Susanne Popp / Johanna Forster (Hrsg.): Curriculum Weltgeschichte. Globale Zugänge für den Geschichtsunterricht. Schwalbach: Wochenschau-Verlag 2003 (312 S.) […] [Sammelrezension]

Rezension von: 1. Susanne Popp / Johanna Forster (Hrsg.): Curriculum Weltgeschichte. Globale Zugänge für den Geschichtsunterricht. Schwalbach: Wochenschau-Verlag 2003 (312 S.; ISBN 3-87920-077-7; 28,00 EUR); 2. Klaus Seitz: Bildung in der Weltgesellschaft. Gesellschaftstheoretische Grundlagen Globalen Lernens. Frankfurt a.M.: Brandes & Apsel 2002 (492 S.; ISBN 3-86099-758-0; 29,90 EUR)

Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease

Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations

Walburga Hoff / Elke Kleinau / Pia Schmid (Hrsg.): Gender-Geschichte/n. Ergebnisse bildungshistorischer Frauen- und Geschlechterforschung. Köln/Weimar/Wien: Böhlau 2008 (313 S.) [Rezension]

Rezension von: Walburga Hoff / Elke Kleinau / Pia Schmid (Hrsg.): Gender-Geschichte/n. Ergebnisse bildungshistorischer Frauen- und Geschlechterforschung. Köln/Weimar/Wien: Böhlau 2008 (313 S.; ISBN 978-3-412-20247-7; 39,90 EUR)

Anja Belemann-Smit: Wenn schnöde Wollust dich erfüllt … Geschlechtsspezifische Aspekte in der Anti-Onanie-Debatte des 18. Jahrhunderts. Frankfurt a.M.: Peter Lang 2003 (233 S.) […] [Sammelrezension]

Rezension von: 1. Anja Belemann-Smit: Wenn schnöde Wollust dich erfüllt … Geschlechtsspezifische Aspekte in der Anti-Onanie-Debatte des 18. Jahrhunderts. Frankfurt a.M.: Peter Lang 2003 (233 S.; ISBN 3-631-50429-2; 37,80 EUR); 2. Nicole Lippki: Integration und Differenz der Geschlechter. Ihre Entdeckung in didaktischer Absicht zu Beginn des Zeitalters der Aufklärung. Rekonstruktion an Samuel Richardsons Erziehungsroman Pamela Frankfurt a.M.: Peter Lang 2003 (388 S.; ISBN 3-631-50598-1; 50,10 EUR)

Retinoic acid prevents experimental Cushing syndrome

Cushing syndrome is caused by an excess of adrenocorticotropic hormone (ACTH) production by neuroendocrine tumors, which subsequently results in chronic glucocorticoid excess. We found that retinoic acid inhibits the transcriptional activity of AP-1 and the orphan receptors Nur77 and Nurr1 in ACTH-secreting tumor cells. Retinoic acid treatment resulted in reduced pro-opiomelanocortin transcription and ACTH production. ACTH inhibition was also observed in human pituitary ACTH-secreting tumor cells and a small-cell lung cancer cell line, but not in normal cells. This correlated with the expression of the orphan receptor COUP-TFI, which was found in normal corticotrophs but not in pituitary Cushing tumors. COUP-TFI expression in ACTH-secreting tumor cells blocked retinoic acid action. Retinoic acid also inhibited cell proliferation and, after prolonged treatment, increased caspase-3 activity and induced cell death in ACTH-secreting cells. In adrenal cortex cells, retinoic acid inhibited corticosterone production and cell proliferation. The antiproliferative action and the inhibition of ACTH and corticosterone produced by retinoic acid were confirmed in vivo in experimental ACTH-secreting tumors in nude mice. Thus, we conclude that the effects of retinoic acid combine in vivo to reverse the endocrine alterations and symptoms observed in experimental Cushing syndrome

Outcomes of SARS-CoV-2 Infections in Patients With Neurodegenerative Diseases in the LEOSS Cohort

The impact of preexisting neurodegenerative diseases on superimposed SARS-CoV-2 infections remains controversial. Here we examined the course and outcome of SARS-CoV-2 infections in patients affected by Parkinson's disease (PD) or dementia compared to matched controls without neurodegenerative diseases in the LEOSS (Lean European Open Survey on SARS-CoV-2-infected patients) cohort, a large-scale prospective multicenter cohort study..