Phase II study of S-1, a novel oral fluoropyrimidine derivative, in patients with metastatic colorectal carcinoma

This study set out to evaluate, in patients with metastatic colorectal carcinoma, the efficacy and toxicity of S-1, which contains tegafur, 5-chloro-2,4-dihydroxypyridine (CDHP) and potassium oxonate, based on a biochemical modulation of 5-fluorouracil (5-FU) targeted at inhibition of dihydropyrimidine dehydrogenase (DPD). Sixty-three patients with measurable metastatic colorectal carcinoma were enrolled into the study. None of the patients had received prior chemotherapy except for adjuvant setting. S-1 was administered orally twice daily at a standard dose of 80 mg m–2day–1for 28 days followed by a 14-day rest. This agent is continued until disease progression, unaccepted toxicity, or patient refusal. Twenty-two (35%) of the 62 eligible patients achieved PR with a 95% confidence interval of 25–48%. Five of the 10 patients with a history of adjuvant chemotherapy achieved partial remission. The median survival time was 12 months. Major adverse reactions included myelosuppressive and gastrointestinal toxicities, though their incidence of grade 3 or 4 being 13% in neutropenia and less than 10% in the others. None of the 53 patients treated as outpatients required hospitalization due to adverse reactions: These results suggest that S-1 achieves similar responses to those of infusional 5-FU plus leucovorin and shows the potential of another biochemical modulation with easily manageable toxicity. © 2000 Cancer Research Campaig

Anomalous Stability of nu=1 Bilayer Quantum Hall State

We have studied the fractional and integer quantum Hall (QH) effects in a high-mobility double-layer two-dimensional electron system. We have compared the "stability" of the QH state in balanced and unbalanced double quantum wells. The behavior of the n=1 QH state is found to be strikingly different from all others. It is anomalously stable, though all other states decay, as the electron density is made unbalanced between the two quantum wells. We interpret the peculiar features of the nu=1 state as the consequences of the interlayer quantum coherence developed spontaneously on the basis of the composite-boson picture.Comment: 5 pages, 6 figure

Exploring the Thermodynamics of a Universal Fermi Gas

From sand piles to electrons in metals, one of the greatest challenges in modern physics is to understand the behavior of an ensemble of strongly interacting particles. A class of quantum many-body systems such as neutron matter and cold Fermi gases share the same universal thermodynamic properties when interactions reach the maximum effective value allowed by quantum mechanics, the so-called unitary limit [1,2]. It is then possible to simulate some astrophysical phenomena inside the highly controlled environment of an atomic physics laboratory. Previous work on the thermodynamics of a two-component Fermi gas led to thermodynamic quantities averaged over the trap [3-5], making it difficult to compare with many-body theories developed for uniform gases. Here we develop a general method that provides for the first time the equation of state of a uniform gas, as well as a detailed comparison with existing theories [6,14]. The precision of our equation of state leads to new physical insights on the unitary gas. For the unpolarized gas, we prove that the low-temperature thermodynamics of the strongly interacting normal phase is well described by Fermi liquid theory and we localize the superfluid transition. For a spin-polarized system, our equation of state at zero temperature has a 2% accuracy and it extends the work of [15] on the phase diagram to a new regime of precision. We show in particular that, despite strong correlations, the normal phase behaves as a mixture of two ideal gases: a Fermi gas of bare majority atoms and a non-interacting gas of dressed quasi-particles, the fermionic polarons [10,16-18].Comment: 8 pages, 5 figure

Measurement of the cosmic-ray antiproton spectrum at solar minimum with a long-duration balloon flight over Antarctica

The energy spectrum of cosmic-ray antiprotons from 0.17 to 3.5 GeV has been measured using 7886 antiprotons detected by BESS-Polar II during a long-duration flight over Antarctica near solar minimum in December 2007 and January 2008. This shows good consistency with secondary antiproton calculations. Cosmologically primary antiprotons have been investigated by comparing measured and calculated antiproton spectra. BESS-Polar II data show no evidence of primary antiprotons from evaporation of primordial black holes.Comment: 4 pages, 4 figures, submitted to Physical Review Letter

