Facile syntheses of building blocks for the construction of phosphotyrosine mimetics

The copper-catalysed zinc phosphonate chemistry described by Yokomatsu and Shibuya can be used to enter the classical organometallic coupling repertoire via Stille and Suzuki–Miyaura couplings. 1,4-Diiodobenzene underwent coupling with the organozinc reagent derived from diethyl bromodifluoromethylphosphonate with copper(I) catalysis to afford diethyl (4-iodophenyl)difluoromethylphosphonate. Higher yielding couplings were run with (4-trifluoromethylsulfonyloxy)- and (4-nonafluorobutylsulfonyloxy)-iodobenzenes. The iodide and the triflate coupled under palladium-catalysed conditions with a range of stannanes and boronic acids in moderate to excellent yields. Shibuya–Yokomatsu couplings were also successful with more functionalised iodoarenes and heteroarenes presenting the important phosphate mimic on a range of scaffolds

The intersection of race, sexual orientation, socioeconomic status, trans identity, and mental health outcomes

The present study examined patterns in trans individuals’ multiple identities and mental health outcomes. Cluster 1 (socioeconomic and racial privilege; n = 239) was characterized by individuals who identified as trans women or cross-dressers, lesbian, bisexual, or questioning; had associates degrees; reported household incomes of $60,000 or more a year; and were non-Latino White. Cluster 2 (educational privilege; n = 191) was characterized by individuals who identified as trans men or genderqueer, gay, or queer; had a bachelor’s degree; reported household incomes of$10,000 or less a year; and were people of color. There was a pattern of individuals in Cluster 1 who identified with two privileged identities (identifying as White and having higher household incomes), whereas individuals in Cluster 2 identified only formal education as a privilege. Individuals in Cluster 2 reported statistically significant levels of anxiety. Implications of these results for future research and clinical practice are examined.Accepted manuscrip

Core Design

This article examines the role of 'Core Design' within the first year studies of the Design and Technology Degree Course. Core is followed by students on both 3 year degree and the 4 year 'with education' course. It reveals the debt owed to a variety of 'Core' studies in design whilst indicating the contemporary requirement for a 'newfoundation' within the degree of Design and Technology at Loughborough. This requirement is highlighted through case studies of students and their work within 'core'

The Role of GIS to Enable Public-Sector Decision Making Under Conditions of Uncertainty

Uncertainty is inherent in environmental planning and decision making. For example, water managers in arid regions are attuned to the uncertainty of water supply due to prolonged periods of drought. To contend with multiple sources and forms of uncertainty, resource managers implement strategies and tools to aid in the exploration and interpretation of data and scenarios. Various GIS capabilities, such as statistical analysis, modeling and visualization are available to decision makers who face the challenge of making decisions under conditions of deep uncertainty. While significant research has lead to the inclusion and representation of uncertainty in GIS, existing GIS literature does not address how decision makers implement and utilize GIS as an assistive technology to contend with deep uncertainty. We address this gap through a case study of water managers in the Phoenix Metropolitan Area, examining how they engage with GIS in making decisions and coping with uncertainty. Findings of a qualitative analysis of water mangers reveal the need to distinguish between implicit and explicit uncertainty. Implicit uncertainty is linked to the decision-making process, and while understood, it is not displayed or revealed separately from the data. In contrast, explicit uncertainty is conceived as separate from the process and is something that can be described or displayed. Developed from twelve interviews with Phoenix-area water managers in 2005, these distinctions of uncertainty clarify the use of GIS in decision making. Findings show that managers use the products of GIS for exploring uncertainty (e.g., cartographic products). Uncertainty visualization emerged as a current practice, but definitions of what constitutes such visualizations were not consistent across decision makers. Additionally, uncertainty was a common and even sometimes helpful element of decision making; rather than being a hindrance, it is seen as an essential component of the process. These findings contradict prior research relating to uncertainty visualization where decision makers often express discomfort with the presence of uncertainty.

The Influence of Faith on Women in Leadership Positions

Women are still underrepresented in leadership roles and still suffer from gender stereotypes and injustice. Women of faith are frequently stigmatized by both their faith and place of employment. This study is about women of faith who held leadership roles in rural communities. The objective of this study is to examine the experiences of women of faith in leadership, their qualities, and knowledge as effective leaders. The data used in this study is secondary and it was obtained from a parent study entitled, “Women Ascending to Leadership Positions in Rural Nonprofit Organizations.” This parent study used a snowball approach to interview 32 women who were serving in leadership roles in rural nonprofit organizations. The current study used a phenomenological qualitative approach to determine how their faith influenced their leadership ascension. It is necessary to investigate the journey of women’s leadership development to identify how to best develop future female leaders in nonprofit organizations in rural communities. There is limited research regarding women’s leadership experiences in rural organizations and faith

