The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer

Current focus in colorectal cancer management is on reducing overall mortality by increasing the number of early stage cancers diagnosed and treated with curative intent. Despite the success of screening programmes in down-staging colorectal cancer, interval cancer rates are substantial and other strategies are desirable. Sporadic colorectal cancer is largely associated with lifestyle factors including diet. Polyphenols are phytochemicals ingested as part of a normal diet which are abundant in plant foods including fruits/berries and vegetables. These may exert their anti-carcinogenic effects via the modulation of inflammatory pathways. Key signal transduction pathways are fundamental to the association of inflammation and disease progression including those mediated by NF-κB and STAT, PI3K and COX. Our aim was to examine the evidence for the effect of dietary polyphenols intake on tumour and host inflammatory responses to determine if polyphenols may be effective as part of a dietary intervention. There is good epidemiological evidence of a reduction in colorectal cancer risk from case-control and cohort studies assessing polyphenol intake. It would be premature to suggest a major public health intervention to promote their consumption however, dietary change is safe and feasible, emphasising the need for further investigation of polyphenols and colorectal cancer risk

Developing a Phosphorus Fertilizer Training Program for Golf Course Personnel

A new Extension program has been developed in Minnesota to train golf course personnel on managing phosphorus inputs in response to recently passed legislation restricting the use of P fertilizers applied to turfgrass. This article introduces the P legislation passed in Minnesota, describes the curriculum, and discusses survey responses from golf course personnel who have participated in the program. The data presented indicate that respondents found the program either useful or very useful with respect to the day-to-day management of P fertilizers applied to turf

Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer

The aim of the present study was to compare the clinical utility of two measures of the inflammatory cell infiltrate - a H&E-based assessment of the generalised inflammatory cell infiltrate (the Klintrup-Mäkinen (KM) grade), and an immunohistochemistry-based assessment of combined CD3+ and CD8+ T-cell density (the “Immunoscore”), in conjunction with assessment of the tumor stroma percentage (TSP) in patients undergoing resection of stage I-III colorectal cancer (CRC). 246 patients were identified from a prospectively maintained database of CRC resections in a single surgical unit. Assessment of KM grade and TSP was performed using full H&E sections. CD3+ and CD8+ T-cell density was assessed on full sections and the Immunoscore calculated. KM grade and Immunoscore were strongly associated (P<0.001). KM grade stratified cancer-specific survival (CSS) from 88% to 66% (P=0.002) and Immunoscore from 93% to 61% (P<0.001). Immunoscore further stratified survival of patients independent of KM grade from 94% (high KM, Im4) to 60% (low KM, Im0/1). Furthermore, TSP stratified survival of patients with a weak inflammatory cell infiltrate (low KM: from 75% to 47%; Im0/1: from 71% to 38%, both P<0.001) but not those with a strong inflammatory infiltrate. On multivariate analysis, only Immunoscore (HR 0.44, P<0.001) and TSP (HR 2.04, P<0.001) were independently associated with CSS. These results suggest that the prognostic value of an immunohistochemistry-based assessment of the inflammatory cell infiltrate is superior to H&E-based assessment in patients undergoing resection of stage I-III CRC. Furthermore, assessment of the tumor-associated stroma, using TSP, further improves prediction of outcome

Precise charm to strange mass ratio and light quark masses from full lattice QCD

By using a single formalism to handle charm, strange and light valence quarks in full lattice QCD for the first time, we are able to determine ratios of quark masses to 1%. For $m_c/m_s$ we obtain 11.85(16), an order of magnitude more precise than the current PDG average. Combined with 1% determinations of the charm quark mass now possible this gives $\bar{m}_s(2{\rm GeV}) =$ 92.4(1.5) MeV. The MILC result for $m_s/m_l = 27.2(3)$ yields $\bar{m}_l(2{\rm GeV})$ = 3.40(7) MeV for the average of $u$ and $d$ quark masses.Comment: 4 pages, 2 figures. Version accepted by Physical Review Letters. Changes include modifying the title, using the MILC value for m_s/m_l which changes slightly the resulting up and down quark masses and their average, adding some references and making other small adjustments to the text for space reasons

Disaggregating Lone-actor Grievance-fuelled Violence: Comparing Lone-actor Terrorists and Mass Murderers

Research suggests that lone-actor terrorists and mass murderers may be better conceptualized as lone-actor grievance-fueled violence (LAGFV) offenders, rather than as distinct types. The present study sought to examine the extent to which these offenders could (or could not) be disaggregated along dimensions relevant to the threat assessment of both. Drawing on a Risk Analysis Framework (RAF), the offending process was theorized as interactions among propensity, situation, preparatory, leakage and network indicators. We analyzed a dataset of 183 U.S. offenders, including sixty-eight lone-actor terrorists and 115 solo mass murderers. Cluster analysis identified profiles within each of the components: propensity (stable, criminal, unstable), situation (low stress, high stress (social), high stress (interpersonal), preparatory (fixated, novel aggression, equipped, clandestine, predatory, preparatory), leakage (high leakage, low leakage), and network (lone, associated, connected). Bi-variate analysis examined the extent to which the profiles classified offenders previously labeled as lone-actor terrorists or mass murderers. The results suggest that while significant differences may exist at the periphery of these dimensions, offenders previously classified as lone-actor terrorists or mass murderers occupy a noteworthy shared space. Moreover, no profile classifies a single “type” of offender exclusively. Lastly, we propose a dynamic, interactional model of LAGFV and discuss the implications of these findings for the threat assessment and management of LAGFV offenders

Sediment Sorting and Rounding in a Basaltic Glacio-Fluvio-Aeolian Environment: hrisjkull Glacier, Iceland

Sediments and sedimentary rocks preserve a rich history of environment and climate. Identifying these signals requires an understanding of the physical and chemical processes that have affected sedimentary deposits [1]. Such processes include sorting and rounding during transport and chemical alteration through weathering and diagenesis. Although these processes have long been studied in quartz-dominated sedimentary systems [2], a lack of studies of basaltic sedimentary systems limits our interpretations of the environment and climate where mafic source rocks dominate, such as on Mars [3,4]. As part of the SAND-E: Semi-Autonomous Navigation for Detrital Environments project [5], which uses robotic operations to examine physical and chemical changes to sediments in basaltic glacio-fluvialaeolian environments, this research studies changes in sorting and rounding of fluvial-aeolian sediments along a glacier-proximal-to-glacier-distal transect in the outwash-plain of the risjkull glacier in SW Iceland (Fig. 1

Using XRD to Characterize Sediment Sorting in a Mars Analog Glacio-Fluvio-Eolian Basaltic Sedimentary System in Iceland

The martian surface has a primarily basaltic composition and is dominated by sedimentary deposits. Ancient layered sedimentary rocks have been identified across the planet from orbit, have been studied in situ by the Mars Exploration Rovers and the Mars Science Laboratory rover, and will be studied by the Mars 2020 rover. These ancient sedimentary rocks were deposited in fluvial, lacustrine, and eolian environments during a warmer and wetter era on Mars. It is important to study the composition of sediments in Mars analog environments to characterize how minerals in basaltic sedimentary systems are sorted and/or aqueously altered. This information can help us better interpret sedimentary processes from similar deposits on Mars and derive information about the igneous source rocks. Sediment sorting has been studied extensively on Earth, but not typically in basaltic environments. Previous work has addressed sorting of basaltic sediments through experimental techniques and in modern eolian basaltic systems and aqueous alteration in subglacial and proglacial environments. We add to this body of research by studying sediment sorting and aqueous alteration in a glacio-fluvio-eolian basaltic system in southwest Iceland