Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation (Scientific Reports DOI: 10.1038/s41598-018-22819-3)

peer reviewe

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19(1,2), host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases(3-7). They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.Peer reviewe

Wanderlust : actions, traces, journeys, 1967-2017 /

"Published on the occasion of the exhibition, Wanderlust: actions, traces, journeys, 1967-2017, UB Art Galleries, September 7-December 30, 2017, Des Moines Art Center, February 18-May 13, 2018. Curator: Rachel Adams"--Title page verso.Includes bibliographical references.Excerpt from Wanderlust : a history of walking / Rebecca Solnit -- Actions, traces, journeys / Rachel Adams -- Keep on walking / Lori Waxman -- Trips, tours, traces, trespassings (and other tropes for wandering) / Jane McFadden

Benthic inventory of reefal areas in Moreton Bay, Australia

The study involved the collection of field data and acquisitioning of satellite imagery to create a map that presents a benthic inventory of reefal habitat areas within Moreton Bay. Mapping was guided by the most recent reef map (Queensland Environmental Protection Agency, 2004), the new field data, local knowledge and/or visual interpretation of high spatial resolution satellite imagery.The inventories for each reefal area were based on georeferenced spot check field data collected by volunteer teams in 2015 and 2016 (n=610). This field data was overlayed on high spatial resolution ZY-3 satellite imagery (5 m x 5 m pixels) captured in June 2014. Polygons were manually digitised around reefal areas by an expert from the Remote Sensing Research Centre using visual interpretation of the texture and colour of the pixels in the satellite imagery, as related to water depth, field data and local field knowledge. Polygons were subsequently assigned one of three categories (Coral on reef matrix, Soft Coral on Sand/Rubble, and, Algae on sand/rubble)

Benthic inventory of reefal areas in Moreton Bay, Australia

The study involved the collection of field data and acquisitioning of satellite imagery to create a map that presents a benthic inventory of reefal habitat areas within Moreton Bay. Mapping was guided by the most recent reef map (Queensland Environmental Protection Agency, 2004), the new field data, local knowledge and/or visual interpretation of high spatial resolution satellite imagery. The inventories for each reefal area were based on georeferenced spot check field data collected by volunteer teams in 2015 and 2016 (n=610). This field data was overlayed on high spatial resolution ZY-3 satellite imagery (5 m x 5 m pixels) captured in June 2014. Polygons were manually digitised around reefal areas by an expert from the Remote Sensing Research Centre using visual interpretation of the texture and colour of the pixels in the satellite imagery, as related to water depth, field data and local field knowledge. Polygons were subsequently assigned one of three categories (Coral on reef matrix, Soft Coral on Sand/Rubble, and, Algae on sand/rubble). The project was a collaborative citizen science project between Reef Check Australia, The University of Queensland Remote Sensing Research Centre and Healthy Waterways to collect benthic inventories for eight key subtropical reefal areas in Central Moreton Bay - Mud, Saint Helena, Green, King, Macleay, Goat, and Peel Islands, and, Myora Reef

Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation

peer reviewe