Factors affecting survival to discharge in 53 cats diagnosed with uroabdomen: a single-centre retrospective analysis

Objectives The aim of this study was to assess outcomes in cats diagnosed with uroabdomen at a single referral centre. Methods Fifty-three cats diagnosed with uroabdomen at a veterinary teaching hospital were identified between June 2003 and September 2016. Data collected included signalment, presenting signs, aetiology, location of rupture, presence of concurrent injury, outcome of urine culture, presence of uroliths and packed cell volume (PCV)/creatinine/potassium levels at presentation. Cats managed medically and surgically were included, and the use of urinary catheters, cystotomy tubes and abdominal drains were recorded. It was determined if patients survived to discharge or if they were euthanased or died. Results Seventy-four percent (n = 39) of cats survived to discharge. Elevations in creatinine (P = 0.03) were shown to be significantly correlated with survival to discharge. Sex, age, location of rupture, presence of uroliths, outcome of urine culture, presence of concurrent injury, potassium at presentation and PCV at presentation were not associated with survival to discharge. There was no difference in survival between cats that were medically or surgically managed. Conclusions and relevance Cats that develop uroabdomen have a good chance of survival. Electrolyte and biochemistry values should be assessed at the time of presentation, in addition to the presence of concurrent injury

Feeling connected again: interventions that increase social identification reduce depression symptoms in community and clinical settings

Background: Clinical depression is often preceded by social withdrawal, however, limited research has examined whether depressive symptoms are alleviated by interventions that increase social contact. In particular, no research has investigated whether social identification (the sense of being part of a group) moderates the impact of social interventions

Continuous borehole optical televiewing reveals variable englacial debris concentrations at Khumbu Glacier, Nepal

Surface melting of High Mountain Asian debris-covered glaciers shapes the seasonal water supply to millions of people. This melt is strongly influenced by the spatially variable thickness of the supraglacial debris layer, which is itself partially controlled by englacial debris concentration and melt-out. Here, we present measurements of deep englacial debris concentrations from debris-covered Khumbu Glacier, Nepal, based on four borehole optical televiewer logs, each up to 150 m long. The mean borehole englacial debris content is ≤ 0.7% by volume in the glacier’s mid-to-upper ablation area, and increases to 6.4% by volume near the terminus. These concentrations are higher than those reported for other valley glaciers, although those measurements relate to discrete samples while our approach yields a continuous depth profile. The vertical distribution of englacial debris increases with depth, but is also highly variable, which will complicate predictions of future rates of surface melt and debris exhumation at such glaciers

Patient-reported outcome measures for acne: a mixed-methods validation study (acne PROMs).

OBJECTIVES: To examine the acceptability and validity of two patient-reported outcome measures (PROMs) for adult acne, comparing them to the validated Acne-specific Quality of Life (Acne-QoL) measure. DESIGN: Mixed-methods validation study. SETTING: Participants were recruited by (1) mail-out through primary care if they had ever consulted for acne and received a prescription for acne treatment within the last 6 months, (2) opportunistically in secondary care and (3) poster advertisement in community venues. PARTICIPANTS: 221 (204 quantitative and 17 qualitative) participants with acne, aged 18-50 years. OUTCOME MEASURES: Quantitative sub-study participants completed Acne-QoL, Skindex-16 and Comprehensive Acne Quality of Life Scale (CompAQ) at baseline, 24 hours and 6 weeks. Qualitative sub-study participants took part in cognitive think-aloud interviews, while completing the same measures. Transcribed audio recordings were analysed using inductive thematic analysis. RESULTS: Quantitative analyses suggested high internal consistency (Cronbach's alpha 0.74-0.96) and reliability (intraclass correlation coefficient values 0.88-0.97) for both questionnaires. Both scales showed floor effects on some subdomains. Skindex-16 and CompAQ showed good evidence of construct validity when compared with Acne-QoL with Spearman's correlation coefficients 0.54-0.81, and good repeatability over 24 hours.Qualitative data uncovered wide-ranging views regarding usability and acceptability. Interviewees held strong but differing views about layout, question/response wording, redundant/similar questions and guidance notes. Similarly, interviewees differed in perceptions of acceptability of the different scales, particularly on relatability of questions and emotive reactions to scales. CONCLUSIONS: All PROMs performed well in statistical analyses. No PROM showed superior usability and acceptability in the qualitative study. Any PROM should be acceptable for further research in adult acne but researchers should consider the different domains and whether they will measure only facial or facial and trunk acne before making a selection. A new PROM or further evaluation of novel PROMs may be beneficial

The Role of Differential Ablation and Dynamic Detachment in Driving Accelerating Mass Loss From a Debris-Covered Himalayan Glacier

