Modeling radiation belt radial diffusion in ULF wave fields: 1. Quantifying ULF wave power at geosynchronous orbit in observations and in global MHD model

[1] To provide critical ULF wave field information for radial diffusion studies in the radiation belts, we quantify ULF wave power (f = 0.5–8.3 mHz) in GOES observations and magnetic field predictions from a global magnetospheric model. A statistical study of 9 years of GOES data reveals the wave local time distribution and power at geosynchronous orbit in field-aligned coordinates as functions of wave frequency, solar wind conditions (Vx, ΔPd and IMF Bz) and geomagnetic activity levels (Kp, Dst and AE). ULF wave power grows monotonically with increasing solar wind Vx, dynamic pressure variations ΔPd and geomagnetic indices in a highly correlated way. During intervals of northward and southward IMF Bz, wave activity concentrates on the dayside and nightside sectors, respectively, due to different wave generation mechanisms in primarily open and closed magnetospheric configurations. Since global magnetospheric models have recently been used to trace particles in radiation belt studies, it is important to quantify the wave predictions of these models at frequencies relevant to electron dynamics (mHz range). Using 27 days of real interplanetary conditions as model inputs, we examine the ULF wave predictions modeled by the Lyon-Fedder-Mobarry magnetohydrodynamic code. The LFM code does well at reproducing, in a statistical sense, the ULF waves observed by GOES. This suggests that the LFM code is capable of modeling variability in the magnetosphere on ULF time scales during typical conditions. The code provides a long-missing wave field model needed to quantify the interaction of radiation belt electrons with realistic, global ULF waves throughout the inner magnetosphere

Evolution of plant senescence

BACKGROUND: Senescence is integral to the flowering plant life-cycle. Senescence-like processes occur also in non-angiosperm land plants, algae and photosynthetic prokaryotes. Increasing numbers of genes have been assigned functions in the regulation and execution of angiosperm senescence. At the same time there has been a large expansion in the number and taxonomic spread of plant sequences in the genome databases. The present paper uses these resources to make a study of the evolutionary origins of angiosperm senescence based on a survey of the distribution, across plant and microbial taxa, and expression of senescence-related genes. RESULTS: Phylogeny analyses were carried out on protein sequences corresponding to genes with demonstrated functions in angiosperm senescence. They include proteins involved in chlorophyll catabolism and its control, homeoprotein transcription factors, metabolite transporters, enzymes and regulators of carotenoid metabolism and of anthocyanin biosynthesis. Evolutionary timelines for the origins and functions of particular genes were inferred from the taxonomic distribution of sequences homologous to those of angiosperm senescence-related proteins. Turnover of the light energy transduction apparatus is the most ancient element in the senescence syndrome. By contrast, the association of phenylpropanoid metabolism with senescence, and integration of senescence with development and adaptation mediated by transcription factors, are relatively recent innovations of land plants. An extended range of senescence-related genes of Arabidopsis was profiled for coexpression patterns and developmental relationships and revealed a clear carotenoid metabolism grouping, coordinated expression of genes for anthocyanin and flavonoid enzymes and regulators and a cluster pattern of genes for chlorophyll catabolism consistent with functional and evolutionary features of the pathway. CONCLUSION: The expression and phylogenetic characteristics of senescence-related genes allow a framework to be constructed of decisive events in the evolution of the senescence syndrome of modern land-plants. Combining phylogenetic, comparative sequence, gene expression and morphogenetic information leads to the conclusion that biochemical, cellular, integrative and adaptive systems were progressively added to the ancient primary core process of senescence as the evolving plant encountered new environmental and developmental contexts

Sequencing of idiopathic pulmonary fibrosis-related genes reveals independent single gene associations

BACKGROUND: Previous studies investigating a genetic basis for idiopathic pulmonary fibrosis (IPF) have focused on resequencing single genes in IPF kindreds or cohorts to determine the genetic contributions to IPF. None has investigated interactions among the candidate genes. OBJECTIVE: To compare the frequencies and interactions of mutations in six IPF-associated genes in a cohort of 132 individuals with IPF with those of a disease-control cohort of 192 individuals with chronic obstructive pulmonary disease (COPD) and the population represented in the Exome Variant Server. METHODS: We resequenced the genes encoding surfactant proteins A2 (SFTPA2), and C (SFTPC), the ATP binding cassette member A3 (ABCA3), telomerase (TERT), thyroid transcription factor (NKX2-1) and mucin 5B (MUC5B) and compared the collapsed frequencies of rare (minor allele frequency <1%), computationally predicted deleterious variants in each cohort. We also genotyped a common MUC5B promoter variant that is over-represented in individuals with IPF. RESULTS: We found 15 mutations in 14 individuals (11%) in the IPF cohort: (SFTPA2 (n=1), SFTPC (n=5), ABCA3 (n=4) and TERT (n=5)). No individual with IPF had two different mutations, but one individual with IPF was homozygous for p.E292V, the most common ABCA3 disease-causing variant. We did not detect an interaction between any of the mutations and the MUC5B promoter variant. CONCLUSIONS: Rare mutations in SFTPA2, SFTPC and TERT are collectively over-represented in individuals with IPF. Genetic analysis and counselling should be considered as part of the IPF evaluation

A stochastic model of Min oscillations in Escherichia coli and Min protein segregation during cell division

