Office economies for non-standard operations

Thesis (M.B.A.)--Boston Universit

Around the world business process education and research has taken off, except in the USA. Why?

Today’s leading organizations are investing millions of dollars in Business Process Management (BPM) related services and software products. The BPM area is expected to be a $26B industry next year and grow by at least 12% for the foreseeable future. However, the bulk of BPM research and university-level course offerings are not in the USA. Why is there so little BPM education and research in the USA? Why are top recruiting firms for this area in the USA going to Europe or to Ops Management or Industrial Engineering? Are we laggards in the USA, or do we know something the rest of the world fails to see? These questions and the other questions and related topics will be addressed in this panel session.(undefined

Changing Lifeways along the Guadalupe Basin in South Texas: The Results of National Register Testing of a Stratified Multicomponent Prehistoric Site, 41DW277, DeWitt County, Texas

AmaTerra Environmental (formerly Ecological Communications Corporation [EComm]) conducted archeological National Register eligibility testing at Site 41DW277 in December 2009. The site is located in the proposed right-of-way (ROW) for a new bridge along US 183 over the Guadalupe River, DeWitt County, Texas. Site 41DW277 was documented in 2009 by James Abbott and Allen Bettis of the Texas Department of Transportation (TxDOT) and at the time of survey it was thought to be potentially eligible for listing on the National Register of Historic Places (NRHP) or as a State Archeological Landmark (SAL). Due to expected impacts resulting from the proposed bridge construction, testing was recommended to determine NRHP/SAL eligibility. TxDOT hired AmaTerra to complete the work under Texas Antiquities Permit 5460. Testing consisted of excavation of five gradall trenches and 32 test units. AmaTerra found that the site consists of three stratified prehistoric components extending from 1–2 meters in depth and ranging from 2,800 years to 5,200 years BP in age. Three features were documented and artifacts recovered included lithic debris and tools, mussel shell, snail shell, a small amount of bone, and some modern household debris (from the top levels of the units). Burned rock was observed and documented but not collected. An interim report was submitted in January 2010 recommending that the upper components of the site are not eligible for NRHP/SAL listing but that lowest and oldest component is eligible. However, the report also recommended that no further work was needed since the lowest component was not within the area of potential effect (APE) for the bridge replacement. The Texas Historical Commission concurred with this recommendation in February 2010. This report documents the results of the testing and analysis for Site 41DW277. Records and artifacts generated during this project will be curated at the Center for Archaeological Studies at Texas State University

A sensitivity study of parameters used in shrinkage and creep prediction models

Over the last 15 years, there have been numerous models put forward for the prediction of the time-dependent behaviour of concrete and consequently concrete structures. The development of these models from a number of different sources has meant that the engineer now has a choice to make when undertaking creep and shrinkage prediction and it is difficult to know which is best suited for this purpose. Some are considerably more complex than others requiring greater amounts of input focusing on material data, concrete properties, environmental conditions, specimen geometry and loading conditions. The study reported here focuses on the sensitivity to change, in both the short term and over time, of the individual parameters that comprise the input and whether one model is more appropriate in any given situation. It has been found that for each model certain parameters are more sensitive than others. It is suggested that for any given model, the parameters that do not reflect the expected behaviour when changed counterbalance each other, cancelling out any errors. This further suggests that when deciding on which model to use when predicting shrinkage and creep strains it is prudent to look at the specific conditions that prevail, assess the relevant input parameters for which data are available, assess the sensitivity level of each of these parameters and then make a decision as to the most appropriate model to use

What are the odds? Identifying factors related to competitive success in powerlifting