Sustained mass loss from Himalayan glaciers is causing supraglacial debris to expand and thicken, with the expectation that thicker debris will suppress ablation and extend glacier longevity. However, debris-covered glaciers are losing mass at similar rates to clean-ice glaciers in High Mountain Asia. This rapid mass loss is attributed to the combined effects of; (a) low or reversed mass balance gradients across debris-covered glacier tongues, (b) differential ablation processes that locally enhance ablation within the debris-covered section of the glacier, for example, at ice cliffs and supraglacial ponds, and (c) a decrease in ice flux from the accumulation area in response to climatic warming. Adding meter-scale spatial variations in supraglacial debris thickness to an ice-flow model of Khumbu Glacier, Nepal, increased mass loss by 47% relative to simulations assuming a continuous debris layer over a 31-year period (1984–2015 CE) but overestimated the reduction in ice flux. Therefore, we investigated if simulating the effects of dynamic detachment of the upper active glacier from the debris-covered tongue would give a better representation of glacier behavior, as suggested by observations of change in glacier dynamics and structure indicating that this process occurred during the last 100 years. Observed glacier change was reproduced more reliably in simulations of the active, rather than entire, glacier extent, indicating that Khumbu Glacier has passed a dynamic tipping point by dynamically detaching from the heavily debris-covered tongue that contains 20% of the former ice volume

All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD

Variant CJD (vCJD) is an incurable, infectious human disease, likely arising from the consumption of BSE-contaminated meat products. Whilst the epidemic appears to be waning, there is much concern that vCJD infection may be perpetuated in humans by the transfusion of contaminated blood products. Since 2004, several cases of transfusion-associated vCJD transmission have been reported and linked to blood collected from pre-clinically affected donors. Using an animal model in which the disease manifested resembles that of humans affected with vCJD, we examined which blood components used in human medicine are likely to pose the greatest risk of transmitting vCJD via transfusion. We collected two full units of blood from BSE-infected donor animals during the pre-clinical phase of infection. Using methods employed by transfusion services we prepared red cell concentrates, plasma and platelets units (including leucoreduced equivalents). Following transfusion, we showed that all components contain sufficient levels of infectivity to cause disease following only a single transfusion and also that leucoreduction did not prevent disease transmission. These data suggest that all blood components are vectors for prion disease transmission, and highlight the importance of multiple control measures to minimise the risk of human to human transmission of vCJD by blood transfusion

Individualization as driving force of clustering phenomena in humans

One of the most intriguing dynamics in biological systems is the emergence of clustering, the self-organization into separated agglomerations of individuals. Several theories have been developed to explain clustering in, for instance, multi-cellular organisms, ant colonies, bee hives, flocks of birds, schools of fish, and animal herds. A persistent puzzle, however, is clustering of opinions in human populations. The puzzle is particularly pressing if opinions vary continuously, such as the degree to which citizens are in favor of or against a vaccination program. Existing opinion formation models suggest that "monoculture" is unavoidable in the long run, unless subsets of the population are perfectly separated from each other. Yet, social diversity is a robust empirical phenomenon, although perfect separation is hardly possible in an increasingly connected world. Considering randomness did not overcome the theoretical shortcomings so far. Small perturbations of individual opinions trigger social influence cascades that inevitably lead to monoculture, while larger noise disrupts opinion clusters and results in rampant individualism without any social structure. Our solution of the puzzle builds on recent empirical research, combining the integrative tendencies of social influence with the disintegrative effects of individualization. A key element of the new computational model is an adaptive kind of noise. We conduct simulation experiments to demonstrate that with this kind of noise, a third phase besides individualism and monoculture becomes possible, characterized by the formation of metastable clusters with diversity between and consensus within clusters. When clusters are small, individualization tendencies are too weak to prohibit a fusion of clusters. When clusters grow too large, however, individualization increases in strength, which promotes their splitting.Comment: 12 pages, 4 figure

When group members admit to being conformist: the role of relative intragroup status in conformity self-reports

Authors' draft; final version published in Personality and Social Psychology BulletinFive studies examined the hypothesis that people will strategically portray the self as being more group influenced the more junior they feel within the group. Among social psychologists (Study 1), ratings of self-conformity by group members were greater when the status of the participant was low than when it was high. These effects were replicated in Studies 2, 3, and 4 in which relative intragroup status was manipulated. In Study 3, the authors found junior group members described themselves as more conformist than senior members when they were addressing an ingroup audience, but when they were addressing an outgroup audience the effect disappeared. Furthermore, junior members (but not senior members) rated themselves as more conformist when they were led to believe their responses were public than when responses were private (Study 5). The discussion focuses on the strategic processes underlying low-status group members’ self-reports of group influence and the functional role of conformity in groups

Inhabiting infrastructure: exploring the interactional spaces of urban cycling

Contemporary cities are thick with infrastructure. In recognition of this fact a great deal of recent work within urban studies and urban geography has focused on transformations in the governance and ownership of infrastructural elements within cities. Less attention has been paid to the practices through which urban infrastructures are inhabited by urban dwellers. Yet in all sorts of ways infrastructures are realised through their use and inhabitation. This paper argues for the importance of attending to the ways that infrastructures are reinterpreted through use. Focusing on a case study of commuter cyclists in London, it explores the ways in which cyclists accommodate themselves to (and are in turn accommodated by) the infrastructural orderings of London’s streets. Confronted by the obduracy of a road infrastructure designed primarily for motorised traffic, cyclists show a diverse range of approaches to negotiating movement through the city on bikes. The paper describes how this negotiation can be understood in terms of the more or less skilful processes of navigation, rule following, rule making, and rule bending. This involves a polymorphous mix of practices, some common to driving, others to walking, and yet others unique to cycling. In conclusion, the paper suggests that transformations of infrastructures found within cities need to be understood as much through emergent changes between their elements, and that close attention to how infrastructures come to be inhabited offers productive avenues for thinking about ways to improve them