The Polarization of American Politics

Elected officials in the United States appear to represent relatively extreme support coalitions rather than the interests of middle-of-the-road voters. This contention is supported by analysis of variance of liberal-conservative positions in the United States Senate from 1959 to 1980. Within both the Democratic and the Republican parties, there is considerable variation in liberal-conservative positions, but two senators from the same state and party tend to be very similar. In contrast, senators from the same state but from different parties are highly dissimilar, suggesting that each party represents an extreme support coalition in the state. Moreover, the distribution of senators is now consistent with the hypothesis that, in the long run, both parties have an equal chance of winning any seat in the Senate. This result suggests that there is now competition between equally balanced but extreme support coalitions throughout most of the United States

A Spatial Model for Legislative Roll Call Analysis

A general nonlinear logit model is used to analyze political choice data. The model assumes probabilistic voting based on a spatial utility function. The parameters of the utility function and the spatial coordinates of the choices and the choosers can all be estimated on the basis of observed choices. Ordinary Guttman scaling is a degenerate case of this model. Estimation of the model is implemented in the NOMINATE program for one dimensional analysis of two alternative choices with no nonvoting. The robustness and face validity of the program outputs are evaluated on the basis of roll call voting data for the U.S. House and Senate. Extensive Monte Carlo studies are also presented. Substantive applications using the results for the Senate are briefly illustrated

Exercise-induced pulmonary hemorrhage: where are we now?

Citation: Poole, D. C., & Erickson, H. H. (2016). Exercise-induced pulmonary hemorrhage: where are we now? Veterinary Medicine-Research and Reports, 7, 133-148. https://doi.org/10.2147/vmrr.s120421As the Thoroughbreds race for the final stretch, 44 hooves flash and thunder creating a cacophony of tortured air and turf. Orchestrated by selective breeding for physiology and biomechanics, expressed as speed, the millennia-old symphony of man and beast reaches its climax. At nearly 73 kilometers per hour (45 mph) over half a ton of flesh and bone dwarfs its limpet-like jockey as, eyes wild and nostrils flaring, their necks stretch for glory. Beneath each resplendent livery-adorned, latherin-splattered coat hides a monstrous heart trilling at 4 beats per second, and each minute, driving over 400 L (105 gallons) of oxygen-rich blood from lungs to muscles. Matching breath to stride frequency, those lungs will inhale 16 L (4 gallons) of air each stride moving >1,000 L/min in and out of each nostril - and yet failing. Engorged with blood and stretched to breaking point, those lungs can no longer redden the arterial blood but leave it dusky and cyanotic. Their exquisitely thin blood-gas barrier, a mere 10.5 mu m thick (1/50,000 of an inch), ruptures, and red cells invade the lungs. After the race is won and lost, long after the frenetic crowd has quieted and gone, that blood will clog and inflame the airways. For a few horses, those who bleed extensively, it will overflow their lungs and spray from their nostrils incarnadining the walls of their stall: a horrifically poignant canvas that strikes at horse racing's very core. That exercise-induced pulmonary hemorrhage (EIPH) occurs is a medical and physiological reality. That every reasonable exigency is not taken to reduce/prevent it would be a travesty. This review is not intended to provide an exhaustive coverage of EIPH for which the reader is referred to recent reviews, rather, after a brief reminder of its physiologic and pathologic bases, focus is brought on the latest developments in EIPH discovery as this informs state-of-the-art knowledge, the implementation of that knowledge and recommendations for future research and treatment

