Charged charmoniumlike structures in the e+e−→ψ(3686)π+π−e^+ e^- \to \psi(3686) \pi^+ \pi^- process based on the ISPE mechanism

In 2017, the BESIII Collaboration announced the observation of a charged charmonium-like structure in the $\psi(3686)\pi^\pm$ invariant mass spectrum of the $e^+ e^- \to \psi(3686) \pi^+ \pi^-$ process at different energy points, which enables us to perform a precise study of this process based on the initial single pion emission (ISPE) mechanism. In this work, we perform a combined fit to the experimental data of the cross section of $e^+ e^- \to \psi(3686) \pi^+ \pi^-$, and the corresponding $\psi(3686)\pi^\pm$ and dipion invariant mass spectra. Our result shows that the observed charged charmonium-like structure in $e^+ e^- \to \psi(3686) \pi^+ \pi^-$ can be well reproduced based on the ISPE mechanism, and that the corresponding dipion invariant mass spectrum and cross section can be depicted with the same parameters. In fact, it provides strong evidence that the ISPE mechanism can be an underlying mechanism resulting in such novel a phenomenon.Comment: 11 pages, 8 figures and 4 table

Aerodynamic Optimization Design of a Multistage Centrifugal Steam Turbine and Its Off-Design Performance Analysis

Centrifugal turbine which has less land occupation, simple structure, and high aerodynamic efficiency is suitable to be used as small to medium size steam turbines or waste heat recovery plant. In this paper, one-dimensional design of a multistage centrifugal steam turbine was performed by using in-house one-dimensional aerodynamic design program. In addition, three-dimensional numerical simulation was also performed in order to analyze design and off-design aerodynamic performance of the proposed centrifugal steam turbine. The results exhibit reasonable flow field and smooth streamline; the aerodynamic performance of the designed turbine meets our initial expectations. These results indicate that the one-dimensional aerodynamic design program is reliable and effective. The off-design aerodynamic performance of centrifugal steam turbine was analyzed, and the results show that the mass flow increases with the decrease of the pressure ratio at a constant speed, until the critical mass flow is reached. The efficiency curve with the pressure ratio has an optimum efficiency point. And the pressure ratio of the optimum efficiency agrees well with that of the one-dimensional design. The shaft power decreases as the pressure ratio increases at a constant speed. Overall, the centrifugal turbine has a wide range and good off-design aerodynamic performance

Low cycle fatigue damage model and sensitivity analysis of fatigue crack initiation by finite element approach

To meet the design requirements, different types of defects are often machined on the surface of fatigue components. Local stress concentration formed at the notch accelerate the initiation of fatigue crack, therefore greatly shorten the service lives of such components. Based on the theory of continuous damage mechanics and the principle of irreversible thermodynamics, the damage evolution model of low cycle fatigue is investigated. By programming the damage evolution model as UMAT subroutine and coupling it to ABAQUS, the fatigue damage and crack initiation life of notched P92 steel samples under specific loads are simulated, and the crack initiation location is determined. Furthermore, the damage evolution and crack initiation sensitivity of notch morphology are considered. The results show that the crack initiation occurs easily in the notch root where the damage is greatest and the plastic strain accumulates fastest under cyclic loading. The fatigue damage accumulates slowly at the initial stage, but the damage accumulates rapidly after the cumulative damage reaches a critical value. The fatigue damage evolution and fatigue initiation life are very sensitive to the notch morphology parameters. The notch morphology need to be carefully analyzed, to improve the fatigue life of the notched samples

Live Cell Interferometry: A Novel Quantitative Phase Imaging Technique for Rapid Characterizations of Tumor Heterogeneity, Drug Resistance, Cell Fates and Biophysical Properties

Cell mass is an important biophysical property that provides a crucial link between external physical measurements and internal cellular processes such as cell cycle progression, division, differentiation and cell death. Advancements in quantitative phase imaging (QPI) techniques have enabled many in-depth studies of cell mass in the context of basic and translational research. This thesis describes the development and implementation of live cell interferometry (LCI) as a novel QPI technique that is high speed, high throughput, precise and label-free. It was validated as a powerful tool in dissecting tumor heterogeneity and drug resistance in patient derived melanoma cell lines. LCI analysis of cell fate in response to mitotic inhibitors provided valuable insights in cancer drug development and dose selection. Furthermore, it was utilized to characterize many other biophysical responses in fundamental research such as cardiomyocyte hypertrophy in cardiac wound healing responses. These studies showcased the unique capabilities and advantages of LCI in applications from bench to bedside

