398 research outputs found
Steam gasification of rapeseed, wood, sewage sludge and miscanthus biochars for the production of a hydrogen-rich syngas
Steam gasification of biochars has emerged as a promising method for generating syngas that is rich in hydrogen. In this study four biochars formed via intermediate pyrolysis (wood pellet, sewage sludge, rapeseed and miscanthus) were gasified in a quartz tubular reactor using steam. The dynamic behaviour of the process and effects of temperature, steam flow and particle size were studied. The results show that increases in both steam flow and temperature significantly increase the dry gas yield and carbon conversion, but hydrogen volume fraction decreases at higher temperatures whilst particle size has little effect on gaseous composition. The highest volume fraction of hydrogen, 58.7%, was obtained at 750 °C from the rapeseed biochar
Structural design of hydraulic press
Typescript (photocopy).Includes bibliographical references (leaves 77-78)
On the impact of injection schemes on transition in hypersonic boundary layers
Three geometries are explored for injecting CO_2 into the boundary layer of a sharp five degree half-angle cone. The impact of the injection geometry, namely discrete injection holes or a porous conical section, on tripping the boundary layer is examined, both with and without injected flow. The experiments are conducted at Caltech's T5 reflected shock tunnel. Two different air free-stream conditions are explored. For the discrete-hole injectors, the diameter for the injection holes is 0.75 mm nominally and the length to diameter ratio is about 30. One injector has a single row of holes and the other has four rows. With the 4-row geometry fully turbulent heat transfer values are measured within four centimeters of the last injection row for both free-stream conditions. The 1-row injector results on a reduction of 50% in the transition Reynolds number. The porous injector does not move the transition Reynolds number upstream by itself with no injection flow
Carbon Dioxide Injection for Hypervelocity Boundary Layer Stability
An approach for introducing carbon dioxide as a means or stabilizing a hypervelocity boundary layer over a slender bodied vehicle is investigated through the use of numerical simulations. In the current study, two different test bodies are examined. The first is a five-degree-half-angle cone currently under research at the GALCIT T5 Shock Tunnel with a 4 cm porous wall insert used to transpire gas into the boundary layer. The second test body is a similar cone with a porous wall over a majority of cone surface. Computationally, the transpiration is performed using an axi-symmetric flow simulation with wall-normal blowing. The effect of the injection and the transition location are gauged by solving the parabolized stability equations and using the semi-empirical e^N method. The results show transition due to the injection for the first test body and a delay in the transition location for the second test body as compared to a cone without injection under the same flight conditions. The mechanism for the stabilizing effect of carbon dioxide is also explored through selectively applying non-equilibrium processes to the stability analysis. The results show that vibrational non-equilibrium plays a role in reducing disturbance amplification; however, other factors also contribute
Utility of Direct Pancreatic Function Testing in Children
OBJECTIVES: Exocrine pancreatic insufficiency (EPI) can have a significant impact on a child's growth and nutrition. Our aim was to evaluate the utility of direct endoscopic pancreatic function testing (ePFT) in pediatrics. METHODS: A single-center retrospective chart review was performed of children who underwent ePFT from December 2007 through February 2015. Endoscopic pancreatic function testings were performed by 1 of 2 methods: (1) intravenous cholecystokinin, followed by the collection of a single duodenal aspirate at 10 minutes, or (2) intravenous cholecystokinin or secretin, followed by the collection of 3 duodenal aspirates at a 5, 10, and 15 minutes. Samples were tested for pH and enzyme activities. RESULTS: A total of 508 ePFTs were performed (481 single-sample tests, 27 multiple-sample tests). Based on the multiple-sample group, enzyme levels for chymotrypsin, amylase, and lipase peaked at 5 minutes, followed by a decrease in activity over time. Exocrine pancreatic sufficiency was identified in 373 (73.4%) and EPI in 93 (18.3%). Exocrine pancreatic sufficiency analysis found all pancreatic enzyme activities significantly increase with age: trypsin, chymotrypsin, amylase, and lipase, (P < 0.05). CONCLUSIONS: Endoscopic pancreatic function testing can be used in the evaluation of EPI in children. Normative data suggest that pancreatic enzyme activities mature with age
Screening for brain aneurysm in the Familial Intracranial Aneurysm study: frequency and predictors of lesion detection
Object
Approximately 20% of patients with an intracranial saccular aneurysm report a family history of intracranial aneurysm (IA) or subarachnoid hemorrhage. A better understanding of predictors of aneurysm detection in familial IA may allow more targeted aneurysm screening strategies.
Methods
The Familial Intracranial Aneurysm (FIA) study is a multicenter study, in which the primary objective is to define the susceptibility genes related to the formation of IA. First-degree relatives (FDRs) of those affected with IA are offered screening with magnetic resonance (MR) angiography if they were previously unaffected, are ≥ 30 years of age, and have a history of smoking and/or hypertension. Independent predictors of aneurysm detection on MR angiography were determined using the generalized estimating equation version of logistic regression.