The Min system in Escherichia coli directs division to the centre of the cell through pole-to-pole oscillations of the MinCDE proteins. We present a one dimensional stochastic model of these oscillations which incorporates membrane polymerisation of MinD into linear chains. This model reproduces much of the observed phenomenology of the Min system, including pole-to-pole oscillations of the Min proteins. We then apply this model to investigate the Min system during cell division. Oscillations continue initially unaffected by the closing septum, before cutting off rapidly. The fractions of Min proteins in the daughter cells vary widely, from 50%-50% up to 85%-15% of the total from the parent cell, suggesting that there may be another mechanism for regulating these levels in vivo.Comment: 19 pages, 12 figures (25 figure files); published at http://www.iop.org/EJ/journal/physbi

Hydrogenation of Mg film and Mg nanoblade array on Ti coated Si substrates

The hydrogenation of Mg film and Mg nanoblade array fabricated on Ti coated Si substrates has been studied and compared. The nanoblades start to absorb hydrogen at a temperature between 250 and 300 degrees C, which is much lower than 350 degrees C for Mg film. However, the saturated total hydrogen uptake in nanoblades is less than half of that in the film, resulting from MgO formation by air exposure. The nanoblade morphology with large surface area and small hydrogen diffusion length, and the catalytic effect of Ti layer, are two main reasons for the nanoblade hydrogenation behavior

Reducing multiphoton ionization in a linearly polarized microwave field by local control

We present a control procedure to reduce the stochastic ionization of hydrogen atom in a strong microwave field by adding to the original Hamiltonian a comparatively small control term which might consist of an additional set of microwave fields. This modification restores select invariant tori in the dynamics and prevents ionization. We demonstrate the procedure on the one-dimensional model of microwave ionization.Comment: 8 page

Continuous Operator Authentication for Teleoperated Systems Using Hidden Markov Models [post-print]

In this article, we present a novel approach for continuous operator authentication in teleoperated robotic processes based on Hidden Markov Models (HMM). While HMMs were originally developed and widely used in speech recognition, they have shown great performance in human motion and activity modeling. We make an analogy between human language and teleoperated robotic processes (i.e., words are analogous to a teleoperator\u27s gestures, sentences are analogous to the entire teleoperated task or process) and implement HMMs to model the teleoperated task. To test the continuous authentication performance of the proposed method, we conducted two sets of analyses. We built a virtual reality (VR) experimental environment using a commodity VR headset (HTC Vive) and haptic feedback enabled controller (Sensable PHANToM Omni) to simulate a real teleoperated task. An experimental study with 10 subjects was then conducted. We also performed simulated continuous operator authentication by using the JHU-ISI Gesture and Skill Assessment Working Set (JIGSAWS). The performance of the model was evaluated based on the continuous (real-time) operator authentication accuracy as well as resistance to a simulated impersonation attack. The results suggest that the proposed method is able to achieve 70% (VR experiment) and 81% (JIGSAWS dataset) continuous classification accuracy with as short as a 1-second sample window. It is also capable of detecting an impersonation attack in real-time

Direct Simulation of the Motion of Solid Particles in Couette and Poiseuille Flows of Viscoelastic Fluids

This paper reports the results of direct numerical simulation of the motion of a two-dimensional circular cylinder in Couette flow and in Poiseuille flow of an Oldroyd-B fluid. Both neutrally buoyant and non-neutrally buoyant cylinders are considered. The cylinder\u27s motion and the mechanisms which cause the cylinders to migrate are studied. The stable equilibrium position of neutrally buoyant particles varies with inertia, elasticity, shear thinning and the blockage ratio of the channel in both shear flows. Shear thinning promotes the migration of the cylinder to the wall while inertia causes the cylinder to migrate away from the wall. The cylinder moves closer to the wall in a narrower channel. In a Poiseuille flow, the effect of elastic normal stresses is manifested by an attraction toward the nearby wall if the blockage is strong. If the blockage is weak, the normal stresses act through the curvature of the inflow velocity profile and generate a lateral force that points to the centreline. In both cases, the migration of particles is controlled by elastic normal stresses which in the limit of slow flow in two dimensions are compressive and proportional to the square of the shear rate on the body. A slightly buoyant cylinder in Couette flow migrates to an equilibrium position nearer the centreline of the channel in a viscoelastic fluid than in a Newtonian fluid. On the other hand, the same slightly buoyant cylinder in Poiseuille flow moves to a stable position farther away from the centreline of the channel in a viscoelastic fluid than in a Newtonian fluid. Marked effects of shear thinning are documented and discussed

Sintering Metal Nanoparticle Films

We have carried out several measurements in order to understand the process of metal nanoparticle (MNP) film sintering. Small angle neutron scattering has been used to reveal the average diameters of silver and gold nanoparticles (Ag-NPs and Au-NPs) used in this study to be 4.6 and 3.8 nm, respectively, with a size distribution of ca. 20%. Spun- cast Ag-NP and Au-NP films have been sintered at temperature ranges of 80-160ºC and 180-210º, respectively, for various times. The resulting film composition, morphology and electric resistance have been revealed. Upon sintering, the organic content in MNP films reduces to less than 10% while the overall film thickness reduces to about the half of the as-cast film thickness. The resistance of sintered Ag-NP films can vary over more than 7 decades depending on the sintering temperature. The conductivity of Ag-NP films sintered at 150º is 2.4 times 10-8Ωm. The transport properties are affected by both the composition and morphology of sintered films