X-ray Data Analysis to Search for Magnetar Candidates in the Galactic Plane

We report on our Galactic plane searches for magnetars in the archival Chandra X-ray Observatory (CXO) data. We summarize the properties of known magnetars and use them to establish a procedure for magnetar searches. The procedure includes four steps: source finding, spectral characterization, optical counterpart checks, and period searches. We searched 1,282 archival CXO observations, found 32,838 X-ray sources, and selected 25 intriguing candidates using the developed procedure. Although we do not firmly identify a magnetar among them, we significantly reduced the number of targets in future magnetar searches to be done with better X-ray telescopes

A broadband X-ray study of the Rabbit pulsar wind nebula powered by PSR J1418-6058

We report on broadband X-ray properties of the Rabbit pulsar wind nebula (PWN) associated with the pulsar PSR J1418-6058 using archival Chandra and XMM-Newton data, and a new NuSTAR observation. NuSTAR data above 10 keV allowed us to detect the 110-ms spin period of the pulsar, characterize its hard X-ray pulse profile, and resolve hard X-ray emission from the PWN after removing contamination from the pulsar and other overlapping point sources. The extended PWN was detected up to $\sim$20 keV and is well described by a power-law model with a photon index $\Gamma\approx$2. The PWN shape does not vary significantly with energy, and its X-ray spectrum shows no clear evidence of softening away from the pulsar. We modeled the spatial profile of X-ray spectra and broadband spectral energy distribution in the radio to TeV band to infer the physical properties of the PWN. We found that a model with low magnetic field strength ($B\sim 10$ $\mu$G) and efficient diffusion ($D\sim 10^{27}$ cm$^2$ s$^{-1}$) fits the PWN data well. The extended hard X-ray and TeV emission, associated respectively with synchrotron radiation and inverse Compton scattering by relativistic electrons, suggests that particles are accelerated to very high energies ($\gtrsim500$ TeV), indicating that the Rabbit PWN is a Galactic PeVatron candidate.Comment: 21 pages, 10 figures. ApJ accepte

X-ray studies of the pulsar PSR J1420-6048 and its TeV pulsar wind nebula in the Kookaburra region

We present a detailed analysis of broadband X-ray observations of the pulsar PSR J1420-6048 and its wind nebula (PWN) in the Kookaburra region with Chandra, XMM-Newton, and NuSTAR. Using the archival XMM-Newton and new NuSTAR data, we detected 68 ms pulsations of the pulsar and characterized its X-ray pulse profile which exhibits a sharp spike and a broad bump separated by ~0.5 in phase. A high-resolution Chandra image revealed a complex morphology of the PWN: a torus-jet structure, a few knots around the torus, one long (~7') and two short tails extending in the northwest direction, and a bright diffuse emission region to the south. Spatially integrated Chandra and NuSTAR spectra of the PWN out to 2.5' are well described by a power law model with a photon index ${\Gamma} {\approx}$ 2. A spatially resolved spectroscopic study, as well as NuSTAR radial profiles of the 3--7 keV and 7--20 keV brightness, showed a hint of spectral softening with increasing distance from the pulsar. A multi-wavelength spectral energy distribution (SED) of the source was then obtained by supplementing our X-ray measurements with published radio, Fermi-LAT, and H.E.S.S. data. The SED and radial variations of the X-ray spectrum were fit with a leptonic multi-zone emission model. Our detailed study of the PWN may be suggestive of (1) particle transport dominated by advection, (2) a low magnetic-field strength (B ~ 5${\mu}$G), and (3) electron acceleration to ~PeV energies.Comment: 18 pages and 8 figures. Accepted for publication in Ap

Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance

Acknowledgments: We thank members of the Ming and Song laboratories for comments and suggestions, D. Johnson for technical support, and J. Schnoll for lab coordination. This work was supported by grants from the National Institutes of Health (NIH) (R01MH105128 and R35NS097370 to G.-L.M. and R37NS047344 to H.S.) and from the National Alliance for Research on Schizophrenia and Depression (NARSAD) to G.-L.M., H.S., and E.K. Author Contributions: E.K. and J.S contributed equally to this work. J.S. performed electrophysiological analysis and E.K. performed morphological analysis. Y.L. and K.-S.H. contributed to electrophysiology data collection, Y.G. and S.G. helped with some of the retrovirus production, and B.B. helped with rabies synaptic tracing. J.P., J.H.L., Q.H., W.L., and K.M.C. contributed to additional data collection. E.K., J.S., H.S., and G-L.M. designed the project and wrote the manuscript.Peer reviewedPublisher PD

Frequent Gene Amplification Predicts Poor Prognosis in Gastric Cancer

Gastric cancer is one of the most common malignancies worldwide. However, genetic alterations leading to this disease are largely unknown. Gene amplification is one of the most frequent genetic alterations, which is believed to play a major role in the development and progression of gastric cancer. In the present study, we identified three frequently amplified genes from 30 candidate genes using real-time quantitative PCR method, including ERBB4, C-MET and CD44, and further explored their association with clinicopathological characteristics and poor survival in a cohort of gastric cancers. Our data showed amplification of these genes was significantly associated with certain clinicopathological characteristics, particularly tumor differentiation and cancer-related death. More importantly, amplification of these genes was significantly related to worse survival, suggesting that these amplified genes may be significant predictors of poor prognosis and potential therapeutic targets in gastric cancer. Targeting these genes may thus provide new possibilities in the treatment of gastric cancer

A highly hydrophilic water-insoluble nanofiber composite as an efficient and easily-handleable adsorbent for the rapid adsorption of cesium from radioactive wastewater

Herein, we report a new Prussian blue nanoparticle (PBNPs) incorporated polyvinyl alcohol (PVA) composite nanofiber (c-PBNPs/PVA) for the rapid adsorption of cesium (Cs) from radioactive wastewater. Initially, various electrospinning parameters such as solvent, PVA wt%, PBNPs wt% and glutaraldehyde (GA) wt% were extensively optimized to obtain a better physicochemical property of the c-PBNPs/PVA. In order to improve the water insoluble nature of the PVA, post cross-linking was carried out for the c-PBNPs/PVA using glutaraldehyde (GA) and HCl vapor as the cross-linker and catalyst, respectively. SEM images revealed the smooth and continuous morphology of the c-PBNPs/PVA composite nanofibers with diameters of 200–300 nm and lengths up to several millimeters. TEM images confirmed homogeneous dispersion and good incorporation of PBNPs into the PVA matrix. The amorphous nature of the c-PBNPs/PVA was confirmed by the XRD analysis. FT-IR spectra showed successful cross-linking of PVA with GA. It was found that the prepared composite nanofiber is highly hydrophilic and water-insoluble. The c-PBNPs/PVA showed an excellent and faster Cs adsorption rate of 96% after only 100 min. These results are comparable to those previously reported. After the Cs adsorption test, the c-PBNPs/PVA composite nanofiber can be easily separated from the wastewater.ArticleRSC ADVANCES. 4(103):59571-59578 (2014)journal articl