The Ursinus Weekly, January 15, 1934

Ursinus and Penn broadcast debate • Committee to study campus problems • G-burg trounces Chase five, 33-14 • Humorous comedy presented by Y • Phila. college club to confer Jan. 19-20 • Men\u27s Forensic Club arranges schedule • Frosh open season with Villanova tomorrow night • Women\u27s debating club accepts new members • Seniors consider programs for last class weekend • Y.M. discussion groups entertained at dinner • Hall Chemical Society to hear Dr. R. Sturgis • New method of conducting programs used by IRC • Faculty and students attend pol.-social science conference • Musical selections at Sunday night vespers • Soph hop scheduled for Tuesday, January 30 • Two dance dates granted at student act. council • New books acquired by college library • Short stories topic of English Club meeting • Councils make rules for freshman rushing periods • Program presented at Royersford by YW • Women\u27s student council plans revision of rules • List of fraternity and sorority membershttps://digitalcommons.ursinus.edu/weekly/2010/thumbnail.jp

The Ursinus Weekly, March 5, 1934

Excellent program for Founders\u27 Day • Jack Hart talks to Ursinus groups • Courtmen win one; lose two • Dean Kline guest of honor at Phila. dinner • Seniors plan dance and play Mar. 16-17 • Federal aid granted to needy college students • Men\u27s negative team debates on away trip • Prof. F. I. Sheeder speaks to York alumni members • Shaw-Bernard collection on display in college library • Matmen close season with 17-11 victory over Rutgers • Women debaters win and lose in dual contest with Western Maryland • Girls lose to Drexel and tie Beaver 20-20 • Frosh beat Drexel • Freshman debating team loses to North Coventry • The shine of dreams to be presented in Norristown • Girls second team wins over Drexel and Beaver • Shriner and Fircroft victors in dorm games • Future programs of campus organizations • College library acquires numerous new books • Belgium subject of discussion at IRC • Dr. and Mrs. Lentz hosts at dinner for captains • Dr. Philip Goepp addresses group of women students • Week of prayer speaker is guest of brotherhood • Miss Takacs presides at meeting of French Club • Quaker vesper service led by Shollenbergerhttps://digitalcommons.ursinus.edu/weekly/2015/thumbnail.jp

The Ursinus Weekly, October 9, 1933

Colleges will debate on NRA question this year • Frosh discussion groups are part of YM program • St. Joseph\u27s bow to Ursinus bears by 20-0 score in opening fray here • Interfraternity council amends bidding methods • Tennis tournament ends with Danehower as victor • New section Fair Ursinus planned for 1934 Ruby • James Wharton presides over pep meeting Friday • William Evans president of Hall Chemical Society • Freshmen football men prepare for first battle • Student council plans Old Timers\u27 Day dance • Interested students hear artist explain new course • U hockey team scores 6-2 victory over Drexel • Campus fraternity members • Dr. Sturgis chosen faculty adviser by Brotherhood • Activities council grants request for senior dance • Council treasurer to be elected at mass meeting • Y.M.-Y.W. doggie roast held Wednesday evening • Dr. E. B. White to coach women\u27s debating club • Int. rel. club to discuss important personalities • Women\u27s athletic assoc. makes awards to students • New methods to be used in Curtain Club tryouts • Miss Winder to address community mass meeting • Beta Sigma Lambda pledges new membershttps://digitalcommons.ursinus.edu/weekly/2000/thumbnail.jp

