103 research outputs found
Deformation of Small Compressed Droplets
We investigate the elastic properties of small droplets under compression.
The compression of a bubble by two parallel plates is solved exactly and it is
shown that a lowest-order expansion of the solution reduces to a form similar
to that obtained by Morse and Witten. Other systems are studied numerically and
results for configurations involving between 2 and 20 compressing planes are
presented. It is found that the response to compression depends on the number
of planes. The shear modulus is also calculated for common lattices and the
stability crossover between f.c.c.\ and b.c.c.\ is discussed.Comment: RevTeX with psfig-included figures and a galley macr
Ab initio calculations of optical properties of silver clusters: cross-over from molecular to nanoscale behavior
Electronic and optical properties of silver clusters were calculated using
two different \textit{ab initio} approaches: 1) based on all-electron
full-potential linearized-augmented plane-wave method and 2) local basis
function pseudopotential approach. Agreement is found between the two methods
for small and intermediate sized clusters for which the former method is
limited due to its all-electron formulation. The latter, due to non-periodic
boundary conditions, is the more natural approach to simulate small clusters.
The effect of cluster size is then explored using the local basis function
approach. We find that as the cluster size increases, the electronic structure
undergoes a transition from molecular behavior to nanoparticle behavior at a
cluster size of 140 atoms (diameter \,nm). Above this cluster size
the step-like electronic structure, evident as several features in the
imaginary part of the polarizability of all clusters smaller than
Ag, gives way to a dominant plasmon peak localized at
wavelengths 350\,nm 600\,nm. It is, thus, at this length-scale
that the conduction electrons' collective oscillations that are responsible for
plasmonic resonances begin to dominate the opto-electronic properties of silver
nanoclusters
Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis.
BACKGROUND: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. METHODS: We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first confirmed the association of these instruments with type 2 diabetes risk in a large diabetes genome-wide association study consortium. We then investigated their associations with breast cancer risk using individual-level data obtained from 98 842 cases and 83 464 controls of European descent in the Breast Cancer Association Consortium. RESULTS: All sets of instruments were associated with risk of type 2 diabetes. Associations with breast cancer risk were found for genetically predicted fasting insulin [odds ratio (OR) = 1.71 per standard deviation (SD) increase, 95% confidence interval (CI) = 1.26-2.31, p = 5.09 × 10-4], 2-h glucose (OR = 1.80 per SD increase, 95% CI = 1.3 0-2.49, p = 4.02 × 10-4), BMI (OR = 0.70 per 5-unit increase, 95% CI = 0.65-0.76, p = 5.05 × 10-19) and WHRadj BMI (OR = 0.85, 95% CI = 0.79-0.91, p = 9.22 × 10-6). Stratified analyses showed that genetically predicted fasting insulin was more closely related to risk of estrogen-receptor [ER]-positive cancer, whereas the associations with instruments of 2-h glucose, BMI and WHRadj BMI were consistent regardless of age, menopausal status, estrogen receptor status and family history of breast cancer. CONCLUSIONS: We confirmed the previously reported inverse association of genetically predicted BMI with breast cancer risk, and showed a positive association of genetically predicted fasting insulin and 2-h glucose and an inverse association of WHRadj BMI with breast cancer risk. Our study suggests that genetically determined obesity and glucose/insulin-related traits have an important role in the aetiology of breast cancer
Detectable clonal mosaicism and its relationship to aging and cancer
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases
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