The Witt Ring of a Curve with Good Reduction over a Non-dyadic Local Field

In this work, we present a generalization to varieties and sheaves of the fundamental ideal of the Witt ring of a field by defining a sheaf of fundamental ideals $\tilde{I}$ and a sheaf of Witt rings $\tilde{W}$ in the obvious way. The Milnor conjecture then relates the associated graded of $\tilde{W}$ to Milnor K-theory and so allows the classical invariants of a bilinear space over a field to be extended to our setting using \'etale cohomology. As an application of these results, we calculate the Witt ring of a smooth curve with good reduction over a non-dyadic local field

Treatment Of Hypertension In The Elderly Patient

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111195/1/j.1532-5415.1954.tb00881.x.pd

Treatment Of Hypercholesterolemia With Aluminum Nicotinate*†

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111193/1/j.1532-5415.1962.tb03157.x.pd

CLINICAL PHARMACOLOGY OF BRETYLIUM TOSYLATE: PRELIMINARY OBSERVATIONS

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73174/1/j.1749-6632.1960.tb20087.x.pd

Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases

AbstractUnderstanding the mode of action for lipoxygenase (LOX) inhibitors is critical to determining their efficacy in the cell. The pseudoperoxidase assay is an important tool for establishing if a LOX inhibitor is reductive in nature, however, there have been difficulties identifying the proper conditions for each of the many human LOX isozymes. In the current paper, both the 234nM decomposition (UV) and iron-xylenol orange (XO) assays are shown to be effective methods of detecting pseudoperoxidase activity for 5-LOX, 12-LOX, 15-LOX-1 and 15-LOX-2, but only if 13-(S)-HPODE is used as the hydroperoxide substrate. The AA products, 12-(S)-HPETE and 15-(S)-HPETE, are not consistent hydroperoxide substrates since they undergo a competing transformation to the di-HETE products. Utilizing the above conditions, the selective 12-LOX and 15-LOX-1 inhibitors, probes for diabetes, stroke and asthma, are characterized for their inhibitory nature. Interestingly, ascorbic acid also supports the pseudoperoxidase assay, suggesting that it may have a role in maintaining the inactive ferrous form of LOX in the cell. In addition, it is observed that nordihydroguaiaretic acid (NDGA), a known reductive LOX inhibitor, appears to generate radical species during the pseudoperoxidase assay, which are potent inhibitors against the human LOX isozymes, producing a negative pseudoperoxidase result. Therefore, inhibitors that do not support the pseudoperoxidase assay with the human LOX isozymes, should also be investigated for rapid inactivation, to clarify the negative pseudoperoxidase result

Rate Coefficients for Reactions of Ethynyl Radical (C2H) With HCN and CH3CN: Implications for the Formation of Comples Nitriles on Titan

Rate coefficients for the reactions of C2H + HCN yields products and C2H + CH3CN yields products have been measured over the temperature range 262-360 K. These experiments represent an ongoing effort to accurately measure reaction rate coefficients of the ethynyl radical, C2H, relevant to planetary atmospheres such as those of Jupiter and Saturn and its satellite Titan. Laser photolysis of C2H2 is used to produce C2H, and transient infrared laser absorption is employed to measure the decay of C2H to obtain the subsequent reaction rates in a transverse flow cell. Rate constants for the reaction C2H + HCN yields products are found to increase significantly with increasing temperature and are measured to be (3.9-6.2) x 10(exp 13) cm(exp 3) molecules(exp -1) s(exp -1) over the temperature range of 297-360 K. The rate constants for the reaction C2H + CH3CN yields products are also found to increase substantially with increasing temperature and are measured to be (1.0-2.1) x 10(exp -12) cm(exp 3) molecules(exp -1) s(exp -1) over the temperature range of 262-360 K. For the reaction C2H + HCN yields products, ab initio calculations of transition state structures are used to infer that the major products form via an addition/elimination pathway. The measured rate constants for the reaction of C2H + HCN yields products are significantly smaller than values currently employed in photochemical models of Titan, which will affect the HC3N distribution