Results
Among the first 303 patients screened with MR angiography, 58 (19.1%) had at least 1 IA, including 24% of women and 11.7% of men. Ten (17.2%) of 58 affected patients had multiple aneurysms. Independent predictors of aneurysm detection included female sex (odds ratio [OR] 2.46, p = 0.001), pack-years of cigarette smoking (OR 3.24 for 20 pack-years of cigarette smoking compared with never having smoked, p < 0.001), and duration of hypertension (OR 1.26 comparing those with 10 years of hypertension to those with no hypertension, p = 0.006).
Conclusions
In the FIA study, among the affected patients’ FDRs who are > 30 years of age, those who are women or who have a history of smoking or hypertension are at increased risk of suffering an IA and should be strongly considered for screening
Carbon Dioxide Injection for Hypervelocity Boundary Layer Stability
An approach for introducing carbon dioxide as a means or stabilizing a hypervelocity boundary layer over a slender bodied vehicle is investigated through the use of numerical simulations. In the current study, two different test bodies are examined. The first is a five-degree-half-angle cone currently under research at the GALCIT T5 Shock Tunnel with a 4 cm porous wall insert used to transpire gas into the boundary layer. The second test body is a similar cone with a porous wall over a majority of cone surface. Computationally, the transpiration is performed using an axi-symmetric flow simulation with wall-normal blowing. The effect of the injection and the transition location are gauged by solving the parabolized stability equations and using the semi-empirical e^N method. The results show transition due to the injection for the first test body and a delay in the transition location for the second test body as compared to a cone without injection under the same flight conditions. The mechanism for the stabilizing effect of carbon dioxide is also explored through selectively applying non-equilibrium processes to the stability analysis. The results show that vibrational non-equilibrium plays a role in reducing disturbance amplification; however, other factors also contribute
Association of Environmental Toxicants and Conduct Disorder in U.S. Children: NHANES 2001–2004
ObjectiveThe purpose of this study was to examine the association of tobacco smoke and environmental lead exposure with conduct disorder (CD).MethodsThe National Health and Nutrition Examination Survey (NHANES) 2001–2004 is a nationally representative cross-sectional sample of the noninstitutionalized U.S. population. We examined the association of prenatal tobacco, postnatal tobacco, and environmental lead exposure with CD in children 8–15 years of age (n = 3,081). We measured prenatal tobacco exposure by parent report of cigarette use during pregnancy, and postnatal tobacco using serum cotinine levels. We assessed lead exposure using current blood lead concentration. Parents completed the Diagnostic Interview Schedule for Children to determine whether their children met criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV ) for CD.ResultsOverall, 2.06% of children met DSM-IV criteria for CD in the past year, equivalent to 560,000 U.S. children 8–15 years of age. After adjustment, prenatal tobacco exposure was associated with increased odds for CD [odds ratio (OR) = 3.00; 95% confidence interval (CI), 1.36–6.63]. Increased blood lead levels (fourth vs. first quartile) and serum cotinine levels (fifth vs. first quintile) were associated with an 8.64-fold (95% CI, 1.87–40.04) and 9.15-fold (95% CI, 1.47–6.90) increased odds of meeting DSM-IV CD criteria. Increasing serum cotinine levels and blood lead levels were also associated with increased prevalence of CD symptoms (symptom count ratio, lead: 1.73; 95% CI, 1.23–2.43; symptom count ratio, cotinine: 1.97; 95% CI, 1.15–3.40).ConclusionsThese results suggest that prenatal tobacco exposure and environmental lead exposure contribute substantially to CD in U.S. children
Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis
Lead is a confirmed neurotoxin, but questions remain about lead-associated intellectual deficits at blood lead levels < 10 μg/dL and whether lower exposures are, for a given change in exposure, associated with greater deficits. The objective of this study was to examine the association of intelligence test scores and blood lead concentration, especially for children who had maximal measured blood lead levels < 10 μg/dL. We examined data collected from 1,333 children who participated in seven international population-based longitudinal cohort studies, followed from birth or infancy until 5–10 years of age. The full-scale IQ score was the primary outcome measure. The geometric mean blood lead concentration of the children peaked at 17.8 μg/dL and declined to 9.4 μg/dL by 5–7 years of age; 244 (18%) children had a maximal blood lead concentration < 10 μg/dL, and 103 (8%) had a maximal blood lead concentration < 7.5 μg/dL. After adjustment for covariates, we found an inverse relationship between blood lead concentration and IQ score. Using a log-linear model, we found a 6.9 IQ point decrement [95% confidence interval (CI), 4.2–9.4] associated with an increase in concurrent blood lead levels from 2.4 to 30 μg/dL. The estimated IQ point decrements associated with an increase in blood lead from 2.4 to 10 μg/dL, 10 to 20 μg/dL, and 20 to 30 μg/dL were 3.9 (95% CI, 2.4–5.3), 1.9 (95% CI, 1.2–2.6), and 1.1 (95% CI, 0.7–1.5), respectively. For a given increase in blood lead, the lead-associated intellectual decrement for children with a maximal blood lead level < 7.5 μg/dL was significantly greater than that observed for those with a maximal blood lead level ≥7.5 μg/dL (p = 0.015). We conclude that environmental lead exposure in children who have maximal blood lead levels < 7.5 μg/dL is associated with intellectual deficits
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