Probing the dark sector with nuclear transition photons

Here we present world-leading sensitivity to light ($< 170$ MeV) dark matter (DM) using beam-dump experiments. Dark sector particles produced during pion decay at accelerator beam-dumps can be detected via scattering in neutrino detectors. The decay of nuclei excited by the inelastic scattering of DM is an unexploited channel which has significantly better sensitivity than similar searches using the elastic scattering channel. We show that this channel is a powerful probe of DM by demonstrating sensitivity to the thermal relic abundance benchmark in a scalar DM dark-photon portal model. This is achieved through the use of existing data, obtained by the KARMEN experiment over two decades ago, which allow us to set world-leading constraints on this model over a wide mass range. With experimental improvements planned for the future, this technique will be able to probe the thermal relic benchmark for fermionic DM across a wide mass range.Comment: 5 pages, 4 figures. V2 updated with bounds from KARMEN and projections for PIP2BD. V3 as accepted by PR

Parameterizing Majorana Neutrino Couplings in the Higgs Sector

Nonzero masses for the active neutrinos - regardless of their nature or origin - arise only after electroweak symmetry breaking. We discuss the parameterization of neutrino couplings to a Higgs sector consisting of one SU(2)_L scalar doublet and one SU(2)_L scalar triplet, and allow for right-handed neutrinos whose Majorana mass parameters arise from the vacuum expectation value of a Standard Model scalar singlet. If the neutrinos are Majorana fermions, all Yukawa couplings can be expressed as functions of the neutrino mass eigenvalues and a subset of the elements of the neutrino mixing matrix. In the mass basis, the Yukawa couplings are, in general, not diagonal. This is to be contrasted to the case of charged-fermions or Dirac neutrinos, where couplings to the Higgs-boson are diagonal in the mass basis and proportional only to the fermion masses. Nonetheless, all physically distinguishable parameters can be reached if all neutrino masses are constrained to be positive, all mixing angles constrained to lie in the first quadrant (theta in [0,pi/2]), and all Majorana phases to lie in the first two quadrants (phi in [0,pi]), as long as all Dirac phases vary within the entire unit circle (delta in [0,2pi}). We discuss several concrete examples and comment on the Casas-Ibarra parameterization for the neutrino Yukawa couplings in the case of the type-I Seesaw Lagrangian.Comment: 13 pages, 2 eps figure

IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus.

Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a major nosocomial pathogen that is widespread in both health-care facilities and in the community at large, as a result of direct host-to-host transmission. Several virulence factors are associated with pathogen transmission to naive hosts. Immunodominant surface antigen B (IsaB) is a virulence factor that helps Staphylococcus aureus to evade the host defense system. However, the mechanism of IsaB on host transmissibility remains unclear. We found that IsaB expression was elevated in transmissible MRSA. Wild-type isaB strains inhibited autophagic flux to promote bacterial survival and elicit inflammation in THP-1 cells and mouse skin. MRSA isolates with increased IsaB expression showed decreased autophagic flux, and the MRSA isolate with the lowest IsaB expression showed increased autophagic flux. In addition, recombinant IsaB rescued the virulence of the isaB deletion strain and increased the group A streptococcus (GAS) virulence in vivo. Together, these results reveal that IsaB diminishes autophagic flux, thereby allowing MRSA to evade host degradation. These findings suggest that IsaB is a suitable target for preventing or treating MRSA infection

Exciting Prospects for Dark Matter at Large-Volume Neutrino Detectors

We propose a new approach to search for light dark matter (DM) in the range of keV-GeV via inelastic nucleus scattering at large-volume neutrino detectors such as Borexino, DUNE, JUNO, and Hyper-K. The approach uses inelastic nuclear scattering of cosmic-ray boosted DM, enabling a low-background search for DM in these experiments. The large neutrino detectors with higher threshold can be used since the nuclear deexcitation lines are $O(10)$ MeV. Using a hadrophilic dark-gauge-boson-portal model as a benchmark, we show that the nuclear inelastic channels generally provide better sensitivity than the elastic scattering for a large region of light DM parameter space.Comment: 7 pages, 4 figure

Conserved Spin and Orbital Angular Momentum Hall Current in a Two-Dimensional Electron System with Rashba and Dresselhaus Spin-orbit Coupling

