noteEd - A web-based lecture capture system

Electronic capture and playback of lectures has long been the aim of many academic projects. Synote is an application developed under MACFoB (Multimedia Annotation and Community Folksonomy Building) project to synchronise the playback of lecture materials. However, Synote provides no functionality to capture such multimedia. This project involves the creation of a system called noteEd, which will capture a range of multimedia from lectures and make them available to Synote. This report describes the evolution of the noteEd project throughout the design and implementation of the proposed system. The performance of the system was checked in a user acceptance test with the customer, which is discussed after screenshots of our solution. Finally, the project management is presented containing a final project evaluation

The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs

The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen (O2) supply during acute normovolemic anemia has not been investigated so far. Methods: Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration (Hbcrit). Hbcrit was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body O2-consumption (VO2). The hemodilution protocol was randomly performed with either Tetrastarch (6% HES 130/0.4, TS-group, n=9), Gelatin (3.5% urea-crosslinked polygeline, GEL-group, n=9), Hetastarch (6% HES 450/0.7, HS-group, n=9) or Ringer's solution (RS-group, n=9). The primary endpoint was the dimension of Hbcrit, secondary endpoints were parameters of central hemodynamics, O2-transport and tissue oxygenation. Results: In each animal, normovolemia was maintained throughout the protocol. Hbcrit was met at 3.7+/-0.6 g/dl (RS), 3.0+/-0.6 g/dl (HS P<0.05 vs. RS), 2.7+/-0.6 g/dl (GEL, P<0.05 vs. RS) and 2.1+/-0.4 g/dl (TS, P<0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure (paO2), O2-extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual Hbcrit. Conclusions: The choice of the intravenous (i.v) fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation Tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function

Decision Making in Virtual Worlds: An Experimental Test of Altruism, Fairness and Presence

Virtual worlds are gaining in popularity and are proposed as a test laboratory for the real world. Inthese virtual worlds users act via their avatars and make decisions for them. In this paper, we analyzethe decision making in virtual worlds in an experiment conducted in a virtual world, as well as in thereal world over the internet, for the same set of subjects. For this purpose, we develop hypotheses fordecision making in the context of a classic economic experiment (the Dictator Game). We find similardecisions in the virtual and the real world with respect to sharing. Altruism has a significant influencein the real world setting but not in the virtual world; fairness is insignificant in both settings. Weidentify the feeling of presence in one’s avatar and potential satiation effects as factors that influencedecisions regarding the allocation of resources in the virtual world

GenomeRNAi: a database for cell-based RNAi phenotypes

RNA interference (RNAi) has emerged as a powerful tool to generate loss-of-function phenotypes in a variety of organisms. Combined with the sequence information of almost completely annotated genomes, RNAi technologies have opened new avenues to conduct systematic genetic screens for every annotated gene in the genome. As increasing large datasets of RNAi-induced phenotypes become available, an important challenge remains the systematic integration and annotation of functional information. Genome-wide RNAi screens have been performed both in Caenorhabditis elegans and Drosophila for a variety of phenotypes and several RNAi libraries have become available to assess phenotypes for almost every gene in the genome. These screens were performed using different types of assays from visible phenotypes to focused transcriptional readouts and provide a rich data source for functional annotation across different species. The GenomeRNAi database provides access to published RNAi phenotypes obtained from cell-based screens and maps them to their genomic locus, including possible non-specific regions. The database also gives access to sequence information of RNAi probes used in various screens. It can be searched by phenotype, by gene, by RNAi probe or by sequence and is accessible a

Land use and soil development in Southern chile: Effects on physical properties

Different physical properties of volcanic ash soils were investigated along a transect of 120 km from the western slope of the Central Cordilleras (40°20’S, 72°06’W) to the eastern slope of the Costal Cordillera (39°39’S, 73°11’W) in southern Chile with respect to the degree of soil development (Arenosol versus Andosol stage; Arenosol: young volcanic ash soil, free of clay, tephric properties, Andosol: older volcanic soil, clayey). The Andosols show a higher total pore volume and a higher field capacity, especially due to an increase in fine pores, than the Arenosols. Furthermore, the precompression stress (Pc) as a parameter for the mechanical soil strength is higher for Andosols despite of a lower bulk density. A land use (cropland, meadow, forest) dependent variation of the investigated parameters was less distinct for Andosols. A reduction of macropores and saturated hydraulic conductivity (ks) due to agriculture could be determined in the field, but in general the values are still on a high level with ks-values >100 cm d-1. However, at higher stresses using an oedometer test the ks-values of the Andosols are highly negatively affected with values <10 cm d-1. Aggregation is of major importance for soil stability of Andosols, whereas a homogenization of soil structure will lead to a distinct decrease of Pc of approx. 50%.DFG/HO 911/45-1DFG/BA 1359/12-