Accounting for Work from Home in the Time of COVID

Objective: As our university moved to a work from home model in response to the COVID-19 pandemic, our research unit needed to reconsider how we accounted for our daily work. Our objective was to consolidate and standardize our data collection to meet requirements for a variety of different time-, project-, or college/program-based reports. Methods: We started by reviewing all the data elements that we might be asked to provide for internal and external reporting. Using the categories in our university activity report as the foundation, we discussed the level of granularity required and assigned activities to each group. We established common reportable elements, with the ability to add individual- or project-specific elements. We tested the categories using our real activities, regrouped to discuss challenges, and made changes as needed. Results: With the start of the new fiscal year, we incorporated these categories into Timeneye and now use them to track our activities. We export these data on a regular basis as our timesheet for the university to meet its work from home requirements. So far, this system also has been effective for creating time-, project-, or college/program-based reports. Conclusions: This project streamlined the process of tracking our time and facilitated the creation of ad hoc reports. It has made it easier for us to track our time across the unit and it will also make it easier for new hires to account for their time in a logical manner

Systematic overview of economic evaluations of health-related rehabilitation

Background: Health related rehabilitation is instrumental in improving functioning and promoting participation by people with disabilities. To make clinical and policy decisions about health-related rehabilitation, resource allocation and cost issues need to be considered. Objectives: To conduct an overview of systematic reviews (SRs) on economic evaluations of health-related rehabilitation. Methods: We searched multiple databases to identify relevant SRs of economic evaluations of health-related rehabilitation. Review quality was assessed by AMSTAR checklist. Results: We included 64 SRs, most of which included economic evaluations alongside randomised controlled trials (RCTs). The review quality was low to moderate (AMSTAR score 5-8) in 35, and high (score 9-11) in 29 of the included SRs. The included SRs addressed various health conditions, including spinal or other pain conditions (n=14), age-related problems (11), stroke (7), musculoskeletal disorders (6), heart diseases (4), pulmonary (3), mental health problems (3), and injury (3). Physiotherapy was the most commonly evaluated rehabilitation intervention in the included SRs (n=24). Other commonly evaluated interventions included multidisciplinary programmes (14); behavioural, educational or psychological interventions (11); home-based interventions (11); complementary therapy (6); self-management (6); and occupational therapy (4). Conclusions: Although the available evidence is often described as limited, inconsistent or inconclusive, some rehabilitation interventions were cost-effective or showed cost-saving in a variety of disability conditions. Available evidence comes predominantly from high income countries, therefore economic evaluations of health-related rehabilitation are urgently required in less resourced settings

Followup Observations of SDSS and CRTS Candidate Cataclysmic Variables

We present photometry of 11 and spectroscopy of 35 potential cataclysmic variables from the Sloan Digital Sky Survey, the Catalina Real-Time Transient Survey and vsnet-alerts. The photometry results include quasi-periodic oscillations during the decline of V1363 Cyg, nightly accretion changes in the likely Polar (AM Herculis binary) SDSS J1344+20, eclipses in SDSS J2141+05 with an orbital period of 76+/-2 min, and possible eclipses in SDSS J2158+09 at an orbital period near 100 min. Time-resolved spectra reveal short orbital periods near 80 min for SDSS J0206+20, 85 min for SDSS J1502+33, and near 100 min for CSS J0015+26, RXS J0150+37, SDSS J1132+62, SDSS J2154+15 and SDSS J2158+09. The prominent HeII line and velocity amplitude of SDSS J2154+15 are consistent with a Polar nature for this object, while the lack of this line and a low velocity amplitude argue against this classification for RXS J0150+37. Single spectra of 10 objects were obtained near outburst and the rest near quiescence, confirming the dwarf novae nature of these objects.Comment: 34 pages, 14 figures, in press at A

Healthy Ageing in Europe:Prioritizing Interventions to improve Health Literacy

Background: Health literacy (HL) is low for 40-50% of the population in developed nations, and is strongly linked to many undesirable health outcomes. Older adults are particularly at risk. The Irohla project systematically created a large inventory of HL interventions targeting adults age 50+, to support practical production of policy and practice guidelines for promoting health literacy in European populations. Methods: We comprehensively surveyed international scientific literature, grey literature and other sources (published 2003+) for implemented HL interventions that involved older adults. Studies were screened for eligibility criteria and further selected for aspects important in European public health policy, including priority diseases, risk factors and vulnerable target groups. Interventions were prioritised using a multiple criteria tool to select final interventions that also featured strong evidence of efficacy and a broad range of strategies. Results: From nearly 7000 written summaries, 1097 met inclusion criteria, of which 233 were chosen for scoring and ranking. Of these, 7 had the highest multi-criteria scores. Eight more articles were selected based on rounded criteria including a high multi-criteria score as well as elements of innovation. Final selections were 18 articles describing 15 programmes. Conclusions: 15 promising intervention projects that feature strong evidence of efficacy among important diseases or risk factors and vulnerable groups, or that had success with elements of innovation were identified. These programmes have multiple positive attributes which could be used as guidance for developing innovative intervention programmes to trial on European older adults. They provide evidence of efficacy in addressing high priority diseases and risk factors