Conflict, cooperation or competition in the Caspian Sea region:A critical review of the New Great Game paradigm

This article critically reviews the New Great Game image of the Caspian Sea region and the assumptions, concepts, and mechanisms (revolving around actors, aims, and motivations) this image is based on. More specifically, this review essay answers the following questions: How does the academic literature interpret the impact of competition between great powers on social, political and economic developments in the Caspian Sea region? Which actors are presented as the dominant players? The essay also introduces the existing criticism of the New Great Game concept and alternatives to it that have already been put forward. By identifying the gaps and limits of existing scholarship, this article offers new avenues for alternative theoretical and empirical interpretations. More specifically, this article argues that the New Great Game literature promotes unsystematic and shallow discussion as it ignores and misunderstands historical, material, political, economic, and normative differences in the Caspian Sea region. Within this discussion, actors, interests, identities, social contexts, and principles are taken to be fixed, i.e. not prone to change or to any sort of adjustmen

The Nineteenth-Century World of Turkic Dictionaries: An Overview

The author creates a bibliographic picture of the various Turkic-language dictionaries from the eleventh to the end of the nineteenth centuries, in various languages, and describes their structure. He then focuses specifically on printed Turkic dictionaries of the nineteenth century, discussing their historical context and a statistical survey that he conducted. A number of these dictionaries have been digitized; he examines some sites where they are accessible. In the appendix is a list of the dictionaries that he found in the course of his research

Genetic risk converges on regulatory networks mediating early type 2 diabetes.

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is characterized by dysfunction of insulin-producing pancreatic islet β cells1,2. T2D genome-wide association studies (GWAS) have identified hundreds of signals in non-coding and β cell regulatory genomic regions, but deciphering their biological mechanisms remains challenging3–5. Here, to identify early disease-driving events, we performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors. By integrating diverse modalities, we show that early-stage T2D is characterized by β cell-intrinsic defects that can be proportioned into gene regulatory modules with enrichment in signals of genetic risk. After identifying the β cell hub gene and transcription factor RFX6 within one such module, we demonstrated multiple layers of genetic risk that converge on an RFX6-mediated network to reduce insulin secretion by β cells. RFX6 perturbation in primary human islet cells alters β cell chromatin architecture at regions enriched for T2D GWAS signals, and population-scale genetic analyses causally link genetically predicted reduced RFX6 expression with increased T2D risk. Understanding the molecular mechanisms of complex, systemic diseases necessitates integration of signals from multiple molecules, cells, organs and individuals, and thus we anticipate that this approach will be a useful template to identify and validate key regulatory networks and master hub genes for other diseases or traits using GWAS data