Geographies of the ageing-migration nexus: an introduction

This special section builds on previous scholarship on geographies of ageing, and on relational and transnational approaches to age and migration, to assert the significance of the ageing-migration nexus in human geography. Our primary goal is to examine the intricate relationships between ageing, migration, space and place. By bringing empirical research on ageing and migration into dialogue with existing conceptual work within geography, we also aim to critically contribute to current debates in both areas. The contributors explore a wide range of migration processes and experiences through an intersectional lens, and demonstrate the importance of a diverse set of epistemological and methodological approaches to explore the spatialities of the ageing–migration nexus. Key dimensions examined include, but are not limited to, the spaces and places of ageing and migration, the multi-scalar nature of the geographies of the ageing–migration nexus, their (im)mobilities, fluid boundaries, and emotional geographies

Free-Flap Reconstruction in Early-Stage Squamous Cell Carcinoma of the Oral Cavity : A Prospective Monocentric Trial to Evaluate Oncological Outcome and Quality of Life

Surgery is generally accepted as standard treatment in oral cancer, but the reconstructive procedures remain a matter of debate. The aim of this study was to evaluate oncological outcome and quality of life following surgical resection and free-flap reconstruction in patients with early oral squamous cell carcinoma. The presented trial was performed as a prospective, single-center observation study. Inclusion criteria were primary surgery in early-stage oral squamous cell carcinoma with free-flap reconstruction. Endpoints were overall and progression-free survival and quality of life up to 24 months after surgery. Twenty-six patients were included. Overall survival was 100% and progression-free survival was 92.3% in a maximum follow-up time of 21 months. Global quality of life showed no significant alteration after surgery. Patients reported a significant reduction in pain (p = 0.048) and a decreasing impairment of speech one year after surgery (p = 0.021). Free-flap reconstruction is a safe procedure that results in excellent oncological outcome and quality of life. Functional outcome is of high relevance in early-stage tumors of the head and neck and may mostly be affected by reconstructive procedures. Therefore, a prospective evaluation to explore success and the effects of surgical therapy is highly warranted

Surgical Treatment of Carcinomas of the Oral Minor Salivary Glands : Oncological Outcome in Dependence of Tumor Entity and Therapeutic Strategies

The aim of this study was to analyze the clinical outcomes of three types of minor salivary gland carcinomas (adenoid-cystic carcinomas (ACC), adeno carcinomas not otherwise specified (AC-NOS), and mucoepidermoid carcinomas (MEC)) after primary surgical therapy. A retrospective cohort study was designed and patients with cancer of the minor oral salivary glands treated in our department in the years 2011 to 2022 were included. Clinicopathological data were evaluated to compare overall survival and progression-free survival between the entities. Eighty-one patients were included. The rates of cervical metastases were 38.9% for ACC, 25% for MEC, and 9.1% for AC-NOS. ACC exhibited significantly higher rates of local and systemic disease recurrence (p = 0.02), and the presence of neck node metastases was confirmed as an independent prognostic factor for progressionfree survival (p = 0.014). Treatment success in terms of oncological outcome varied significantly between the different entities and implies different treatment regimens for each tumor entity

Full-Thickness Tumor Resection of Oral Cancer Involving the Facial Skin—Microsurgical Reconstruction of Extensive Defects after Radical Treatment of Advanced Squamous Cell Carcinoma

Advanced tumors of the head and neck are challenging for the treatment specialist due to the need to synergize oncological and functional requirements. Free flap reconstruction has been established as the standard of care for defects following tumor resection. However, depending on the affected anatomic subsite, advanced tumors may impose specific difficulties regarding reconstruction, especially when full-thickness resection is required. This study aimed to evaluate reconstructive strategies and oncological outcomes in patients with full-thickness resection of the oral cavity. A total of 33 patients with extensive defects due to squamous cell carcinoma of the oral cavity were identified. Indications, reconstructive procedures, and clinical outcome were evaluated. Thirty-two patients (97%) presented locally advanced tumors (T3/T4). Complete tumor resection was achieved in 26 patients (78.8%). The anterolateral thigh flap was the most frequently used flap (47.1%), and the primary flap success rate was 84.8%. The cohort demonstrated a good local control rate and moderate overall and progression-free survival rates. Most patients regained full competence regarding oral alimentation and speech. Full-thickness tumor resections of the head and neck area may be necessary due to advanced tumors in critical anatomic areas. In many cases, radical surgical treatment leads to good oncological results. Free flap reconstruction has been shown to be a suitable option for extensive defects in aesthetically challenging regions