Exercise-Based Strategies to Prevent Muscle Injury in Male Elite Footballers: An Expert-Led Delphi Survey of 21 Practitioners Belonging to 18 Teams from the Big-5 European Leagues.

PurposeTo define based on expert opinion and practical experience using a systematic and scientific approach, (1) the perceived most effective exercise-based strategies to prevent muscle injury in elite footballers; and, (2) when and how these exercise programs are prescribed based on the number of days between games i.e. implementation strategy.MethodsA Delphi survey obtained opinions and assessed for agreement. Delphi respondents consisted of 21 experienced sports practitioners (12 ± 5.3 years in elite football and with an academic background) belonging to 18 teams from the Big-5 European football leagues; England, France, Germany, Italy, Spain. Three teams were represented collaboratively by two experts. The Delphi process involves sequential rounds each evolving based on the responses from the previous. The number of rounds is not pre-defined and continues until an agreement is either achieved or it is clear that no agreement will be reached. Frequency of responses was recorded where the agreement was sought (i.e. in closed questions) and an agreement was achieved if ≥ 13/18 (70%) respondents agreed. For open-ended questions, a qualitative content analysis was performed to identify recurring themes and when themes were specified by ≥ 13 (70%), these were also considered as reaching an agreement. Practitioners had the opportunity to raise concerns if they disagreed with the 'agreement from recurrent themes'.ResultsThere were four Delphi rounds (100% response for each round). Sprinting and High-Speed Running (HSR) focused exercises were agreed as most effective (perceived) to prevent muscle injuries. Eccentric exercise was perceived as the next most effective. It was agreed that sprinting and HSR be integrated into coaches training, and target 100% of players worst-case match scenario (e.g. volume, intensity) based on individual maximum speeds. Eccentric exercise was recommended to be implemented according to the context of the main football session and planned/actual sprinting and HSR content. It was agreed that eccentrics can be performed before or after training, context dependent. The day to perform specific sprinting and HSR or eccentric exercises depended on the proximity of previous and upcoming matches. Other exercises reaching agreement as 'somewhat effective' included concentric and isometric, horizontal and vertical plyometrics, coordination, core and dynamic flexibility in addition to core stability. No agreement was reached for multi-joint, resisted sprinting, kicking or agility exercises nor simultaneous single-leg strength and stability. Finally, no agreement was reached regarding programming variables e.g. sets, repetitions as deemed too contextual.ConclusionRegarding exercise-based strategies, particular importance agreed by the Delphi expert group was to focus on sprinting, HSR and eccentric exercises, integrated with a variety of other exercise modes which also carry some level of effectiveness in a multidimensional programme. Context was agreed to be key and decision-making about when to undertake/ how to prescribe exercise strategies to be made according to the content of normal football training and the proximity of matches

A detailed radio study of the energetic, nearby, and puzzling GRB 171010A

We present the results of an intensive multi-epoch radio frequency campaign on the energetic and nearby GRB 171010A with the Karl G. Janksy Very Large Array and Arcminute Microkelvin Imager Large Array. We began observing GRB 171010A a day after its initial detection, and were able to monitor the temporal and spectral evolution of the source over the following weeks. The spectra and their evolution are compared to the canonical theories for broadband GRB afterglows, with which we find a general agreement. There are, however, a number of features that are challenging to explain with a simple forward shock model, and we discuss possible reasons for these discrepancies. This includes the consideration of the existence of a reverse shock component, potential microphysical parameter evolution and the effect of scintillation

A LOFAR DETECTION of the LOW-MASS YOUNG STAR T TAU at 149 MHz

© 2017 Published by Elsevier B.V. Radio observations of young stellar objects (YSOs) enable the study of ionized plasma outflows from young protostars via their free-free radiation. Previous studies of the low-mass young system T Tau have used radio observations to model the spectrum and estimate important physical properties of the associated ionized plasma (local electron density, ionized gas content, and emission measure). However, without an indication of the low-frequency turnover in the free-free spectrum, these properties remain difficult to constrain. This paper presents the detection of T Tau at 149 MHz with the Low Frequency Array (LOFAR)-the first time a YSO has been observed at such low frequencies. The recovered total flux indicates that the free-free spectrum may be turning over near 149 MHz. The spectral energy distribution is fitted and yields improved constraints on local electron density ((7.2 ± 2.1) × 103 cm-3), ionized gas mass ( ± × -1.0 1.8 10-6Ṁ), and emission measure ((1.67 ± 0.14) × 105 pc cm-6)

