Design and Performance of Superconducting Magnets for Hybrid Magnets(Part I. Establishment and Tests of Hybrid Magnet System at HFLSM)

Design, construction and performance of three superconducting magnets for the hybrid magnets installed in the High Field Laboratory for Superconducting Materials are described in detail. The compact solenoid, SM-3, without fully cryostable design forms the outer part of the most compact hybrid magnet in the world, HM-3 (32 mm bore, 20 T). Fully cryostable superconducting magnet designed under the Steckly criterion, SM-2, is the outer part of HM-2 (52 mm bore, 23 T), which has been most attractive to many experimentalists. SM-1, the outer part of HM-1 (32/52 mm bore, 31/28 T), with the Williams cryostability criterion is the world largest one of the superconducting magnets which employ Ti-doped Nb_3Sn multifilamentary conductors and can generate more than 12 T

Multiple small hemorrhagic infarcts in cerebral air embolism: a case report

Abstract Background Cerebral air embolism is a rare cause of cerebral infarction. In cerebral air embolism, T2 star-weighted imaging shows numerous spotty hypointense signals. Previous reports have suggested that these signals represent air in the brain and are gradually diminished and absorbed. We experienced two cases of cerebral air embolism, and in one of them, we conducted an autopsy. Case presentation Case 1 was a 76-year-old Japanese man with lung cancer and emphysema. A spasmodic cough induced massive cerebral and cardiac air embolisms and the patient died because of cerebral herniation. T2 star-weighted imaging of brain magnetic resonance imaging showed multiple spotty low signals. Brain autopsy showed numerous spotty hemorrhagic infarcts in the area of T2 star-weighted imaging signals. Case 2 was an 85-year-old Japanese man with emphysema who suffered from acute stroke. Similar spotty T2 star-weighted imaging signals were observed and remained unchanged 2 months after the onset. Conclusions These findings indicate that T2 star-weighted imaging in cerebral air embolism partially represents micro-hemorrhagic infarction caused by air bubbles that have migrated into the brain

A Double-Blind, Randomized, Crossover Comparative Study for Evaluating the Clinical Safety of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE)

Ephedra Herb is an important crude drug; it is used in various Traditional Japanese Medicine (Kampo) formulations. Its significant pharmacological effects have been believed to be attributed to ephedrine and pseudoephedrine, which sometimes induce adverse effects. On the other hand, it has been reported that some of these pharmacological effects are not dependent on ephedrine or pseudoephedrine. Ephedrine alkaloids-free Ephedra Herb extract has been newly developed. It has been reported to have analgesic, anti-influenza, and antimetastatic effects. This clinical trial was aimed at verifying the noninferiority of EFE’s safety compared to that of Ephedra Herb extract (EHE) in humans. This was a single-institution, double-blinded, randomized, two-drug, two-stage, crossover comparative study. Twelve healthy male subjects were equally and randomly allocated into two groups: prior administration of EFE (EFE-P) and prior administration of EHE (EHE-P). In Stage 1, EFE and EHE were orally administered to the EFE-P and EHE-P groups, respectively, for six days. After a 4-week washout period, Stage 2 was initiated wherein the subjects were given a study drug different from Stage 1 study drug for six days. Eleven adverse events with a causal relationship to the study drugs (EHE: 8; EFE: 3) were noted; all events were mild in severity. With regard to the incidence of adverse events, EHE and EFE administration, respectively, accounted for 4 cases (out of 12 subjects, similarly below) and 1 case of increased pulse rate (p=0.32) and 3 cases and 1 case of insomnia (p=0.59). Further, there was one case of hot flashes (p=1.00) due to EFE administration and one case of dysuria (p=1.00) due to EHE administration. There were no significant differences in the incidences of adverse events between EHE administration and EFE administration. Therefore, we concluded that EFE is not inferior to EHE in terms of safety

INVESTIGATION ON APPLICABILITY OF MOISTURE DETECTION TECHNOLOGY BETWEEN PAVEMENT LAYERS BY ELECTRICAL RESISTANCE

舗装ひび割れ部や縁石・地覆前面の舗装端部などから浸入した雨水や融雪水は，舗装層間などの空隙を通じて舗装体内に広がり，層間剥離やポットホール発生の要因となっている．さらに，凍結融解作用が加わると，このような舗装損傷が加速する．このため，舗装内への水分の浸入を抑制する適切な止水技術や補修方法が求められている．本研究では，舗装層間に浸入した水分を直接検知する技術の開発を目的として，電気抵抗の計測による水分検知技術の適用性について室内および屋外において検討した．その結果，舗装層間に銅箔を用いた電極を埋設し，電気抵抗を計測することにより，層間の水分検知が可能であることが明らかになったことから，本研究で提案する技術は，止水技術等の性能評価に利用できる可能性が示唆された．Rainwater and snowmelt water enter from cracks in the pavement and from the edges of pavement. These waters spread between the layers of pavement. And it causes delamination and potholes. Furthermore, the addition of freeze-thaw action to these accelerates pavement damage. Therefore, a technology that appropriately suppresses the ingress of water is required. The purpose of this research is to develop a technology to detect the moisture between layers of pavement. This technology is necessary to evaluate the performance of the technology that suppresses the ingress of water. In this study, the applicability of technology to detect moisture by measuring electrical resistance is discussed. Electrical resistance was measured using copper foil electrodes. Based on the various test results, it was found that the developed technology can be detected the moisture infiltrated between the layers of pavement