Interlayer Coherence in the ν=1\nu=1 and ν=2\nu=2 Bilayer Quantum Hall States

We have measured the Hall-plateau width and the activation energy of the bilayer quantum Hall (BLQH) states at the Landau-level filling factor $\nu=1$ and 2 by tilting the sample and simultaneously changing the electron density in each quantum well. The phase transition between the commensurate and incommensurate states are confirmed at $\nu =1$ and discovered at $\nu =2$. In particular, three different $\nu =2$ BLQH states are identified; the compound state, the coherent commensurate state, and the coherent incommensurate state.Comment: 4 pages including 5 figure

Phase Transition in \nu=2 Bilayer Quantum Hall State

The Hall-plateau width and the activation energy were measured in the bilayer quantum Hall state at filling factor \nu=2, 1 and 2/3, by changing the total electron density and the density ratio in the two quantum wells. Their behavior are remarkably different from one to another. The \nu=1 state is found stable over all measured range of the density difference, while the \nu=2/3$ state is stable only around the balanced point. The \nu=2 state, on the other hand, shows a phase transition between these two types of the states as the electron density is changed.Comment: 5 pages including figures, RevTe

Healthy Campus Trial: A multiphase optimization strategy (MOST) fully factorial trial to optimize the smartphone cognitive behavioral therapy (CBT) app for mental health promotion among university students: Study protocol for a randomized controlled trial

This is the final version. Available from the publisher via the DOI in this record.After the publication of the primary findings, the de-identified and completely anonymized individual participant-level dataset will be posted on the UMIN-ICDR website (http://www.umin.ac.jp/icdr/index-j.html) so that it can be accessed by qualified researchers.Background: Youth in general and college life in particular are characterized by new educational, vocational, and interpersonal challenges, opportunities, and substantial stress. It is estimated that 30-50% of university students meet criteria for some mental disorder, especially depression, in any given year. The university has traditionally provided many channels to promote students' mental health, but until now only a minority have sought such help, possibly owing to lack of time and/or to stigma related to mental illness. Smartphone-delivered cognitive behavioral therapy (CBT) shows promise for its accessibility and effectiveness. However, its most effective components and for whom it is more (or less) effective are not known. Methods/design: Based on the multiphase optimization strategy framework, this study is a parallel-group, multicenter, open, fully factorial trial examining five smartphone-delivered CBT components (self-monitoring, cognitive restructuring, behavioral activation, assertion training, and problem solving) among university students with elevated distress, defined as scoring 5 or more on the Patient Health Questionnaire-9 (PHQ-9). The primary outcome is change in PHQ-9 scores from baseline to week 8. We will estimate specific efficacy of the five components and their interactions through the mixed-effects repeated-measures analysis and propose the most effective and efficacious combinations of components. Effect modification by selected baseline characteristics will be examined in exploratory analyses. Discussion: The highly efficient experimental design will allow identification of the most effective components and the most efficient combinations thereof among the five components of smartphone CBT for university students. Pragmatically, the findings will help make the most efficacious CBT package accessible to a large number of distressed university students at reduced cost; theoretically, they will shed light on the underlying mechanisms of CBT and help further advance CBT for depression

Feynman diagrams versus Fermi-gas Feynman emulator

Precise understanding of strongly interacting fermions, from electrons in modern materials to nuclear matter, presents a major goal in modern physics. However, the theoretical description of interacting Fermi systems is usually plagued by the intricate quantum statistics at play. Here we present a cross-validation between a new theoretical approach, Bold Diagrammatic Monte Carlo (BDMC), and precision experiments on ultra-cold atoms. Specifically, we compute and measure with unprecedented accuracy the normal-state equation of state of the unitary gas, a prototypical example of a strongly correlated fermionic system. Excellent agreement demonstrates that a series of Feynman diagrams can be controllably resummed in a non-perturbative regime using BDMC. This opens the door to the solution of some of the most challenging problems across many areas of physics