whereas boys had a higher prevalence of pinworm than girls (p = 0.02). Students in higher grades had significantly higher prevalence of myopia, hematuria, and proteinuria (all p < 0.01), whereas students in lower grades had higher prevalence of dental caries and pinworm (p < 0.01). Students with abnormal BMI had lower prevalence of pinworm (p < 0.01). Students residing in suburban and rural areas had higher prevalence of dental caries, pinworm, and hematuria (all p < 0.01), and lower prevalence of myopia than students residing in urban areas (all p < 0.01). CONCLUSION: Routine health examination provides an important way to detect students’ health problems. Our study elucidated major health problems among school children in Hualien, Taiwan. In addition, the results also indicated that the prevalence of health problems had a significant relationship with gender, grader, levels of residence urbanization, and BMI. It is suggested that school health interventions should consider students’ health profiles along with their risk factors status in planning

The genome sequence of the orchid Phalaenopsis equestris

Orchidaceae, renowned for its spectacular flowers and other reproductive and ecological adaptations, is one of the most diverse plant families. Here we present the genome sequence of the tropical epiphytic orchid Phalaenopsis equestris, a frequently used parent species for orchid breeding. P. equestris is the first plant with crassulacean acid metabolism (CAM) for which the genome has been sequenced. Our assembled genome contains 29,431 predicted protein-coding genes. We find that contigs likely to be underassembled, owing to heterozygosity, are enriched for genes that might be involved in self-incompatibility pathways. We find evidence for an orchid-specific paleopolyploidy event that preceded the radiation of most orchid clades, and our results suggest that gene duplication might have contributed to the evolution of CAM photosynthesis in P. equestris. Finally, we find expanded and diversified families of MADS-box C/D-class, B-class AP3 and AGL6-class genes, which might contribute to the highly specialized morphology of orchid flowers. (Résumé d'auteur

Multi-objective job-shop scheduling with lot-splitting production

While focusing on lot splitting in the job-shop scheduling problem, this study attempts to minimize the weighted total of stock, machine idle and carrying costs. Stock cost is determined using processing time. Machine idle cost is estimated using machine idle time. Carrying cost is calculated using the carry number of lot splitting. Results of this study demonstrate that stock cost and machine idle cost are inversely related to the number of lots split and have marginal decreasing result of benefit. The benefit of processing time is not as apparent as that of count and increase in turn. Carrying cost is positively related to the number of lots split. The minimum weighted total cost of stock, machine idle and carrying costs typically appears when the number of lots split is 2 or 3. The ant colony optimization (ACO) algorithm is used to solve the job-shop scheduling problem. Compared with the solution obtained by LINGO, the ACO algorithm performs well in scheduling and uses less time to solve the problem.Ant colony optimization Lot-splitting Job-shop scheduling

Clarifying Cutting and Sewing Processes with Due Windows Using an Effective Ant Colony Optimization

The cutting and sewing process is a traditional flow shop scheduling problem in the real world. This two-stage flexible flow shop is often commonly associated with manufacturing in the fashion and textiles industry. Many investigations have demonstrated that the ant colony optimization (ACO) algorithm is effective and efficient for solving scheduling problems. This work applies a novel effective ant colony optimization (EACO) algorithm to solve two-stage flexible flow shop scheduling problems and thereby minimize earliness, tardiness, and makespan. Computational results reveal that for both small and large problems, EACO is more effective and robust than both the particle swarm optimization (PSO) algorithm and the ACO algorithm. Importantly, this work demonstrates that EACO can solve complex scheduling problems in an acceptable period of time

Rolling Supply Chain Scheduling considering Suppliers, Production, and Delivery Lot-Size

Supply chain management and integration play a key factor in contemporary manufacturing concept. Companies seek to integrate itself within a cooperative and mutual benefiting supply chain. Supply chain scheduling, as an important aspect of supply chain management, highly emphasizes on minimizing stock costs and delivery costs. Most previous researches on supply chain scheduling problems assume make-to-order production, which includes delivery cost in lot-size. This practice simplifies the complexity of the problem. Instead, this research discusses make-to-contract production, where the supply chain has a rolling planning horizon that changes according to contracts. Within a planning horizon, two types of interval are defined. The first is frozen interval, in which the manufacturing decision cannot be changed. The second is free interval, where schedules can be adjusted depending on new contracts. This research aims to build a robust rolling supply management schedule to satisfy customers’ needs, by considering supplier, production, and delivery lot-size simultaneously. The objective is to effectively decide a combination of supplier, production, and delivery lot-size that minimizes total cost consisting of supplier cost, finish good stock cost, and delivery cost. Based on the concept, this study designs a problem-solving process that combines the methods of rolling planning horizon and genetic algorithm. Delivery size (DS), finish good stock (FS), and early delivery cost (ED) are the three methods applied; each will provide a guideline to produce a feasible solution. By further considering the fluctuations in practical needs and performing an overall evaluation, a robust and optimal supply chain scheduling plan can be decided, including the optimal lot-sizes of supplier, production, and delivery. In the effectiveness test which considers 3 types of customer demands and 11 types of company cost structures, the simulated data test results suggest that the proposed methods in this study have excellent performance