The Effectiveness of Food Insecurity Screening in Pediatric Primary Care

Background: Food insecure children are at increased risk for medical and developmental problems. Effective screening and intervention are needed. Methods: Our purpose was to (1) evaluate the validity and stability of a single item food insecurity (FI) screen. (2) Assess whether use may lead to decreased FI. Part of a larger cluster randomized controlled trial, pediatric residents were assigned to SEEK or control groups. A single FI question (part of a larger questionnaire) was used on SEEK days. SEEK residents learned to screen, assess, and address FI. A subset of SEEK and control clinic parents was recruited for the evaluation. Parents completed the USDA Food Security Scale (“gold standard”), upon recruitment and 6-months later. Validity, positive and negative predictive values (PPV, NPV) was calculated. The proportion of screened families with initial and subsequent FI was measured. Screening effectiveness was evaluated by comparing SEEK and control screening rates and receipt of Supplemental Nutrition Assistance Program (SNAP) benefits between initial and 6-month assessments. Results: FI screen stability indicated substantial agreement (Cohen's kappa =0.69). Sensitivity and specificity was 59% and 87%, respectively. The PPV was 70%; NPV was 81%. SEEK families had a larger increase in screening rates than control families (24% vs. 4.1%, p<0.01). SEEK families were more likely to maintain SNAP enrollment (97% vs. 81%, p=0.05). FI rates remained stable at approximately 30% for both groups. Conclusions: A single question screen can identify many families with FI, and may help maintain food program enrollment. Screening may not be adequate to alleviate FI

Are Library Users Also Computer Users? A Survey of Faculty and Implications for Services.

Describes the results of a survey of faculty members at Western Michigan University which was conducted to explore the relationship between faculty use of university libraries and faculty use of computers. Implications for libraries are discussed, including computer databases, faculty assistance, collaboration with computing staff, and marketing of electronic services

Recovering a Basic Space from Issue Scales in<i>R</i>

Basicspace is an R package that conducts Aldrich-McKelvey and Blackbox scaling to recover estimates of the underlying latent dimensions of issue scale data. We illustrate several applications of the package to survey data commonly used in the social sciences. Monte Carlo tests demonstrate that the procedure can recover latent dimensions and reproduce the matrix of responses at moderate levels of error and missing data

CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress

The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export, gene expression, metabolic perturbations, intracellular pH homeostasis, and tolerance to nitric oxide (NO). Loss of CydDC was found to decrease extracytoplasmic thiol levels, whereas overexpression diminished the cytoplasmic thiol content. Transcriptomic analysis revealed a dramatic up-regulation of protein chaperones, protein degradation (via phenylpropionate/phenylacetate catabolism), ?-oxidation of fatty acids, and genes involved in nitrate/nitrite reduction. 1H NMR metabolomics revealed elevated methionine and betaine and diminished acetate and NAD+ in cydD cells, which was consistent with the transcriptomics-based metabolic model. The growth rate and ?pH, however, were unaffected, although the cydD strain did exhibit sensitivity to the NO-releasing compound NOC-12. These observations are consistent with the hypothesis that the loss of CydDC-mediated reductant export promotes protein misfolding, adaptations to energy metabolism, and sensitivity to NO. The addition of both glutathione and cysteine to the medium was found to complement the loss of bd -type cytochrome synthesis in a cydD strain (a key component of the pleiotropic cydDC phenotype), providing the first direct evidence that CydDC substrates are able to restore the correct assembly of this respiratory oxidase. These data provide an insight into the metabolic flexibility of E. coli , highlight the importance of bacterial redox homeostasis during nitrosative stress, and report for the first time the ability of periplasmic low molecular weight thiols to restore haem incorporation into a cytochrome complex

A Spatial Model for Legislative Roll Call Analysis

A general nonlinear logit model is used to analyze political choice data. The model assumes probabilistic voting based on a spatial utility function. The parameters of the utility function and the spatial coordinates of the choices and the choosers can all be estimated on the basis of observed choices. Ordinary Guttman scaling is a degenerate case of this model. Estimation of the model is implemented in the NOMINATE program for one dimensional analysis of two alternative choices with no nonvoting. The robustness and face validity of the program outputs are evaluated on the basis of roll call voting data for the U.S. House and Senate. Extensive Monte Carlo studies are also presented. Substantive applications using the results for the Senate are briefly illustrated

The Polarization of American Politics

Elected officials in the United States appear to represent relatively extreme support coalitions rather than the interests of middle-of-the-road voters. This contention is supported by analysis of variance of liberal-conservative positions in the United States Senate from 1959 to 1980. Within both the Democratic and the Republican parties, there is considerable variation in liberal-conservative positions, but two senators from the same state and party tend to be very similar. In contrast, two senators from the same state but from different parties are highly dissimilar, suggesting that each party represents an extreme support coalition in the state. Moreover, the distribution of senators is now consistent with the hypothesis that, in the long run, both parties are equally likely to win any seat in the Senate. This result suggests that there is now competition between equally balanced but extreme support coalitions throughout most of the United States