We study theoretically the spin and orbital angular momentum (OAM) Hall effect in a high mobility two-dimensional electron system with Rashba and Dresselhuas spin-orbit coupling by introducing both the spin and OAM torque corrections, respectively, to the spin and OAM currents. We find that when both bands are occupied, the spin Hall conductivity is still a constant (i.e., independent of the carrier density) which, however, has an opposite sign to the previous value. The spin Hall conductivity in general would not be cancelled by the OAM Hall conductivity. The OAM Hall conductivity is also independent of the carrier density but depends on the strength ratio of the Rashba to Dresselhaus spin-orbit coupling, suggesting that one can manipulate the total Hall current through tuning the Rashba coupling by a gate voltage. We note that in a pure Rashba system, though the spin Hall conductivity is exactly cancelled by the OAM Hall conductivity due to the angular momentum conservation, the spin Hall effect could still manifest itself as nonzero magnetization Hall current and finite magnetization at the sample edges because the magnetic dipole moment associated with the spin of an electron is twice as large as that of the OAM. We also evaluate the electric field-induced OAM and discuss the origin of the OAM Hall current. Finally, we find that the spin and OAM Hall conductivities are closely related to the Berry vector (or gauge) potential.Comment: latest revised version; Accepted for publication in Physical Review

Pseudo-Dirac Neutrinos in the New Standard Model

The addition of gauge singlet fermions to the Standard Model Lagrangian renders the neutrinos massive and allows one to explain all that is experimentally known about neutrino masses and lepton mixing by varying the values of the Majorana mass parameters M for the gauge singlets and the neutrino Yukawa couplings. Here we explore the region of parameter space where M values are much smaller than the neutrino Dirac masses. In this region, neutrinos are pseudo-Dirac fermions. We find that current solar data constrain M values to be less than at least 1E-9 eV, and discuss the sensitivity of future experiments to tiny gauge singlet fermion masses. We also discuss a useful basis for analyzing pseudo-Dirac neutrino mixing effects. In particular, we identify a simple relationship between elements of M and the induced enlarged mixing matrix and new mass-squared differences. These allow one to directly relate bounds on the new mass-squared differences to bounds on the singlet fermion Majorana masses.Comment: 20 Pages, 9 .eps figures, Updated reference

Drastic population fluctuations explain the rapid extinction of the passenger pigeon

To assess the role of human disturbances in species' extinction requires an understanding of the species population history before human impact. The passenger pigeon was once the most abundant bird in the world, with a population size estimated at 3-5 billion in the 1800s; its abrupt extinction in 1914 raises the question of how such an abundant bird could have been driven to extinction in mere decades. Although human exploitation is often blamed, the role of natural population dynamics in the passenger pigeon's extinction remains unexplored. Applying high-throughput sequencing technologies to obtain sequences from most of the genome, we calculated that the passenger pigeon's effective population size throughout the last million years was persistently about 1/10,000 of the 1800's estimated number of individuals, a ratio 1,000-times lower than typically found. This result suggests that the passenger pigeon was not always super abundant but experienced dramatic population fluctuations, resembling those of an "outbreak" species. Ecological niche models supported inference of drastic changes in the extent of its breeding range over the last glacial-interglacial cycle. An estimate of acorn-based carrying capacity during the past 21,000 y showed great year-to-year variations. Based on our results, we hypothesize that ecological conditions that dramatically reduced population size under natural conditions could have interacted with human exploitation in causing the passenger pigeon's rapid demise. Our study illustrates that even species as abundant as the passenger pigeon can be vulnerable to human threats if they are subject to dramatic population fluctuations, and provides a new perspective on the greatest human-caused extinction in recorded history

Journey with Ting-Peng Liang in Pacific Asia Information Systems Field

Our respectful old friend Professor Ting-Peng Liang (in short, TP) whom we loved suddenly passed away on May 20, 2021. But we cannot forget his smile and passion, and his inerasable footprints in PACIS, PAJAIS, and AIS Community. He was the founder of PACIS, founding editor-in-chief of PAJAIS, and past president of AIS to list just a few. He was the pioneer who received the first AIS Fellow and the first LEO Award from Asia Pacific. That is why the leaders of the information systems field organized the first ever special tribute session in PACIS 2021 in memory of TP (https://aisel.aisnet.org/pacis2021/253/

The bracteatus pineapple genome and domestication of clonally propagated crops

Domestication of clonally propagated crops such as pineapple from South America was hypothesized to be a 'one-step operation'. We sequenced the genome of Ananas comosus var. bracteatus CB5 and assembled 513 Mb into 25 chromosomes with 29,412 genes. Comparison of the genomes of CB5, F153 and MD2 elucidated the genomic basis of fiber production, color formation, sugar accumulation and fruit maturation. We also resequenced 89 Ananas genomes. Cultivars 'Smooth Cayenne' and 'Queen' exhibited ancient and recent admixture, while 'Singapore Spanish' supported a one-step operation of domestication. We identified 25 selective sweeps, including a strong sweep containing a pair of tandemly duplicated bromelain inhibitors. Four candidate genes for self-incompatibility were linked in F153, but were not functional in self-compatible CB5. Our findings support the coexistence of sexual recombination and a one-step operation in the domestication of clonally propagated crops. This work guides the exploration of sexual and asexual domestication trajectories in other clonally propagated crops