216 research outputs found
App Review Analytics Of Free Games Listed On Google Play
Smartphones have become popular in recent years; in turn, the number of application developers and publishers has grown rapidly. To understand users’ app preferences, many platforms such as Google Play provide different mechanism that allows users to rank apps. However, more detailed insights on user’s feelings, experiences, critiques, suggestions, or preferences are missing due to a lack of additional written comments. This research attempts to investigate the review analytics of Android games listed on Google Play using a proposed text analytic approach to extract all user reviews from game apps in Chinese. A total of 207,048 reviews of 4,268 free games from February to March 2013 are extracted and analyzed according to various metrics including game type and game attribute. The findings indicate there is high dependency between users’ gender and game type, males and females have differing opinions on game attributes. In particular, users of different game types prefer different game attributes. The results reveal product usage insights, as well as best practices for developers
Artificial Intelligence and Visual Analytics: A Deep-Learning Approach to Analyze Hotel Reviews & Responses
With a growing number of online reviews, consumers often rely on these reviews to make purchase decisions. However, little is known about managerial responses to online hotel reviews. This paper reports on a framework to integrate visual analytics and machine learning techniques to investigate whether hotel managers respond to positive and negative reviews differently and how to use a deep-learning approach to prioritize responses. In this study, forty 4- and 5-star hotels in London with 91,051 reviews and 70,397 responses were collected and analyzed. Visual analyses and machine learning were conducted. The results indicate most hotels (72.5%) showing no preference to respond to positive and negative reviews. Our proposed deep-learning approach outperformed existing algorithms to prioritize responses
The spontaneous emergence of ordered phases in crumpled sheets
X-ray tomography is performed to acquire 3D images of crumpled aluminum
foils. We develop an algorithm to trace out the labyrinthian paths in the three
perpendicular cross sections of the data matrices. The tangent-tangent
correlation function along each path is found to decay exponentially with an
effective persistence length that shortens as the crumpled ball becomes more
compact. In the mean time, we observed ordered domains near the crust, similar
to the lamellae phase mixed by the amorphous portion in lyotropic liquid
crystals. The size and density of these domains grow with further compaction,
and their orientation favors either perpendicular or parallel to the radial
direction. Ordering is also identified near the core with an arbitrary
orientation, exemplary of the spontaneous symmetry breaking
Determination of band alignment in the single layer MoS2/WSe2 heterojunction
The emergence of transition metal dichalcogenides (TMDs) as 2D electronic
materials has stimulated proposals of novel electronic and photonic devices
based on TMD heterostructures. Here we report the determination of band offsets
in TMD heterostructures by using microbeam X-ray photoelectron spectroscopy
({\mu}-XPS) and scanning tunneling microscopy/spectroscopy (STM/S). We
determine a type-II alignment between and
with a valence band offset (VBO) value of 0.83 eV and a conduction band offset
(CBO) of 0.76 eV. First-principles calculations show that in this
heterostructure with dissimilar chalcogen atoms, the electronic structures of
and are well retained in their respective
layers due to a weak interlayer coupling. Moreover, a VBO of 0.94 eV is
obtained from density functional theory (DFT), consistent with the experimental
determination.Comment: ^ These authors contributed equally. *Corresponding author E-mail:
[email protected], [email protected] 20 pages, 4 figures in
main tex
Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence
Focal adhesion kinase (FAK) is a non-receptor kinase that facilitates tumor aggressiveness. The effects of FAK inhibition include arresting proliferation, limiting metastasis, and inhibiting angiogenesis. PF-573228 is an ATP-competitive inhibitor of FAK. Treating lung cancer cells with PF-573228 resulted in FAK inactivation and changes in the expressions of lamin A/C and nuclear deformity. Since lamin A/C downregulation or deficiency was associated with cellular senescence, the senescence-associated β-galactosidase (SA-β-gal) assay was used to investigate whether PF-573228 treatment drove cellular senescence, which showed more SA-β-gal-positive cells in culture. p53 is known to play a pivotal role in mediating the progression of cellular senescence, and the PF-573228-treated lung cancer