AstroGrid Virtual Observatory Access to Large Scale Surveys: The IPHAS Galactic Plane Survey - a Science Driven Example

Original paper can be found at: http://aspbooks.org/a/volumes Copyright Astronomical Society of the PacificThis paper describes how the IPHAS galactic plane survey data products are being made available utilizing the AstroGrid Virtual Observatory system (http://www.astrogrid.org). This is enabling the analysis of the large pipeline-processed IPHAS data products, both images and catalogs. Note is made of how the AstroGrid system is being used by the astronomer, for instance in the use of workflows to automate certain routine analysis operations, such as generating lists of candidate emission line stars, based on database queries of the IPHAS catalog data. Specific science use-case examples are given that benefit from the powerful VO access to the IPHAS data, including use of emission line stars as probes of galactic structure

Five WC9 stars discovered in the AAO/UKST Ha survey

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Detection of new planetary nebulae by IPHAS, the Hα survey of the North Galactic plane

Copyright 2005 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of PhysicsIPHAS is an ongoing Hα imaging survey of the North Galactic plane. When completed, it is expected to discover several hundred new Galactic planetary nebulae, in addition to a huge number of Hα emitters. We present here the project, the methods used to search for compact and extended ionized nebulae, and some preliminary results about the ∼100 new candidate planetary nebulae identified so far

The AAO/UKST SuperCOSMOS Ha survey

The definitive version is available at www.blackwell-synergy.com. Copyright Blackwell Publishing DOI : 10.1111/j.1365-2966.2005.09350.xThe UK Schmidt Telescope (UKST) of the Anglo-Australian Observatory completed a narrow-band H plus [NII] 6548, 6584°A survey of the Southern Galactic Plane and Magellanic Clouds in late 2003. The survey, which was the last UKST wide-field pho- tographic survey, and the only one undertaken in a narrow band, is now an on-line digital data product of the Wide-Field Astronomy Unit of the Royal Observatory Ed- inburgh (ROE). The survey utilised a high specification, monolithic H interference band-pass filter of exceptional quality. In conjunction with the fine grained Tech-Pan film as a detector it has produced a survey with a powerful combination of area cover- age (4000 square degrees), resolution (∼1 arcsecond) and sensitivity (≤5 Rayleighs), reaching a depth for continuum point sources of R ≃ 20.5. The main survey consists of 233 individual fields on a grid of centres separated by 4◦ at declinations below +2◦ and covers a swathe approximately 20◦ wide about the Southern Galactic Plane. The original survey films were scanned by the SuperCOSMOS measuring machine at the Royal Observatory, Edinburgh to provide the on-line digital atlas called the SuperCOSMOS H Survey (SHS).Peer reviewe

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.Paroxysmal Cerebral Disorder