19,616 research outputs found
Multi-Scale Investigation of Protein-Protein Interactions
Heringa, J. [Promotor]Feenstra, K.A. [Copromotor
Simulating unsteady conduit flows with smoothed particle hydrodynamics
Pipelines are widely used for transport and cooling in industries such as oil and gas, chemical, water supply and sewerage, and hydro, fossil-fuel and nuclear power plants. Unsteady pipe flows with large pressure variations may cause a range of problems such as pipe rapture, support failure, pipe movement, vibration and noise. The unsteady flow is generally caused by flow velocity changes due to valve or pump operation. Water hammer is the best known and extensively studied phenomenon in this respect. Fast transient may also occur in rapid pipe filling and emptying processes. Due to high driving heads, the advancing liquid column may achieve a high velocity. When this high-velocity column is blocked or restricted in its flow, high water-hammer pressures may result. Another scenario is that of slug flow, which arguably is the most dangerous type of two-phase pipe flow. Heavy isolated liquid slugs travelling at high speed behave like cannonballs. Damage is likely to happen when these slugs impact on barriers such as pumps, bends and partially closed valves. Advancing liquid columns occurring in rapid pipe filling and emptying can be seen as a special case of isolated slugs. In this thesis, we present a Lagrangian particle method for solving the Euler equations with application to water hammer, rapid pipe filling and emptying, and isolated slugs travelling in an empty pipeline. As a meshfree method, the smoothed particle hydrodynamics (SPH) used herein is suitable for problems encompassing moving boundaries and impact events, which are the common features of the concerned topics. We first present the kernel and particle approximation concepts, which are two essential steps in SPH. Based on numerical approximation rules, the SPH discrete form of the Euler and Navier-Stokes equations are derived. To treat various boundary conditions, we apply several types of image particles that are particularly designed to complete the kernels truncated by system boundaries. The global conservation of mass and linear momentum is then demonstrated. The SPH errors in the integral approximation and summation approximation are analyzed based on given particle distribution patterns. Several other problems such as particle clustering, tensile instability, particle boundary layer and lacking of polynomial reproducing abilities (incompleteness) are also discussed together with possible remedies. Before applying the implemented particle solver to the thesis topics, we first thoroughly test it against a selection of two-dimensionale benchmarks, which have close relationship with the concerned problems. They include dam-break, jet impinging onto an inclined plane, emerging jet under gravity, free overfall and flow separation at bends. Good agreements with analytical and numerical solutions in literature are found. The convergence rate of SPH is shown to be of first order, which is consistent with the theoretical analysis. For the rapid pipe filling problem, we apply the 1D SPH solver to the experiment of Liou & Hunt [114]. The velocity head at the inlet has to be taken into account to obtain a good agreement with the experiment. Water elasticity does not play a role and the friction formulation for steady state flows can be used. Head transition analysis provides deeper insight into the hydrodynamic behaviour in the filling process. As a special case of pipe filling, water hammer due to liquid impact at partially and fully closed valves is studied. The results agree well with standard MOC solutions. Similar observations are made for the rapid emptying process. For the isolated slug travelling in a voided pipeline and impacting on a bend, we apply the 1D and 2D SPH solvers to the experiments of Bozkus [24]. To obtain the arrival velocity of the slug at the elbow, a 1D model including mass loss at the slug tail is used. In the slug impact, flow separation at the bend plays a vital role, which is typical 2D flow behaviour at a geometrical discontinuity. With the flow contraction coefficient obtained from 2D SPH solutions, the improved 1D model gives good results for the reaction force, not only in magnitude but also its duration and shape. Finally, to study the evolutions of air/water interface and its possible effect on filling and emptying processes, a new experimental study is performed in a large-scale pipeline. It is found that in filling the water front tends to split into two fronts propagating with different velocities. This results in air intrusion on top of a water platform. In emptying, flow stratification occurs at the water tail. Consequently, the validated assumption of vertical air/water interfaces for small-scale system with high driving head may not be applicable to large-scale systems. The interface evolution does not play an important role in pipe filling, the overall behaviour of which can be well predicted with 1D SPH solutions. However, flow stratification largely affects the overall draining process
Joint effect of the western and eastern Pacific warm pools on ENSO cycle
International audienceThe zonal displacement of the western Pacific warm pool (WPWP) and the meridional displacement of the eastern Pacific warm pool (EPWP) and their responses to wind anomalies over the tropical Pacific were investigated. Joint effect of the WPWP and EPWP on ENSO was examined based on a joint effect index, which is a combination of the standardized anomaly time series of the eastern edge of the WPWP and the southern edge of the EPWP. Results show that both WPWP and EPWP are major providers of warm water in the eastern equatorial Pacific. The anomalous eastward extension of the WPWP and abnormal southward extension of the EPWP can supply a large amount of warm water into Nino3 region of the north equator, result in dramatic local SST increase, and trigger El Niño. To the contrary, as scope of the WPWP retreats westward and the EPWP retreats northward, a La Niña will outburst. One cannot separate apart the roles played by the WPWP and EPWP on ENSO, and the joint effect of both warm pools must be considered. A joint index of 1.6 means a new El Niño event is likely to happen
Modified smoothed particle method and its application to transient heat conduction
Inspired by the idea of applying kernel approximation to Taylor series expansions proposed in the corrective smoothed particle method (CSPM), a modi¿cation is developed to improve the accuracy of the approximations especially for particles in the boundary region. The large global error of the function approximation in CSPM is reduced in the present method. The large local truncation error in the boundary region for the ¿rst derivative approximation and large local truncation error in the entire domain for the second derivative approximation are also resolved. The e¿ciency of the proposed method is demonstrated by solving one- and two-dimensional transient heat conduction problems
TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a
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