The Ursinus Weekly, May 22, 1933

Dr. John R. Murlin will speak at graduation • Council representatives chosen by men students • Grizzlies lose return game to Villanova • Athletic club to meet • Trackmen lose final dual track meet to St. Joseph\u27s • Beethoven\u27s Mass in D to be presented as oratorio • Complete program planned for commencement week • Grizzlies take fifth place in annual conference meet • Ursinus educators plan summer trip to Europe • Keen competition for new students among colleges • Senior girls to be guests of Woman\u27s Club at dinner • Ursinus Woman\u27s Club will give tea for senior girls • Attention 1933 alumni • Last Weekly on June 5 • Y.W. president will attend camp • Seniors plant class tree • Public speaking class has banquet at Franklin House • New members and officers selected by Debating Club • Y.W.C.A. holds council fire for freshmen and seniors • Parunak secures position in Bridgeport high school • Irving Sutin selected to head men\u27s Debating Club • Faculty will hold picnic • Girl\u27s tennis team meets defeat at Beaver College • Dr. Philip H. Goepp will sponsor student recital • International Relations Club hears Yen Lee and elects officers • Dean W. A. Kline honored at men\u27s faculty club dinner • Dr. James Anders to speak at Schwenkfeldian meeting • Election of officers held at Curtain Club meeting • Revision of women\u27s rules at WSGA mass meeting • College plates with scenes of campus will be on sale • English group elections • Dr. Uphaus lectures and holds student conferences • Seniors conduct worship program at vesper service • Ursinus cubs defeated by Villanova freshmen • Grizzly nine drops game to Eastern Pen by 4-3 scorehttps://digitalcommons.ursinus.edu/weekly/2057/thumbnail.jp

The Ursinus Weekly, November 6, 1933

Curtis institute artists to render evening concert • May Day pageant must be submitted by January 8 • Bears felled by G-burg Bullets, 12-13; frosh score 9-0 win at Farm School • College Glee Club sings at McAllister\u27s in Phila. • Faculty and students are entertained at YW tea • Fred Cardin, Indian lecturer, secured by Jr. advisory com. • Ditter Haynes to play for senior dance Nov. 11 • Ursinus harriers place second in conference meet • Soccermen tie Haverford but bow to the Bullets, 7-0 • Mrs. John Lentz plans to entertain freshman girls • Lecture by Dr. J. Mauchly to Hall Chemical Society • Y.M. to be guests of Y.W. at armistice day program • Father\u27s Day banquet after Muhlenberg game • Women\u27s dorm committee to sponsor tea and bazaar • Ye famed tugge-of-warre sees sophs victors; Parson Mitchell drenched in watery battle • English Club plans discussion of modern theatre tonight • Mathematics group enjoys games and speeches at meeting • Big-little sisters unite in celebrating Halloween • Y.M.C.A. chorus makes tentative plans for year • Hist.-social science group elects Wm. O\u27Donnell pres. • Pep rally talks by pop Hendricks and Brownback • Mr. Pettit speaks to Y on topic of religion • Glenside Quarterly Club to witness football game • Curtain Club may present production in December • Thank you doctor to be presented November 18 • Church conference held at Ursinus November 4 • Political impersonations at women\u27s debating club • Brotherhood discusses prayer at meeting • Roxborough M. E. Church to hear Ursinus Glee Club • New press box will welcome visiting scribes hereafter • Wm. Tempest leads vespers in appreciation program • Representatives attend YW cabinet conferencehttps://digitalcommons.ursinus.edu/weekly/2004/thumbnail.jp

The Lantern Vol. 3, No. 1, December 1934

• Magic Words • The Old Trappe Church • The Light of Life • Edwin Markham: Impressions • Increment (A Christmas Thought) • Our Christmas • What Price Forgetting? • Autumn • The Old Parson • Zacharias Ursinus • Inspiration • A Scrap-Book of Memories • A Campus Saunterhttps://digitalcommons.ursinus.edu/lantern/1004/thumbnail.jp

The Lantern Vol. 3, No. 2, March 1935

• Puppets of Propaganda • Reluctance • Reflections From My Diary • Reverie • Bash Turner Enters the Limelight • The College Students\u27 Obligation • The Schwenkfelders • Love\u27s Desire • Verse • On the Squirt of a Grapefruit • Pioneers! • Whither Fraternities? • Mary Peters: A Book Review • Different as Night and Day • Ode to an Alley Cathttps://digitalcommons.ursinus.edu/lantern/1005/thumbnail.jp

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society