Adenomatous polyposis coli-mediated control of β-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

Background: During skeletogenesis, protein levels of β-catenin in the canonical Wnt signaling pathway determine lineage commitment of skeletal precursor cells to osteoblasts and chondrocytes. Adenomatous polyposis coli (Apc) is a key controller of β-catenin turnover by down-regulating intracellular levels of β-catenin. Results: To investigate whether Apc is involved in lineage commitment of skeletal precursor cells, we generated conditional knockout mice lacking functional Apc in Col2a1-expressing cells. In contrast to other models in which an oncogenic variant of β-catenin was used, our approach resulted in the accumulation of wild type β-catenin protein due to functional loss of Apc. Conditional homozygous Apc mutant mice died perinatally showing greatly impaired skeletogenesis. All endochondral bones were misshaped and lacked structural integrity. Lack of functional Apc resulted in a pleiotropic skeletal cell phenotype. The majority of the precursor cells lacking Apc failed to differentiate into chondrocytes or osteoblasts. However, skeletal precursor cells in the proximal ribs were able to escape the noxious effect of functional loss of Apc resulting in formation of highly active osteoblasts. Inactivation of Apc in chondrocytes was associated with dedifferentiation of these cells. Conclusion: Our data indicate that a tight Apc-mediated control of β-catenin levels is essential for differentiation of skeletal precursors as well as for the maintenance of a chondrocytic phenotype in a spatio-temporal regulated manner

Detailed multiwavelength modelling of the dark GRB 140713A and its host galaxy

We investigate the afterglow of GRB 140713A, a gamma-ray burst (GRB) that was detected and relatively well sampled at X-ray and radio wavelengths, but was not present at optical and near-infrared wavelengths, despite searches to deep limits. We present the emission spectrum of the likely host galaxy at z = 0.935 ruling out a high-redshift explanation for the absence of the optical flux detection. Modelling the GRB multiwavelength afterglow using the radiative transfer hydrodynamics code boxfit provides constraints on physical parameters of the GRB jet and its environment, for instance a relatively wide jet opening angle and an electron energy distribution slope p below 2. Most importantly, the model predicts an optical flux about two orders of magnitude above the observed limits. We calculated that the required host extinction to explain the observed limits in the r, i, and z bands was A rm host-V gt 3.2 mag, equivalent to E(B ' V) host > 1.0 mag. From the X-ray absorption we derive that the GRB host extinction is A rm host-V = 11.6 +7.5-5.3 mag, equivalent to E(B-V) rm host = 3.7 +2.4-1.7 mag, which is consistent with the extinction required from our boxfit derived fluxes. We conclude that the origin of the optical darkness is a high level of extinction in the line of sight to the GRB, most likely within the GRB host galaxy. © 2019 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society

A variable absorption feature in the X-ray spectrum of a magnetar

Soft gamma-ray repeaters (SGRs) and anomalous X-ray pulsars (AXPs) are slowly rotating, isolated neutron stars that sporadically undergo episodes of long-term flux enhancement (outbursts) generally accompanied by the emission of short bursts of hard X-rays. This behaviour can be understood in the magnetar model, according to which these sources are mainly powered by their own magnetic energy. This is supported by the fact that the magnetic fields inferred from several observed properties of AXPs and SGRs are greater than - or at the high end of the range of - those of radio pulsars. In the peculiar case of SGR 0418+5729, a weak dipole magnetic moment is derived from its timing parameters, whereas a strong field has been proposed to reside in the stellar interior and in multipole components on the surface. Here we show that the X-ray spectrum of SGR 0418+5729 has an absorption line, the properties of which depend strongly on the star's rotational phase. This line is interpreted as a proton cyclotron feature and its energy implies a magnetic field ranging from 2E14 gauss to more than 1E15 gauss.Comment: Nature, 500, 312 (including Supplementary Information