7,473 research outputs found
Molecular Model of the Contractile Ring
We present a model for the actin contractile ring of adherent animal cells.
The model suggests that the actin concentration within the ring and
consequently the power that the ring exerts both increase during contraction.
We demonstrate the crucial role of actin polymerization and depolymerization
throughout cytokinesis, and the dominance of viscous dissipation in the
dynamics. The physical origin of two phases in cytokinesis dynamics ("biphasic
cytokinesis") follows from a limitation on the actin density. The model is
consistent with a wide range of measurements of the midzone of dividing animal
cells.Comment: PACS numbers: 87.16.Ka, 87.16.Ac
http://www.ncbi.nlm.nih.gov/pubmed/16197254
http://www.weizmann.ac.il/complex/tlusty/papers/PhysRevLett2005.pd
Estimating Infection Risks and the Global Burden of Diarrheal Disease Attributable to Intermittent Water Supply Using QMRA.
: Intermittent water supply (IWS) is prevalent throughout low and middle-income countries. IWS is associated with increased microbial contamination and potentially elevated risk of waterborne illness. We used existing data sets to estimate the population exposed to IWS, assess the probability of infection using quantitative microbial risk assessment, and calculate the subsequent burden of diarrheal disease attributable to consuming fecally contaminated tap water from an IWS. We used reference pathogens Campylobacter, Cryptosporidium, and rotavirus as conservative risk proxies for infections via bacteria, protozoa, and viruses, respectively. Results indicate that the median daily risk of infection is an estimated 1 in 23 500 for Campylobacter, 1 in 5 050 000 for Cryptosporidium, and 1 in 118 000 for rotavirus. Based on these risks, IWS may account for 17.2 million infections causing 4.52 million cases of diarrhea, 109 000 diarrheal DALYs, and 1560 deaths each year. The burden of diarrheal disease associated with IWS likely exceeds the WHO health-based normative guideline for drinking water of 10-6 DALYs per person per year. Our results underscore the importance water safety management in water supplies and the potential benefits of point-of-use treatment to mitigate risks.<br/
Performance, Control, and Simulation of the Affordable Guided Airdrop System
This paper addresses the development of an autonomous
guidance, navigation and control system for a flat
solid circular parachute. This effort is a part of the Affordable
Guided Airdrop System (AGAS) that integrates
a low-cost guidance and control system into
fielded cargo air delivery systems. The paper describes
the AGAS concept, its architecture and components. It
then reviews the literature on circular parachute modeling
and introduces a simplified model of a parachute.
This model is used to develop and evaluate the performance
of a modified bang-bang control system to
steer the AGAS along a pre-specified trajectory towards
a desired landing point. The synthesis of the optimal
control strategy based on Pontryagin's principle of optimality
is also presented. The paper is intended to be a
summary of the current state of AGAS development.
The paper ends with the summary of the future plans in
this area
Enhanced reaction kinetics in biological cells
The cell cytoskeleton is a striking example of "active" medium driven
out-of-equilibrium by ATP hydrolysis. Such activity has been shown recently to
have a spectacular impact on the mechanical and rheological properties of the
cellular medium, as well as on its transport properties : a generic tracer
particle freely diffuses as in a standard equilibrium medium, but also
intermittently binds with random interaction times to motor proteins, which
perform active ballistic excursions along cytoskeletal filaments. Here, we
propose for the first time an analytical model of transport limited reactions
in active media, and show quantitatively how active transport can enhance
reactivity for large enough tracers like vesicles. We derive analytically the
average interaction time with motor proteins which optimizes the reaction rate,
and reveal remarkable universal features of the optimal configuration. We
discuss why active transport may be beneficial in various biological examples:
cell cytoskeleton, membranes and lamellipodia, and tubular structures like
axons.Comment: 10 pages, 2 figure
String breaking by dynamical fermions in three-dimensional lattice QCD
The first observation is made of hadronic string breaking due to dynamical
fermions in zero temperature lattice QCD. The simulations are done for SU(2)
color in three dimensions, with two flavors of staggered fermions. The results
have clear implications for the large scale simulations that are being done to
search (so far, without success) for string breaking in four-dimensional QCD.
