Computational Intelligence Modeling of Pharmaceutical Properties

Proceedings of the First PhD Symposium on Sustainable Ultrascale Computing Systems (NESUS PhD 2016) Timisoara, Romania. February 8-11, 2016.In the pharmaceutical industry, a good understanding of the casual relationship between product quality and attributes of formulations is very useful in developing new products, and optimizing manufacturing processes. Feature selection is mandatory due to the abundance of noisy, irrelevant, or misleading features. The selected features will improve the performance of the prediction model and will provide a faster and more cost effective prediction than using all the features. With the big data captured in the pharmaceutical product development practice, computational intelligence (CI) models and machine learning algorithms could potentially be used to identify the process parameters of formulations and manufacturing processes. That needs a deep investigation of roller compaction process parameters of pharmaceutical formulations that affect the ribbons production. In this work, we are using the bio-inspired optimization algorithms for feature selection such as (grey wolf, Bat, flower pollination, social spider, antlion, moth-flame, genetic algorithms, and particle swarm) to predict the different pharmaceutical properties.European Cooperation in Science and Technology. COSTThis work was supported by the IPROCOM Marie Curie initial training network, funded through the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme FP7/2007-2013/ under REA grant agreement No. 316555. In addition, this work was partially supported by NESUS

COVID-19 Prediction Using LSTM Algorithm: GCC case study

Coronavirus-19 (COVID-19) is the black swan of 2020. Still, the human response to restrain the virus is also creating massive ripples through different systems, such as health, economy, education, and tourism. This paper focuses on research and applying Artificial Intelligence (AI) algorithms to predict COVID-19 propagation using the available time-series data and study the effect of the quality of life, the number of tests performed, and the awareness of citizens on the virus in the Gulf Cooperation Council (GCC) countries at the Gulf area. So we focused on cases in the Kingdom of Saudi Arabia (KSA), United Arab of Emirates (UAE), Kuwait, Bahrain, Oman, and Qatar. For this aim, we accessed the time-series real-datasets collected from Johns Hopkins University Center for Systems Science and Engineering (JHU CSSE). The timeline of our data is from January 22, 2020 to January 25, 2021. We have implemented the proposed model based on Long Short-Term Memory (LSTM) with ten hidden units (neurons) to predict COVID-19 confirmed and death cases. From the experimental results, we confirmed that KSA and Qatar would take the most extended period to recover from the COVID-19 virus, and the situation will be controllable in the second half of March 2021 in UAE, Kuwait, Oman, and Bahrain. Also, we calculated the root mean square error (RMSE) between the actual and predicted values of each country for confirmed and death cases, and we found that the best values for both confirmed and death cases are 320.79 and 1.84, respectively, and both are related to Bahrain. While the worst values are 1768.35 and 21.78, respectively, and both are related to KSA. On the other hand, we also calculated the mean absolute relative errors (MARE) between the actual and predicted values of each country for confirmed and death cases, and we found that the best values for both confirmed and deaths cases are 37.76 and 0.30, and these are related to Kuwait and Qatar respectively. While the worst values are 71.45 and 1.33, respectively, and both are related to KSA

Performance Evaluation of Ingenious Crow Search Optimization Algorithm for Protein Structure Prediction

Protein structure prediction is one of the important aspects while dealing with critical diseases. An early prediction of protein folding helps in clinical diagnosis. In recent years, applications of metaheuristic algorithms have been substantially increased due to the fact that this problem is computationally complex and time-consuming. Metaheuristics are proven to be an adequate tool for dealing with complex problems with higher computational efficiency than conventional tools. The work presented in this paper is the development and testing of the Ingenious Crow Search Algorithm (ICSA). First, the algorithm is tested on standard mathematical functions with known properties. Then, the application of newly developed ICSA is explored on protein structure prediction. The efficacy of this algorithm is tested on a bench of artificial proteins and real proteins of medium length. The comparative analysis of the optimization performance is carried out with some of the leading variants of the crow search algorithm (CSA). The statistical comparison of the results shows the supremacy of the ICSA for almost all protein sequences

Optimal Design of Photovoltaic, Biomass, Fuel Cell, Hydrogen Tank units and Electrolyzer hybrid system for a remote area in Egypt

In this paper, a new isolated hybrid system is simulated and analyzed to obtain the optimal sizing and meet the electricity demand with cost improvement for servicing a small remote area with a peak load of 420 kW. The major configuration of this hybrid system is Photovoltaic (PV) modules, Biomass gasifier (BG), Electrolyzer units, Hydrogen Tank units (HT), and Fuel Cell (FC) system. A recent optimization algorithm, namely Mayfly Optimization Algorithm (MOA) is utilized to ensure that all load demand is met at the lowest energy cost (EC) and minimize the greenhouse gas (GHG) emissions of the proposed system. The MOA is selected as it collects the main merits of swarm intelligence and evolutionary algorithms; hence it has good convergence characteristics. To ensure the superiority of the selected MOA, the obtained results are compared with other well-known optimization algorithms, namely Sooty Tern Optimization Algorithm (STOA), Whale Optimization Algorithm (WOA), and Sine Cosine Algorithm (SCA). The results reveal that the suggested MOA achieves the best system design, achieving a stable convergence characteristic after 44 iterations. MOA yielded the best EC with 0.2106533 $/kWh, the net present cost (NPC) with 6,170,134$, the loss of power supply probability (LPSP) with 0.05993%, and GHG with 792.534 t/y

Feature Selection via Chaotic Antlion Optimization

Selecting a subset of relevant properties from a large set of features that describe a dataset is a challenging machine learning task. In biology, for instance, the advances in the available technologies enable the generation of a very large number of biomarkers that describe the data. Choosing the more informative markers along with performing a high-accuracy classification over the data can be a daunting task, particularly if the data are high dimensional. An often adopted approach is to formulate the feature selection problem as a biobjective optimization problem, with the aim of maximizing the performance of the data analysis model (the quality of the data training fitting) while minimizing the number of features used.This work was partially supported by the IPROCOM Marie Curie initial training network, funded through the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme FP7/2007-2013/ under REA grants agreement No. 316555, and by the Romanian National Authority for Scientific Research, CNDIUEFISCDI, project number PN-II-PT-PCCA-2011-3.2- 0917. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Impact of Chaos Functions on Modern Swarm Optimizers.

Exploration and exploitation are two essential components for any optimization algorithm. Much exploration leads to oscillation and premature convergence while too much exploitation slows down the optimization algorithm and the optimizer may be stuck in local minima. Therefore, balancing the rates of exploration and exploitation at the optimization lifetime is a challenge. This study evaluates the impact of using chaos-based control of exploration/exploitation rates against using the systematic native control. Three modern algorithms were used in the study namely grey wolf optimizer (GWO), antlion optimizer (ALO) and moth-flame optimizer (MFO) in the domain of machine learning for feature selection. Results on a set of standard machine learning data using a set of assessment indicators prove advance in optimization algorithm performance when using variational repeated periods of declined exploration rates over using systematically decreased exploration rates

Mean fitness values for the GWO versus CGWO using the Singer function.

<p>Mean fitness values for the GWO versus CGWO using the Singer function.</p