27,203 research outputs found
Skeletal stressing method and apparatus Patent
Method and apparatus for applying compressional forces to skeletal structure of subject to simulate force during ambulatory condition
Weight simulator
Device applies compressive force to bone to minimize loss of bone calcium during weightlessness or bedrest. Force is applied through weights, or hydraulic, pneumatic or electrically actuated devices. Device is lightweight and easy to maintain and operate
Programmable physiological infusion
A programmable physiological infusion device and method are provided wherein a program source, such as a paper tape, is used to actuate an infusion pump in accordance with a desired program. The system is particularly applicable for dispensing calcium in a variety of waveforms
Programmed physiological infusion system
Infusion system delivers incremental volumes from a reservoir with a piston pump at a rate that varies in time and follows the envelope of a preprogrammed curve
Kinematic study of flight telerobotic servicer configuration issues
Several factors, such as body size and shape, and the number of arms and their placement, will influence how well the Flight Telerobotic Servicer (FTS) is suited to its potential duties for the Space Station Program. In order to examine the implications of these configuration options, eight specific 2, 3, and 4 armed FTS configuration were simulated and used to perform a Space Station Orbital Replacement Unit (ORU) exchange. The strengths and weaknesses of each configuration were evaluated. Although most of the configurations examined were able to perform the exchange, several of the 3 and 4 arm configurations had operational advantages. The results obtained form these simulations are specific to the assumptions associated with the ORU exchange scenario examined. However, they do illustrate the general interrelationships and sensitivities which need to be understood
Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis.
11 p.-4 fig.-1 tab.Background: Increased circulating levels of endoglin+ endothelial microparticles (EMPs) have been identified in several cardiovascular disorders, related to severity. Endoglin is an auxilary receptor for transforming growth factor β (TGF-β) important in the regulation of vascular structure.Results: We quantified the number of microparticles in plasma of six patients with chronic thromboembolic pulmonary hypertension (CTEPH) and age- and sex-matched pulmonary embolic (PE) and healthy controls and investigated the role of microparticle endoglin in the regulation of pulmonary endothelial function in vitro. Results show significantly increased levels of endoglin+ EMPs in CTEPH plasma, compared to healthy and disease controls. Co-culture of human pulmonary endothelial cells with CTEPH microparticles increased intracellular levels of endoglin and enhanced
TGF-β-induced angiogenesis and Smad1,5,8 phosphorylation in cells, without affecting BMPRII expression. In an in vitro model, we generated endothelium-derived MPs with enforced membrane localization of endoglin. Co-culture of these MPs with endothelial cells increased cellular endoglin content, improved cell survival and stimulated
angiogenesis in a manner similar to the effects induced by overexpressed protein.Conclusions: Increased generation of endoglin+ EMPs in CTEPH is likely to represent a protective mechanism supporting endothelial cell survival and angiogenesis, set to counteract the effects of vascular occlusion and endothelial damage.This research was supported by a project grant (PG 11/13/28765) from the British Heart Foundation and by grants from Ministerio de Economia y Competitividad of Spain (SAF2013-43421-R to CB)Peer reviewe
Transport of Molecular Motor Dimers in Burnt-Bridge Models
Dynamics of molecular motor dimers, consisting of rigidly bound particles
that move along two parallel lattices and interact with underlying molecular
tracks, is investigated theoretically by analyzing discrete-state stochastic
continuous-time burnt-bridge models. In these models the motion of molecular
motors is viewed as a random walk along the lattices with periodically
distributed weak links (bridges). When the particle crosses the weak link it
can be destroyed with a probability , driving the molecular motor motion in
one direction. Dynamic properties and effective generated forces of dimer
molecular motors are calculated exactly as a function of a concentration of
bridges and burning probability and compared with properties of the
monomer motors. It is found that the ratio of the velocities of the dimer and
the monomer can never exceed 2, while the dispersions of the dimer and the
monomer are not very different. The relative effective generated force of the
dimer (as compared to the monomer) also cannot be larger than 2 for most sets
of parameters. However, a very large force can be produced by the dimer in the
special case of for non-zero shift between the lattices. Our
calculations do not show the significant increase in the force generated by
collagenase motor proteins in real biological systems as predicted by previous
computational studies. The observed behavior of dimer molecular motors is
discussed by considering in detail the particle dynamics near burnt bridges.Comment: 21 pages and 11 figure
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