In particular, string breaking is readily observed using only Wilson loops to
excite a static quark-antiquark pair. Improved actions on coarse lattices are
used, providing an extremely efficient means to access the quark separations
and propagation times at which string breaking occurs.Comment: Revised version to appear in Physical Review D, has additional
discussion of the results, additional references, modified title, larger
figure
Molecular motor that never steps backwards
We investigate the dynamics of a classical particle in a one-dimensional
two-wave potential composed of two periodic potentials, that are
time-independent and of the same amplitude and periodicity. One of the periodic
potentials is externally driven and performs a translational motion with
respect to the other. It is shown that if one of the potentials is of the
ratchet type, translation of the potential in a given direction leads to motion
of the particle in the same direction, whereas translation in the opposite
direction leaves the particle localized at its original location. Moreover,
even if the translation is random, but still has a finite velocity, an
efficient directed transport of the particle occurs.Comment: 4 pages, 5 figures, Phys. Rev. Lett. (in print
A Hot Uranus Orbiting the Super Metal-rich Star HD77338 and the Metallicity - Mass Connection
We announce the discovery of a low-mass planet orbiting the super metal-rich
K0V star HD77338 as part of our on-going Calan-Hertfordshire Extrasolar Planet
Search. The best fit planet solution has an orbital period of 5.7361\pm0.0015
days and with a radial velocity semi-amplitude of only 5.96\pm1.74 m/s, we find
a minimum mass of 15.9+4.7-5.3 Me. The best fit eccentricity from this solution
is 0.09+0.25-0.09, and we find agreement for this data set using a Bayesian
analysis and a periodogram analysis. We measure a metallicity for the star of
+0.35\pm0.06 dex, whereas another recent work (Trevisan et al. 2011) finds
+0.47\pm0.05 dex. Thus HD77338b is one of the most metal-rich planet host stars
known and the most metal-rich star hosting a sub-Neptune mass planet. We
searched for a transit signature of HD77338b but none was detected. We also
highlight an emerging trend where metallicity and mass seem to correlate at
very low masses, a discovery that would be in agreement with the core accretion
model of planet formation. The trend appears to show that for Neptune-mass
planets and below, higher masses are preferred when the host star is more
metal-rich. Also a lower boundary is apparent in the super metal-rich regime
where there are no very low-mass planets yet discovered in comparison to the
sub-solar metallicity regime. A Monte Carlo analysis shows that this, low-mass
planet desert, is statistically significant with the current sample of 36
planets at around the 4.5\sigma\ level. In addition, results from Kepler
strengthen the claim for this paucity of the lowest-mass planets in super
metal-rich systems. Finally, this discovery adds to the growing population of
low-mass planets around low-mass and metal-rich stars and shows that very
low-mass planets can now be discovered with a relatively small number of data
points using stable instrumentation.Comment: 25 pages, 15 figures, 5 tables, accepted for publication in Ap
Basins of attraction on random topography
We investigate the consequences of fluid flowing on a continuous surface upon
the geometric and statistical distribution of the flow. We find that the
ability of a surface to collect water by its mere geometrical shape is
proportional to the curvature of the contour line divided by the local slope.
Consequently, rivers tend to lie in locations of high curvature and flat
slopes. Gaussian surfaces are introduced as a model of random topography. For
Gaussian surfaces the relation between convergence and slope is obtained
analytically. The convergence of flow lines correlates positively with drainage
area, so that lower slopes are associated with larger basins. As a consequence,
we explain the observed relation between the local slope of a landscape and the
area of the drainage basin geometrically. To some extent, the slope-area
relation comes about not because of fluvial erosion of the landscape, but
because of the way rivers choose their path. Our results are supported by
numerically generated surfaces as well as by real landscapes
Phase transitions and correlations in the bosonic pair contact process with diffusion: Exact results
The variance of the local density of the pair contact process with diffusion
(PCPD) is investigated in a bosonic description. At the critical point of the
absorbing phase transition (where the average particle number remains constant)
it is shown that for lattice dimension d>2 the variance exhibits a phase
transition: For high enough diffusion constants, it asymptotically approaches a
finite value, while for low diffusion constants the variance diverges
exponentially in time. This behavior appears also in the density correlation
function, implying that the correlation time is negative. Yet one has dynamical
scaling with a dynamical exponent calculated to be z=2.Comment: 20 pages, 5 figure
- …