2,715 research outputs found
A microangiographic study of the effect of hyperthermia on the rabbit bladder
A model was used to study the effect of hyperthermia on a normal tissue. The model selected was the rabbit bladder and the end point measured was the changes in the micro-vasculature of the bladder wall. It was already demonstrated clinically that hot water bladder infusions produce regression in bladder tumors
Stochastic reaction networks within interacting compartments
Stochastic reaction networks, which are usually modeled as continuous-time
Markov chains on , and simulated via a version of the
"Gillespie algorithm," have proven to be a useful tool for the understanding of
processes, chemical and otherwise, in homogeneous environments. There are
multiple avenues for generalizing away from the assumption that the environment
is homogeneous, with the proper modeling choice dependent upon the context of
the problem being considered. One such generalization was recently introduced
in (Duso and Zechner, PNAS, 2020), where the proposed model includes a varying
number of interacting compartments, or cells, each of which contains an
evolving copy of the stochastic reaction system. The novelty of the model is
that these compartments also interact via the merging of two compartments
(including their contents), the splitting of one compartment into two, and the
appearance and destruction of compartments. In this paper we begin a systematic
exploration of the mathematical properties of this model. We (i) obtain
basic/foundational results pertaining to explosivity, transience, recurrence,
and positive recurrence of the model, (ii) explore a number of examples
demonstrating some possible non-intuitive behaviors of the model, and (iii)
identify the limiting distribution of the model in a special case that
generalizes three formulas from an example in (Duso and Zechner, PNAS, 2020).Comment: 38 page
Small molecule tandem organic photovoltaic cells incorporating an α-NPD optical spacer layer
We report an improvement in power conversion efficiency in a small molecule tandem organic photovoltaic (OPV) device by the optimisation of current balancing of the sub-cells using an optical spacer layer. A co-deposited layer of N,N’-bis(1-naphthyl)-N,N′-diphenyl-1,1’-biphenyl-4,4’-diamine (α-NPD) and molybdenum oxide was used as the optical spacer layer and provided a highly transparent and conductive layer. Optical simulations showed the addition of the optical spacer in a boron subphthalocyanine (SubPc)/C60 based tandem OPV device increased the SubPc absorption in the front sub-cell and resulted in current balancing through the device. Fabricated tandem OPV devices showed similar trends, with the power conversion efficiency increasing from 2.3% to 4.2% with the addition of an optimised optical spacer thickness. External quantum efficiency and total absorption efficiency measurements back up the optical model data which attribute the increased performance to improved SubPc absorption in the front sub-cell, balancing the photocurrents of the two sub-cells
Shaping the formation of university-industry research collaborations: what type of proximity does really matter?
Research collaborations between universities and industry (U-I) are considered to be one important channel of potential localized knowledge spillovers (LKS). These collaborations favour both intended and unintended flows of knowledge and facilitate learning processes between partners from different organizations. Despite the copious literature on LKS, still little is known about the factors driving the formation of U-I research collaborations and, in particular, about the role that geographical proximity plays in the establishment of such relationships. Using collaborative research grants between universities and business firms awarded by the UK Engineering and Physical Sciences Research Council (EPSRC), in this article we disentangle some of the conditions under which different kinds of proximity contribute to the formation of U-I research collaborations, focusing in particular on clustering and technological complementarity among the firms participating in such partnerships
SPEDEN: Reconstructing single particles from their diffraction patterns
Speden is a computer program that reconstructs the electron density of single
particles from their x-ray diffraction patterns, using a single-particle
adaptation of the Holographic Method in crystallography. (Szoke, A., Szoke, H.,
and Somoza, J.R., 1997. Acta Cryst. A53, 291-313.) The method, like its parent,
is unique that it does not rely on ``back'' transformation from the diffraction
pattern into real space and on interpolation within measured data. It is
designed to deal successfully with sparse, irregular, incomplete and noisy
