Bioactivity and antimicrobial properties of chitosan-tobermorite membranes

Tobermorite (Ca5Si6O16(OH)2.4H2O) is a layered calcium silicate hydrate phase whose bioactivity and biocompatibility with respect to bone and dental tissues are documented. Chitosan is a biodegradable mucopolysaccharide derivative that has been evaluated as a tissue scaffold material for the in situ regeneration of bone and periodontal structures. Recent studies have shown that tobermorite-chitosan composites are potential candidates for use as biodegradable guided tissue regeneration (GTR) membranes [2,3]. During the GTR process, a membrane is used to isolate the exposed root surface from invasive epithelial and gingival tissues in order to enable the slow-growing periodontal ligament and hard tissues to regenerate. Resistance to potentially pathogenic oral bacteria is a highly desirable property of GTR membranes which are prone to biomaterial-centred infection. Silver (Ag+), copper (Cu2+) and gallium (Ga3+) ions are reported to confer antimicrobial activity when incorporated into bioactive materials [1,4,5]. In the present study, tobermorite was synthesised and ion-exchanged with Ag+, Cu2+ or Ga3+ ions. The in vitro bioactivity and antibacterial properties of solvent-cast tobermorite-chitosan composite membranes were then evaluated with respect to their potential use as GTR membranes to repair damaged periodontal structures

The transverse magnetic reflectivity minimum of metals

Copyright © 2008 Optical Society of America. This paper was published in Optics Express and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-10-7580 . Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law.Metal surfaces, which are generally regarded as excellent reflectors of electromagnetic radiation, may, at high angles of incidence, become strong absorbers for transverse magnetic radiation. This effect, often referred to as the pseudo-Brewster angle, results in a reflectivity minimum, and is most strongly evident in the microwave domain, where metals are often treated as perfect conductors. A detailed analysis of this reflectivity minimum is presented here and it is shown why, in the limit of very long wavelengths, metals close to grazing incidence have a minimum in reflectance given by (√2−1)2

High voltage coefficient piezoelectric materials and their applications

The piezoelectric dij coefficient is often regarded in materials science as the most important figure of merit of piezoelectric performance. For many applications, the piezoelectric gij coefficient which correlates to voltage output and sensitivity of a piezoelectric material can be considered of equal or increased importance, however is often an overlooked parameter in materials science literature. The aim of this review is to highlight the importance of this parameter and to provide insight into the mechanisms that drive a high piezoelectric voltage coefficient in single crystal, polycrystalline, and composite form. For bulk ceramics, special attention is given to tetragonal systems due to the availability of electrical and crystallographic data allowing for a clear structure-property relation. Orthorhombic and rhombohedral systems are mentioned and specific cases highlighted, however investigating structure-property relations is difficult due to the lack of crystallographic datasets. Composite materials have been the forefront of high gij piezoelectric materials over the decades and are therefore also considered in both ceramic-matrix and polymer-matrix form. An overview of applications in medical, energy, fishing and defence industries where a high gij is desirable are considered and the scientific and commercial considerations that must be made for the transition from laboratory to industry are discussed from the perspective of integrating new piezoelectric materials into sonar devices

HexPak and GradPak: variable-pitch dual-head IFUs for the WIYN 3.5m Telescope Bench Spectrograph

We describe the design, construction, and expected performance of two new fiber integral field units (IFUs) --- HexPak and GradPak --- for the WIYN 3.5m Telescope Nasmyth focus and Bench Spectrograph. These are the first IFUs to provide formatted fiber integral field spectroscopy with simultaneous sampling of varying angular scales. HexPak and GradPak are in a single cable with a dual-head design, permitting easy switching between the two different IFU heads on the telescope without changing the spectrograph feed: the two heads feed a variable-width double-slit. Each IFU head is comprised of a fixed arrangement of fibers with a range of fiber diameters. The layout and diameters of the fibers within each array are scientifically-driven for observations of galaxies: HexPak is designed to observe face-on spiral or spheroidal galaxies while GradPak is optimized for edge-on studies of galaxy disks. HexPak is a hexagonal array of 2.9 arcsec fibers subtending a 40.9 arcsec diameter, with a high-resolution circular core of 0.94 arcsec fibers subtending 6 arcsec diameter. GradPak is a 39 by 55 arcsec rectangular array with rows of fibers of increasing diameter from angular scales of 1.9 arcsec to 5.6 arcsec across the array. The variable pitch of these IFU heads allows for adequate sampling of light profile gradients while maintaining the photon limit at different scales.Comment: 10 pages, 4 figures, presented at SPIE, Astronomical Telescopes and Instrumentation, 1 - 6 July 2012, Amsterdam, Netherland

