Anisotropic RKKY interaction in semi-Dirac semimetals

In $d$-dimensional systems with purely linear dispersion, the Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction typically follows an isotropic decaying law $J_{iso}\propto {\rm sin}\left(2k_FR\right)/R^d$ ($1/R^{d+\zeta}$) in doped (undoped) case, where $|\omega|^{\zeta}$ denotes the density of states (DOS). However, this law is not valid in semi-Dirac semimetal (S-DSM), which is noted for its anisotropic dispersion, i.e., linear in certain axes but parabolic in the orthogonal axes. By exploring the magnetic interaction in $2$-dimensional (2D) S-DSM and two types of 3D S-DSMs, new laws are derived for the direction-dependent RKKY interaction. Compared to $J_{iso}$, the interaction here decays much more slowly with the impurity distance $R$ as impurities are deposited on the relativistic axis, while a faster decaying law is exhibited with impurities deposited on the non-relativistic axis. The former is induced by the prolonged decaying rate of the carrier propagator and the modified DOS with smaller power $\zeta$, while the latter is caused by the modification to the energy of the carrier propagator. The both are attributed to the anisotropy of the semi-Dirac dispersion. We have further discussed the case with spin-momentum locking. Some phenomena (not exist in DSMs) are highlighted, including the strong magnetic anisotropy with $XYZ$ spin model, and the creation (annihilation) of Dzyaloshinskii-Moriya (DM) terms with impurities deposited on the relativistic (non-relativistic) axis. Our work provides an alternative option to identify the anisotropic nature of semi-Dirac dispersion by measuring the RKKY interaction

Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling

The phytohormone abscisic acid (ABA) regulates plant growth, development and responses to biotic and abiotic stresses. The core ABA signaling pathway consists of three major components: ABA receptor (PYR1/PYLs), type 2C Protein Phosphatase (PP2C) and SNF1-related protein kinase 2 (SnRK2). Nevertheless, the complexity of ABA signaling remains to be explored. To uncover new components of ABA signal transduction pathways, we performed a yeast two-hybrid screen for SnRK2-interacting proteins. We found that Type One Protein Phosphatase 1 (TOPP1) and its regulatory protein, At Inhibitor-2 (AtI-2), physically interact with SnRK2s and also with PYLs. TOPP1 inhibited the kinase activity of SnRK2.6, and this inhibition could be enhanced by AtI-2. Transactivation assays showed that TOPP1 and AtI-2 negatively regulated the SnRK2.2/3/6-mediated activation of the ABA responsive reporter gene RD29B, supporting a negative role of TOPP1 and AtI-2 in ABA signaling. Consistent with these findings, topp1 and ati-2 mutant plants displayed hypersensitivities to ABA and salt treatments, and transcriptome analysis of TOPP1 and AtI-2 knockout plants revealed an increased expression of multiple ABA-responsive genes in the mutants. Taken together, our results uncover TOPP1 and AtI-2 as negative regulators of ABA signaling. © 2016 Hou et al

A STUDY ON THE INHIBITORY EFFECT OF RADIX SEMIAQUILEGIAE EXTRACT ON HUMAN HEPATOMA HEPG-2 AND SMMC-7721 CELLS

The main objective of this paper was to investigate the extraction process of ethanol extract of Radix Semiaquilegiae, as well as its inhibitory activity on human hepatoma HepG-2 and SMMC-7721 cells, and to compare the inhibitory effects of different concentrations of ethanol extracts against these two hepatoma cells. Ethanol reflux extraction and ultrasound-assisted extraction with ethanol at room temperature were used in the extraction process, and MTT assay was mainly used in the activity experiment to perform in-vitro anti HepG-2 and SMMC-7721 cell activity screening of ethanol extract, and to calculate the cell inhibition rates of the extracts. The results showed that among the two types of extracts, ethanol reflux extract had more superior antitumour activity to that of the ultrasonic extract, but all of the extracts obtained had certain anti-cancer activities, and the anti-proliferative activity increased with the increase of concentration

LL37 Inhibits Aspergillus fumigatus Infection via Directly Binding to the Fungus and Preventing Excessive Inflammation

The incidence of Aspergillus fumigatus infection and the rate of resistance to antifungal drugs have sharply increased in recent years. LL37 has been reported as a host defense peptide with broad-spectrum antibacterial activities. However, the role of LL37 during A. fumigatus infection remains unclear. Here, we examined the interaction between LL37 and A. fumigatus and found that synthetic LL37 could directly bind to the surface of A. fumigatus, disrupting the integrity of the cell wall in vitro. LL37 inhibited mycelial growth in a concentration-dependent manner, rather than fungicidal effect even at high concentration (e.g., 20 μM). Interestingly, low concentrations of LL37 (e.g., 4 μM) significantly attenuated mycelial adhesion and prevented the invasion and destruction of epithelial cells. Following LL37 treatment, the levels of proinflammatory cytokines released by A. fumigatus-stimulated macrophages decreased significantly, accompanied by downregulation of M1 type markers. In a mouse model of pulmonary A. fumigatus infection, LL37-treated mice showed lower amounts of fungi load, moderate pathological damage, and reduced proinflammatory cytokines. Further, LL37 transgenic mice (LL37+/+) were examined to investigate the effects of endogenous LL37 in an A. fumigatus infection model and showed lower susceptibility to A. fumigatus infection in comparison with wild-type mice. In addition, LL37 also played a protective role in an immunosuppressed mouse model of A. fumigatus infection. Thus, LL37 inhibits A. fumigatus infection via directly binding to mycelia and reducing excessive inflammation. LL37 or its analogs may therefore constitute potential drug components for A. fumigatus infection

Maximal Violation of Bell's Inequalities for Continuous Variable Systems

We generalize Bell's inequalities to biparty systems with continuous quantum variables. This is achieved by introducing the Bell operator in perfect analogy to the usual spin-1/2 systems. It is then demonstrated that two-mode squeezed vacuum states display quantum nonlocality by using the generalized Bell operator. In particular, the original Einstein-Podolsky-Rosen entangled states, which are the limiting case of the two-mode squeezed vacuum states, can maximally violate Bell's inequality due to Clauser, Horne, Shimony and Holt. The experimental aspect of our scheme and nonlocality of arbitrary biparticle entangled pure states of continuous variables are briefly considered.Comment: RevTEX, 4 pages, no figure. An important note was adde