cells resulted in a higher p53 expression level. Subsequently, the FAK depletion in lung cancer cells was employed to confirm the role of FAK inhibition on cellular senescence. FAK depletion and pharmacological inhibition of lung cancer cells elicited similar patterns of cellular senescence, lamin A/C downregulation, and p53 upregulation, implying that FAK signaling is associated with the expression of p53 and the maintenance of lamin A/C levels to shape regular nuclear morphology and manage anti-senescence. Conversely, FAK inactivation led to p53 upregulation, disorganization of the nuclear matrix, and consequently cellular senescence. Our data suggest a new FAK signaling pathway, in that abolishing FAK signaling can activate the senescence program in cells. Triggering cellular senescence could be a new therapeutic approach to limit tumor growth
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Anti-Neuroinflammatory Effects of the Calcium Channel Blocker Nicardipine on Microglial Cells: Implications for Neuroprotection
Background/Objective Nicardipine is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. However, accumulating evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play important roles in neurodegeneration, and the effect of nicardipine on microglial activation remains unresolved. Methodology/Principal Findings In the present study, using murine BV-2 microglia, we demonstrated that nicardipine significantly inhibits microglia-related neuroinflammatory responses. Treatment with nicardipine inhibited microglial cell migration. Nicardipine also significantly inhibited LPS plus IFN-γ-induced release of nitric oxide (NO), and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, nicardipine also inhibited microglial activation by peptidoglycan, the major component of the Gram-positive bacterium cell wall. Notably, nicardipine also showed significant anti-neuroinflammatory effects on microglial activation in mice in vivo. Conclusion/Significance The present study is the first to report a novel inhibitory role of nicardipine on neuroinflammation and provides a new candidate agent for the development of therapies for inflammation-related neurodegenerative diseases
BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells
For many malignancies, radiation therapy remains the second option only to surgery in terms of its curative potential. However, radiation-induced tumor cell death is limited by a number of factors, including the adverse response of the tumor microenvironment to the treatment and either intrinsic or acquired mechanisms of evasive resistance, and the existence of cancer stem cells (CSCs). In this study, we demonstrated that using different doses of irradiation led to the enrichment of CD133+ Mahlavu cells using flow cytometric method. Subsequently, CD133+ Mahlavu cells enriched by irradiation were characterized for their stemness gene expression, self-renewal, migration/invasion abilities, and radiation resistance. Having established irradiation-enriched CD133+ Mahlavu cells with CSC properties, we evaluated a phytochemical, pterostilbene (PT), found abundantly in blueberries, against irradiation-enriched CSCs. It was shown that PT treatment dose-dependently reduced the enrichment of CD133+ Mahlavu cells upon irradiation; PT treatment also prevented tumor sphere formation, reduced stemness gene expression, and suppressed invasion and migration abilities as well as increasing apoptosis of CD133+ Mahlavu CSCs. Based on our experimental data, pterostilbene could be used to prevent the enrichment of CD133+ hepatoma CSCs and should be considered for future clinical testing as a combined agent for HCC patients
An all-statistics, high-speed algorithm for the analysis of copy number variation in genomes
Detection of copy number variation (CNV) in DNA has recently become an important method for understanding the pathogenesis of cancer. While existing algorithms for extracting CNV from microarray data have worked reasonably well, the trend towards ever larger sample sizes and higher resolution microarrays has vastly increased the challenges they face. Here, we present Segmentation analysis of DNA (SAD), a clustering algorithm constructed with a strategy in which all operational decisions are based on simple and rigorous applications of statistical principles, measurement theory and precise mathematical relations. Compared with existing packages, SAD is simpler in formulation, more user friendly, much faster and less thirsty for memory, offers higher accuracy and supplies quantitative statistics for its predictions. Unique among such algorithms, SAD's running time scales linearly with array size; on a typical modern notebook, it completes high-quality CNV analyses for a 250 thousand-probe array in ∼1 s and a 1.8 million-probe array in ∼8 s
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