Personalized Product Evaluation Based on GRA-TOPSIS and Kansei Engineering

With the improvement of human living standards, users’ requirements have changed from function to emotion. Helping users pick out the most suitable product based on their subjective requirements is of great importance for enterprises. This paper proposes a Kansei engineering-based grey relational analysis and techniques for order preference by similarity to ideal solution (KE-GAR-TOPSIS) method to make a subjective user personalized ranking of alternative products. The KE-GRA-TOPSIS method integrates five methods, including Kansei Engineering (KE), analytic hierarchy process (AHP), entropy, game theory, and grey relational analysis-TOPSIS (GRA-TOPSIS). First, an evaluation system is established by KE and AHP. Second, we define a matrix variate—Kansei decision matrix (KDM)—to describe the satisfaction of user requirements. Third, the AHP is used to obtain subjective weight. Next, the entropy method is employed to obtain objective weights by taking the KDM as input. Then the two types of weights are optimized using game theory to obtain the comprehensive weights. Finally, the GRA-TOPSIS method takes the comprehensive weights and the KMD as inputs to rank alternatives. A comparison of the KE-GRA-TOPSIS, KE-TOPSIS, KE-GRA, GRA-TOPSIS, and TOPSIS is conducted to illustrate the unique merits of the KE-GRA-TOPSIS method in Kansei evaluation. Finally, taking the electric drill as an example, we describe the process of the proposed method in detail, which achieves a symmetry between the objectivity of products and subjectivity of users

Perioperative Neurocognitive Disorder: State of the Preclinical Science.

The purpose of this article is to provide a succinct summary of the different experimental approaches that have been used in preclinical postoperative cognitive dysfunction research, and an overview of the knowledge that has accrued. This is not intended to be a comprehensive review, but rather is intended to highlight how the many different approaches have contributed to our understanding of postoperative cognitive dysfunction, and to identify knowledge gaps to be filled by further research. The authors have organized this report by the level of experimental and systems complexity, starting with molecular and cellular approaches, then moving to intact invertebrates and vertebrate animal models. In addition, the authors' goal is to improve the quality and consistency of postoperative cognitive dysfunction and perioperative neurocognitive disorder research by promoting optimal study design, enhanced transparency, and "best practices" in experimental design and reporting to increase the likelihood of corroborating results. Thus, the authors conclude with general guidelines for designing, conducting and reporting perioperative neurocognitive disorder rodent research

Activation of mTORC1 is essential for beta-adrenergic stimulation of adipose browning

A classic metabolic concept posits that insulin promotes energy storage and adipose expansion, while catecholamines stimulate release of adipose energy stores by hydrolysis of triglycerides through beta-adrenergic receptor (betaARs) and protein kinase A (PKA) signaling. Here, we have shown that a key hub in the insulin signaling pathway, activation of p70 ribosomal S6 kinase (S6K1) through mTORC1, is also triggered by PKA activation in both mouse and human adipocytes. Mice with mTORC1 impairment, either through adipocyte-specific deletion of Raptor or pharmacologic rapamycin treatment, were refractory to the well-known betaAR-dependent increase of uncoupling protein UCP1 expression and expansion of beige/brite adipocytes (so-called browning) in white adipose tissue (WAT). Mechanistically, PKA directly phosphorylated mTOR and RAPTOR on unique serine residues, an effect that was independent of insulin/AKT signaling. Abrogation of the PKA site within RAPTOR disrupted betaAR/mTORC1 activation of S6K1 without affecting mTORC1 activation by insulin. Conversely, a phosphomimetic RAPTOR augmented S6K1 activity. Together, these studies reveal a signaling pathway from betaARs and PKA through mTORC1 that is required for adipose browning by catecholamines and provides potential therapeutic strategies to enhance energy expenditure and combat metabolic disease

Nanotwinned Boron Suboxide (B_6O): New Ground State of B_6O

Nanotwinned structures in superhard ceramics rhombohedral boron suboxide (R-B_6O) have been examined using a combination of transmission electron microscopy (TEM) and quantum mechanics (QM). QM predicts negative relative energies to R-B_6O for various twinned R-B_6O (denoted as τ-B_6O, 2τ-B_6O, and 4τ-B_6O), consistent with the recently predicted B_6O structure with Cmcm space group (τ-B_6O) which has an energy 1.1 meV/B_6O lower than R-B_6O. We report here TEM observations of this τ-B_6O structure, confirming the QM predictions. QM studies under pure shear deformation and indentation conditions are used to determine the deformation mechanisms of the new τ-B_6O phase which are compared to R-B_6O and 2τ-B_6O. The lowest stress slip system of τ-B_6O is (010)/⟨001⟩ which transforms τ-B_6O to R-B_6O under pure shear deformation. However, under indentation conditions, the lowest stress slip system changes to (001)/⟨110⟩, leading to icosahedra disintegration and hence amorphous band formation

Nanotwinned Boron Suboxide (B_6O): New Ground State of B_6O

Nanotwinned structures in superhard ceramics rhombohedral boron suboxide (R-B_6O) have been examined using a combination of transmission electron microscopy (TEM) and quantum mechanics (QM). QM predicts negative relative energies to R-B_6O for various twinned R-B_6O (denoted as τ-B_6O, 2τ-B_6O, and 4τ-B_6O), consistent with the recently predicted B_6O structure with Cmcm space group (τ-B_6O) which has an energy 1.1 meV/B_6O lower than R-B_6O. We report here TEM observations of this τ-B_6O structure, confirming the QM predictions. QM studies under pure shear deformation and indentation conditions are used to determine the deformation mechanisms of the new τ-B_6O phase which are compared to R-B_6O and 2τ-B_6O. The lowest stress slip system of τ-B_6O is (010)/⟨001⟩ which transforms τ-B_6O to R-B_6O under pure shear deformation. However, under indentation conditions, the lowest stress slip system changes to (001)/⟨110⟩, leading to icosahedra disintegration and hence amorphous band formation