Equivariant Transporter Network

Transporter Net is a recently proposed framework for pick and place that is able to learn good manipulation policies from a very few expert demonstrations. A key reason why Transporter Net is so sample efficient is that the model incorporates rotational equivariance into the pick module, i.e. the model immediately generalizes learned pick knowledge to objects presented in different orientations. This paper proposes a novel version of Transporter Net that is equivariant to both pick and place orientation. As a result, our model immediately generalizes place knowledge to different place orientations in addition to generalizing pick knowledge as before. Ultimately, our new model is more sample efficient and achieves better pick and place success rates than the baseline Transporter Net model.Comment: Project Website: https://haojhuang.github.io/etp_page

Tetramethylpyrazine protects Schwann cells from ischemia-like injury and increases cell survival in cold ischemic rat nerves

Tetrametilpirazina (TMP), o principal componente do extrato de Ligusticum wallichi Franchat (erva chinesa), apresenta propriedades neuroprotetoras na isquemia. Nesse estudo, avaliamos seus efeitos protetores nas células de Schwann (SC), cultivando-as na presença de condições de depleção de oxigênio da glicose (OGD) e medindo a sobrevivência dos nervos de ratos isquêmicos pelo resfriamento. No modelo de lesão isquêmica em SC induzida por OGD, demonstramos que o tratamento com TMP não somente reduziu as perdas de viabilidade celular induzida por OGD, a morte celular, a apoptose de SC dose-dependente e inibiu a liberação de LDH, mas, também, suprimiu a infra-regulação do Vcl-2 e a supra-regulação de Bax e caspase-3, e inibiu a consequente ativação da caspase-3. No modelo de nervo isquêmico por resfriamento, observamos que a exposição prolongada ao resfriamento por quatro semanas estava, marcadamente, associada com a ausência de SC, com o decréscimo da viabilidade celular e a apoptose em segmentos de nervo incubados na solução da Universidade de Wisconsin apenas. Entretanto, a TMP atenuou o dano no segmento do nervo preservando SC e antagonizando a diminuição da viabilidade da fibra nervosa e o aumento das células TUNEL-positiva de modo dose-dependente. De forma conjunta, nossos resultados indicam que o TMP não só fornece efeitos protetores em um modelo de dano semelhante à isquemia de SC de ratos cultivados pela regulação de BCl-2, Bax e caspase 3, mas, também, aumenta a sobrevivência celular e suprime a apoptose no modelo de isquemia por resfriamento por exposição prolongada por quatro semanas. Então, TMP pode ser uma estratégia terapêutica eficaz para prevenir doenças isquêmicas do sistema nervoso periférico e melhora a armazenagem do nervo periférico.Tetramethylpyrazine (TMP), a major active ingredient of Ligusticum wallichi Franchat extract (a Chinese herb), exhibits neuroprotective properties in ischemia. In this study, we assessed its protective effects on Schwann cells (SCs) by culturing them in the presence of oxygen glucose deprivation (OGD) conditions and measuring cell survival in cold ischemic rat nerves. In the OGD-induced ischemic injury model of SCs, we demonstrated that TMP treatment not only reduced OGD-induced cell viability losses, cell death, and apoptosis of SCs in a dose-dependent manner, and inhibited LDH release, but also suppressed OGD-induced downregulation of Bcl-2 and upregulation of Bax and caspase-3, as well as inhibited the consequent activation of caspase-3. In the cold ischemic nerve model, we found that prolonged cold ischemic exposure for four weeks was markedly associated with the absence of SCs, a decrease in cell viability, and apoptosis in preserved nerve segments incubated in University of Wisconsin solution (UWS) alone. However, TMP attenuated nerve segment damage by preserving SCs and antagonizing the decrease in nerve fiber viability and increase in TUNEL-positive cells in a dose-dependent manner. Collectively, our results indicate that TMP not only provides protective effects in an ischemia-like injury model of cultured rat SCs by regulating Bcl-2, Bax, and caspase-3, but also increases cell survival and suppresses apoptosis in the cold ischemic nerve model after prolonged ischemic exposure for four weeks. Therefore, TMP may be a novel and effective therapeutic strategy for preventing peripheral nervous system ischemic diseases and improving peripheral nerve storage