On the gamma-ray emission from the core of the Sagittarius dwarf galaxy

We use data from the Large Area Telescope onboard the Fermi gamma-ray space telescope (Fermi-LAT) to analyze the faint gamma-ray source located at the center of the Sagittarius (Sgr) dwarf spheroidal galaxy. In the 4FGL-DR3 catalog, this source is associated with the globular cluster, M54, which is coincident with the dynamical center of this dwarf galaxy. We investigate the spectral energy distribution and spatial extension of this source, with the goal of testing two hypotheses: (1) the emission is due to millisecond pulsars within M54, or (2) the emission is due to annihilating dark matter from the Sgr halo. For the pulsar interpretation, we consider a two-component model which describes both the lower-energy magnetospheric emission and possible high-energy emission arising from inverse Compton scattering. We find that this source has a point-like morphology at low energies, consistent with magnetospheric emission, and find no evidence for a higher-energy component. For the dark matter interpretation, we find that this signal favors a dark matter mass of $m_{\chi} = 29.6 \pm 5.8$ GeV and an annihilation cross section of $\sigma v = (2.1 \pm 0.59) \times 10^{-26} \,\text{cm}^3/$s for the $b \bar{b}$ channel (or $m_{\chi} = 8.3 \pm 3.8$ GeV and $\sigma v = (0.90 \pm 0.25) \times 10^{-26} \, \text{cm}^3/$s for the $\tau^+ \tau^-$ channel), when adopting a J-factor of $J=10^{19.6} \, \text{GeV}^2 \, \text{cm}^{-5}$. This parameter space is consistent with gamma-ray constraints from other dwarf galaxies and with dark matter interpretations of the Galactic Center Gamma-Ray Excess.Comment: 12 pages, 9 figures. To be submitted to MNRAS -- comments welcom

Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs)

The prostate is a site of high expression of serine proteinases including members of the kallikrein-related peptidase (KLK) family, as well as other secreted and membrane-anchored serine proteinases. It has been known for some time that members of this enzyme family elicit cellular responses by acting directly on cells. More recently, it has been recognised that for serine proteinases with specificity for cleavage after arginine and lysine residues (trypsin-like or tryptic enzymes) these cellular responses are often mediated by cleavage of members of the proteinase-activated receptor (PAR) family - a four member sub-family of G protein-coupled receptors. Here, we review the expression of PARs in prostate, the ability of prostatic trypsin-like KLKs and other prostate-expressed tryptic enzymes to cleave PARs, as well as the prostate cancer-associated consequences of PAR activation. In addition, we explore the dysregulation of trypsin-like serine proteinase activity through the loss of normal inhibitory mechanisms and potential interactions between these dysregulated enzymes leading to aberrant PAR activation, intracellular signalling and cancer-promoting cellular changes

Investigation of the phase bias in the short term interferograms

Interferometric Synthetic Aperture Radar (InSAR) is a powerful tool for monitoring ground deformation associated with earthquakes, volcanoes, landslides, and different anthropogenic activities. The accuracy of the estimated deformation depends on a number of parameters including tropospheric and ionospheric delays, unwrapping errors, phase decorrelation due to changes in scattering behavior and system noise. However, recently an additional source of phase noise has been identified [1], which is strongest in short-interval multi-looked interferograms and, unlike other sources of noise, leads to biased, non-zero loop closure phases. This is problematic for time-series analysis because short-interval interferograms may be the only ones that maintain coherence for some areas. In this study, we explore the characteristics of this phenomenon and propose a mitigation strategy

The functional role of producer diversity in ecosystems

Over the past several decades, a rapidly expanding field of research known as biodiversity and ecosystem functioning has begun to quantify how the world\u27s biological diversity can, as an independent variable, control ecological processes that are both essential for, and fundamental to, the functioning of ecosystems. Research in this area has often been justified on grounds that (1) loss of biological diversity ranks among the most pronounced changes to the global environment and that (2) reductions in diversity, and corresponding changes in species composition, could alter important services that ecosystems provide to humanity (e.g., food production, pest/disease control, water purification). Here we review over two decades of experiments that have examined how species richness of primary producers influences the suite of ecological processes that are controlled by plants and algae in terrestrial, marine, and freshwater ecosystems. Using formal meta-analyses, we assess the balance of evidence for eight fundamental questions and corresponding hypotheses about the functional role of producer diversity in ecosystems. These include questions about how primary producer diversity influences the efficiency of resource use and biomass production in ecosystems, how primary producer diversity influences the transfer and recycling of biomass to other trophic groups in a food web, and the number of species and spatial /temporal scales at which diversity effects are most apparent. After summarizing the balance of evidence and stating our own confidence in the conclusions, we outline several new questions that must now be addressed if this field is going to evolve into a predictive science that can help conserve and manage ecological processes in ecosystems