25,682 research outputs found
Liquid sloshing in elastic containers
Coupled oscillations of elastic container partially filled with incompressible liqui
Tendency of spherically imploding plasma liners formed by merging plasma jets to evolve toward spherical symmetry
Three dimensional hydrodynamic simulations have been performed using smoothed
particle hydrodynamics (SPH) in order to study the effects of discrete jets on
the processes of plasma liner formation, implosion on vacuum, and expansion.
The pressure history of the inner portion of the liner was qualitatively and
quantitatively similar from peak compression through the complete stagnation of
the liner among simulation results from two one dimensional
radiationhydrodynamic codes, 3D SPH with a uniform liner, and 3D SPH with 30
discrete plasma jets. Two dimensional slices of the pressure show that the
discrete jet SPH case evolves towards a profile that is almost
indistinguishable from the SPH case with a uniform liner, showing that
non-uniformities due to discrete jets are smeared out by late stages of the
implosion. Liner formation and implosion on vacuum was also shown to be robust
to Rayleigh-Taylor instability growth. Interparticle mixing for a liner
imploding on vacuum was investigated. The mixing rate was very small until
after peak compression for the 30 jet simulation.Comment: 28 pages, 16 figures, submitted to Physics of Plasmas (2012
Palatable Meal Anticipation in Mice
The ability to sense time and anticipate events is a critical skill in nature. Most efforts to understand the neural and molecular mechanisms of anticipatory behavior in rodents rely on daily restricted food access, which induces a robust increase of locomotor activity in anticipation of daily meal time. Interestingly, rats also show increased activity in anticipation of a daily palatable meal even when they have an ample food supply, suggesting a role for brain reward systems in anticipatory behavior, and providing an alternate model by which to study the neurobiology of anticipation in species, such as mice, that are less well adapted to "stuff and starve" feeding schedules. To extend this model to mice, and exploit molecular genetic resources available for that species, we tested the ability of wild-type mice to anticipate a daily palatable meal. We observed that mice with free access to regular chow and limited access to highly palatable snacks of chocolate or âFruit Crunchiesâ avidly consumed the snack but did not show anticipatory locomotor activity as measured by running wheels or video-based behavioral analysis. However, male mice receiving a snack of high fat chow did show increased food bin entry prior to access time and a modest increase in activity in the two hours preceding the scheduled meal. Interestingly, female mice did not show anticipation of a daily high fat meal but did show increased activity at scheduled mealtime when that meal was withdrawn. These results indicate that anticipation of a scheduled food reward in mice is behavior, diet, and gender specific
MAGIC observations of Mkn 421 in 2008, and related optical/X-ray/TeV MWL study
The HBL-type blazar Markarian 421 is one of the brightest TeV gamma-ray
sources of the Northern sky. From December 2007 until June 2008 it was
intensively observed in the VHE (E>100 GeV) band by the MAGIC gamma-ray
telescope. The source showed intense and prolonged activity during the whole
period. In some nights the integral flux rose up to 3.6 Crab units (E>200 GeV).
Intra-night rapid flux variations were observed. We compared the optical (KVA)
and X-ray (RXTE-ASM, Swift-XRT) data with the MAGIC VHE data, investigating the
correlations between different energy bands.Comment: 4 pages,4figures, Contribution to the 31st ICRC, Lodz, Poland, July
200
Average-Case Optimal Approximate Circular String Matching
Approximate string matching is the problem of finding all factors of a text t
of length n that are at a distance at most k from a pattern x of length m.
Approximate circular string matching is the problem of finding all factors of t
that are at a distance at most k from x or from any of its rotations. In this
article, we present a new algorithm for approximate circular string matching
under the edit distance model with optimal average-case search time O(n(k + log
m)/m). Optimal average-case search time can also be achieved by the algorithms
for multiple approximate string matching (Fredriksson and Navarro, 2004) using
x and its rotations as the set of multiple patterns. Here we reduce the
preprocessing time and space requirements compared to that approach
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Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models.
Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models. In humans with Duchenne muscular dystrophy treated with AOs, low levels of dystrophin have been induced, and modest slowing of disease progression has been observed, highlighting the need for improved efficiency of human skipping drugs. Here, we demonstrate that dantrolene and Rycals S107 and ARM210 potentiate AO-mediated exon skipping of exon 44 or exon 45 in patient-derived myotube cultures with appropriate mutations. Further, dantrolene is shown to boost AO-mediated exon skipping in patient-derived, induced cardiomyocyte cultures. Our findings further validate the ryanodine receptors (RyR) as the likely target responsible for exon skip boosting and demonstrate potential applicability beyond exon 51 skipping. These data provide preclinical support of dantrolene trial as an adjuvant to AO-mediated exon-skipping therapy in humans and identify a novel Rycal, ARM210, for development as a potential exon-skipping booster. Further, they highlight the value of mutation-specific DMD culture models for basic discovery, preclinical drug screening and translation of personalized genetic medicines
STEPS - an approach for human mobility modeling
In this paper we introduce Spatio-TEmporal Parametric Stepping (STEPS) - a simple parametric mobility model which can cover a large spectrum of human mobility patterns. STEPS makes abstraction of spatio-temporal preferences in human mobility by using a power law to rule the nodes movement. Nodes in STEPS have preferential attachment to favorite locations where they spend most of their time. Via simulations, we show that STEPS is able, not only to express the peer to peer properties such as inter-ontact/contact time and to reflect accurately realistic routing performance, but also to express the structural properties of the underlying interaction graph such as small-world phenomenon. Moreover, STEPS is easy to implement, exible to configure and also theoretically tractable
Sharp signature of DDW quantum critical point in the Hall coefficient of the cuprates
We study the behavior of the Hall coefficient, , in a system exhibiting
density-wave (DDW) order in a regime in which the carrier
concentration, , is tuned to approach a quantum critical point at which the
order is destroyed. At the mean-field level, we find that
evinces a sharp signature of the transition. There is a kink in
at the critical value of the carrier concentration, ; as the critical
point is approached from the ordered side, the slope of
diverges. Hall transport experiments in the cuprates, at high magnetic fields
sufficient to destroy superconductivity, should reveal this effect.Comment: 5 pages, 2 eps figure
Time evolution of a quantum many-body system: transition from integrability to ergodicity in thermodynamic limit
Numerical evidence is given for non-ergodic (non-mixing) behavior, exhibiting
ideal transport, of a simple non-integrable many-body quantum system in the
thermodynamic limit, namely kicked model of spinless fermions on a ring.
However, for sufficiently large kick parameters and we recover quantum
ergodicity, and normal transport, which can be described by random matrix
theory.Comment: 4 pages in RevTex (6 figures in PostScript included
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