Background: The ability for athletes to gain a competitive advantage over their opponents is well recognised. At times, this advantage may be considered a marginal gain. However, in the context of competition, marginal advantages may be the difference between winning and losing. This investigation explores how competition factors influence the odds of competitive success (i.e. winning) in powerlifting (PL) to assist athletes and coaches in achieving a competitive advantage. Methods: A cross-sectional, retrospective analysis of competition data from raw/classic, Australian powerlifting competitions 2010–2019 was conducted. Data included 10,599 competition entries (males: n = 6567 [62%], females: n = 4032 [38%]). Independent t-tests were used to compare continuous data between sexes or winners and non-winners at an event. Cohen’s d and the 95% confidence interval (d [95% CI]) were calculated. Univariate odds of winning an event based on independent variables (age [irrespective of category], sex, body weight and weight of first lift attempt [regardless of success]), were assessed by separate simple logistic regression. Results: When compared to males, the odds of winning for females were 50% greater (OR [95% CI] 1.500 [1.384, 1.625]; P \u3c 0.001). Athletes who had larger first lift attempts (Squat: + 7.0 kg P \u3c 0.001, Bench Press: + 3.2 kg P \u3c 0.001, and Deadlift: + 6.1 kg P \u3c 0.001and competed for a longer period (winners: 401 vs non-winners: 304 days, P \u3c 0.001) had an increased likelihood winning. Age was associated with increased odds of success for males (OR [95% CI] 1.014 [1.009, 1.019], P \u3c 0.001) per additional year of age for males, but not females (P = 0.509). Conclusions: Multiple factors appear to contribute to the likelihood of winning a PL competition. These results may help coaches to develop competition and training strategies that optimise athletes’ likelihood of competitive success in PL

Powerlifting participation and engagement across all ages: A retrospective, longitudinal, population analysis with comparison to community strength norms

Background: In Australia, one-third of people ≥ 15 years perform regular resistance training and 90% of those do not meet current health guidelines. All age groups should engage in regular resistance exercise, to maintain strength and function. Objectives: To identify trends in powerlifting competition participation in Australia by sex and age group from 1968 to 2022, and to compare the strength of powerlifting competitors to population age- and sex-based normative values. Method: The number of unique participants and total competition entries for each year were analysed using Australian powerlifting competition data. Subdomains of age and sex were investigated, and mean ± SD, frequency, range, and trend analyses reported. United Nations age classifications were used to identify age trends. Comparisons to population strength norms were explored descriptively. Results: We included 21,514 individual competitors from 1942 powerlifting competitions between 1968 and 2022. Exponential growth was seen in competition entries from 115 in 1981, to 759 in 1994, 1014 in 2011, and to 6803 in 2022, (R2= 0.86). At first participation 18–25-year olds (51.1%) followed by ≥ 36 years (16%) were most represented. Strength comparison to available population norms demonstrates superior upper- (bench press [most competitors above 70th percentile) and lower-body (squat [majority rated ‘excellent’) strength. Conclusions: Superior strength levels of powerlifters further the evidence base for this sport as an effective way to develop muscular strength, with low injury. We advocate for public health promotion and additional support for powerlifting as an underutilised community health tool

A call for transparent reporting to optimize the predictive value of preclinical research

The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress

Polyphenols Sensitization Potentiates Susceptibility of MCF-7 and MDA MB-231 Cells to Centchroman

Polyphenols as “sensitizers” together with cytotoxic drugs as “inducers” cooperate to trigger apoptosis in various cancer cells. Hence, their combination having similar mode of mechanism may be a novel approach to enhance the efficacy of inducers. Additionally, this will also enable to achieve the physiological concentrations facilitating significant increase in the activity at concentrations which the compound can individually provide. Here we propose that polyphenols (Resveratrol (RES) and Curcumin (CUR)) pre-treatment may sensitize MCF-7/MDA MB-231 (Human Breast Cancer Cells, HBCCs) to Centchroman (CC, antineoplastic agent). 6 h pre-treated cells with 10 µM RES/CUR and 100 µM RES/30 µM CUR doses, followed by 10 µM CC for 18 h were investigated for Ser-167 ER-phosphorylation, cell cycle arrest, redox homeostasis, stress activated protein kinase (SAPKs: JNK and p38 MAPK) pathways and downstream apoptosis effectors. Low dose RES/CUR enhances the CC action through ROS mediated JNK/p38 as well as mitochondrial pathway in MCF-7 cells. However, RES/CUR sensitization enhanced apoptosis in p53 mutant MDA MB-231 cells without/with involvement of ROS mediated JNK/p38 adjunct to Caspase-9. Contrarily, through high dose sensitization in CC treated cells, the parameters remained unaltered as in polyphenols alone. We conclude that differential sensitization of HBCCs with low dose polyphenol augments apoptotic efficacy of CC. This may offer a novel approach to achieve enhanced action of CC with concomitant reduction of side effects enabling improved management of hormone-dependent breast cancer