N,N′-Bis[4-(trifluoro­meth­yl)phen­yl]pyridine-2,6-dicarboxamide

In the title mol­ecule, C21H13F6N3O2, the pyridine ring forms dihedral angles of 1.7 (1) and 5.2 (1)° with the two benzene rings. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds and π⋯π inter­actions [centroid–centroid distance of 3.628 (3) Å between aromatic rings] link mol­ecules into stacks along the c axis. The two trifluoro­methyl groups are each rotationally disordered between two orientations, with occupancy ratios of 0.58 (1):0.42 (1) and 0.55 (1):0.45 (1)

Asca: less audio data is more insightful

Audio recognition in specialized areas such as birdsong and submarine acoustics faces challenges in large-scale pre-training due to the limitations in available samples imposed by sampling environments and specificity requirements. While the Transformer model excels in audio recognition, its dependence on vast amounts of data becomes restrictive in resource-limited settings. Addressing this, we introduce the Audio Spectrogram Convolution Attention (ASCA) based on CoAtNet, integrating a Transformer-convolution hybrid architecture, novel network design, and attention techniques, further augmented with data enhancement and regularization strategies. On the BirdCLEF2023 and AudioSet(Balanced), ASCA achieved accuracies of 81.2% and 35.1%, respectively, significantly outperforming competing methods. The unique structure of our model enriches output, enabling generalization across various audio detection tasks. Our code can be found at https://github.com/LeeCiang/ASCA.Comment: 6 pages,3 figure

Antiperovskite Li3OCl Superionic Conductor Films for Solid-State Li-Ion Batteries.

Antiperovskite Li3OCl superionic conductor films are prepared via pulsed laser deposition using a composite target. A significantly enhanced ionic conductivity of 2.0 × 10-4 S cm-1 at room temperature is achieved, and this value is more than two orders of magnitude higher than that of its bulk counterpart. The applicability of Li3OCl as a solid electrolyte for Li-ion batteries is demonstrated

System-level coupled modeling of piezoelectric vibration energy harvesting systems by joint finite element and circuit analysis

A practical piezoelectric vibration energy harvesting (PVEH) system is usually composed of two coupled parts: a harvesting structure and an interface circuit. Thus, it is much necessary to build system-level coupled models for analyzing PVEH systems, so that the whole PVEH system can be optimized to obtain a high overall efficiency. In this paper, two classes of coupled models are proposed by joint finite element and circuit analysis. The first one is to integrate the equivalent circuit model of the harvesting structure with the interface circuit and the second one is to integrate the equivalent electrical impedance of the interface circuit into the finite element model of the harvesting structure. Then equivalent circuit model parameters of the harvesting structure are estimated by finite element analysis and the equivalent electrical impedance of the interface circuit is derived by circuit analysis. In the end, simulations are done to validate and compare the proposed two classes of system-level coupled models. The results demonstrate that harvested powers from the two classes of coupled models approximate to theoretic values. Thus, the proposed coupled models can be used for system-level optimizations in engineering applications

Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat

<p>Abstract</p> <p>Background</p> <p>Many studies have found that stress before or during pregnancy is linked to an increased incidence of behavioural disorders in offspring. However, few studies have investigated hypothalamic-pituitary-adrenal (HPA) axis activity and the serotonergic system as a consequence of pregestational stress. In the present study, we investigated the effect of pre-gestational stress on HPA axis activity in maternal rats and their foetuses and examined whether changes in HPA axis activity of maternal rats produced functional changes in the serotonergic system in the brain of foetuses.</p> <p>Results</p> <p>We used the behavioural tests to assess the model of chronic unpredictable stress (CUS) in maternal rats. We found the activity in the open field and sucrose consumption was lower for rats with CUS than for the controls. Body weight but not brain weight was higher for control foetuses than those from the CUS group. Serum corticosterone and corticotrophin-releasing hormone levels were significantly higher for mothers with CUS before pregnancy and their foetuses than for the controls. Levels of 5-hydroxytryptamine (5-HT) were higher in the hippocampus and hypothalamus of foetuses in the CUS group than in the controls, and 5-hydroxyindoleacetic acid (5-HIAA) levels were lower in the hippocampus in foetuses in the CUS group than in the control group. Levels of 5-HIAA in the hypothalamus did not differ between foetuses in the CUS group and in the control group. The ratio of 5-HIAA to 5-HT was significantly lower for foetuses in the CUS group than in the control group. Levels of 5-HT1A receptor were significantly lower in the foetal hippocampus in the CUS group than in the control group, with no significant difference in the hypothalamus. The levels of serotonin transporter (SERT) were lower in both the foetal hippocampus and foetal hypothalamus in the CUS group than in the control group.</p> <p>Conclusions</p> <p>Our data demonstrate that pre-gestational stress alters HPA axis activity in maternal rats and their foetuses, which is associated with functional changes in 5-HT activity (5-HT, 5-HIAA and ratio of 5-HIAA to 5-HT), as well as the levels of the 5-HT1A receptor and SERT in the hippocampus and hypothalamus of foetuses.</p

Soulstyler: Using Large Language Model to Guide Image Style Transfer for Target Object

Image style transfer occupies an important place in both computer graphics and computer vision. However, most current methods require reference to stylized images and cannot individually stylize specific objects. To overcome this limitation, we propose the "Soulstyler" framework, which allows users to guide the stylization of specific objects in an image through simple textual descriptions. We introduce a large language model to parse the text and identify stylization goals and specific styles. Combined with a CLIP-based semantic visual embedding encoder, the model understands and matches text and image content. We also introduce a novel localized text-image block matching loss that ensures that style transfer is performed only on specified target objects, while non-target regions remain in their original style. Experimental results demonstrate that our model is able to accurately perform style transfer on target objects according to textual descriptions without affecting the style of background regions. Our code will be available at https://github.com/yisuanwang/Soulstyler.Comment: 5 pages,3 figures,ICASSP202

A Viral Mechanism for Inhibition of p300 and PCAF Acetyltransferase Activity

AbstractNucleosomal histone modification is believed to be a critical step in the activation of RNA polymerase II–dependent transcription. p300/CBP and PCAF histone acetyltransferases (HATs) are coactivators for several transcription factors, including nuclear hormone receptors, p53, and Stat1 α, and participate in transcription by forming an activation complex and by promoting histone acetylation. The adenoviral E1A oncoprotein represses transcriptional signaling by binding to p300/CBP and displacing PCAF and p/CIP proteins from the complex. Here, we show that E1A directly represses the HAT activity of both p300/CBP and PCAF in vitro and p300-dependent transcription in vivo. Additionally, E1A inhibits nucleosomal histone modifications by the PCAF complex and blocks p53 acetylation. These results demonstrate the modulation of HAT activity as a novel mechanism of transcriptional regulation

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

AbstractWe report here the identification of a novel cofactor, ACTR, that directly binds nuclear receptors and stimulates their transcriptional activities in a hormone- dependent fashion. ACTR also recruits two other nuclear factors, CBP and P/CAF, and thus plays a central role in creating a multisubunit coactivator complex. In addition, and unexpectedly, we show that purified ACTR is a potent histone acetyltransferase and appears to define a distinct evolutionary branch to this recently described family. Thus, hormonal activation by nuclear receptors involves the mutual recruitment of at least three classes of histone acetyltransferases that may act cooperatively as an enzymatic unit to reverse the effects of histone deacetylase shown to be part of the nuclear receptor corepressor complex

MRI signal intensity differentiation of brainstem encephalitis induced by Enterovirus 71: a classification approach for acute and convalescence stages

Additional file 3. After tick the segment region, Medflovan show the segmentation region of lesion