data. It is also designed to use prior information for ensuring sensible
results and for reliable convergence. This article describes the theoretical
basis for the reconstruction algorithm, its implementation and quantitative
results of tests on synthetic and experimentally obtained data. The program
could be used for determining the structure of radiation tolerant samples and,
eventually, of large biological molecular structures without the need for
crystallization.Comment: 12 pages, 10 figure
Mesoscale observations of Joule heating near an auroral arc and ion-neutral collision frequency in the polar cap E region
We report on the first mesoscale combined ionospheric and thermospheric observations, partly in the vicinity of an auroral arc, from Svalbard in the polar cap on 2 February 2010. The EISCAT Svalbard radar employed a novel scanning mode in order to obtain F and E region ion flows over an annular region centered on the radar. Simultaneously, a colocated Scanning Doppler Imager observed the E region neutral winds and temperatures around 110 km altitude using the 557.7 nm auroral optical emission. Combining the ion and neutral data permits the E region Joule heating to be estimated with an azimuthal spatial resolution of ∼64 km at a radius of ∼163 km from the radar. The spatial distribution of Joule heating shows significant mesoscale variation. The ion-neutral collision frequency is measured in the E region by combining all the data over the entire field of view with only weak aurora present. The estimated ion-neutral collision frequency at ∼113 km altitude is in good agreement with the MSIS atmospheric model
Phasing diffuse scattering. Application of the SIR2002 algorithm to the non-crystallographic phase problem
A new phasing algorithm has been used to determine the phases of diffuse
elastic X-ray scattering from a non-periodic array of gold balls of 50 nm
diameter. Two-dimensional real-space images, showing the charge-density
distribution of the balls, have been reconstructed at 50 nm resolution from
transmission diffraction patterns recorded at 550 eV energy. The reconstructed
image fits well with scanning electron microscope (SEM) image of the same
sample. The algorithm, which uses only the density modification portion of the
SIR2002 program, is compared with the results obtained via the
Gerchberg-Saxton-Fienup HIO algorithm. In this way the relationship between
density modification in crystallography and the HiO algorithm used in signal
and image processing is elucidated.Comment: 7 pages, 12 figure
A representative sample of Be stars III: H band spectroscopy
We present H band (1.53 - 1.69 micron) spectra of 57 isolated Be stars of
spectral types O9-B9 and luminosity classes III,IV & V. The HI Brackett (n-4)
series is seen in emission from Br 11-18, and FeII emission is also apparent
for a subset of those stars with HI emission. No emission from species with a
higher excitation temperature, such as He II or CIII is seen, and no forbidden
line emission is present. A subset of 12 stars show no evidence for emission
from any species; these stars appear indistinguishable from normal B stars of a
comparable spectral type. In general the line ratios constructed from the
transitions in the range Br 11-18 do not fit case B recombination theory
particularly well. Strong correlations between the line ratios with Br-gamma
and spectral type are found. These results most likely represent systematic
variations in the temperature and ionization of the circumstellar disc with
spectral type. Weak correlations between the line widths and projected
rotational velocity of the stars are observed; however no systematic trend for
increasing line width through the Brackett series is observed.Comment: accepted for publication in A&A (this version correctly formatted
Use of extended and prepared reference objects in experimental Fourier transform X-ray holography
The use of one or more gold nanoballs as reference objects for Fourier
Transform holography (FTH) is analysed using experimental soft X-ray
diffraction from objects consisting of separated clusters of these balls. The
holograms are deconvoluted against ball reference objects to invert to images,
in combination with a Wiener filter to control noise. A resolution of ~30nm,
smaller than one ball, is obtained even if a large cluster of balls is used as
the reference, giving the best resolution yet obtained by X-ray FTH. Methods of
dealing with missing data due to a beamstop are discussed. Practical prepared
objects which satisfy the FTH condition are suggested, and methods of forming
them described.Comment: 7 pages, 2 figures, submitted to Applied Physics Letter
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