Distributed Active Noise Control System Based on a Block Diffusion FxLMS Algorithm with Bidirectional Communication

Recently, distributed active noise control systems based on diffusion adaptation have attracted significant research interest due to their balance between computational complexity and stability compared to conventional centralized and decentralized adaptation schemes. However, the existing diffusion FxLMS algorithm employs node-specific adaptation and neighborhood-wide combination, and assumes that the control filters of neighbor nodes are similar to each other. This assumption is not true in practical applications, and it leads to inferior performance to the centralized controller approach. In contrast, this paper proposes a Block Diffusion FxLMS algorithm with bidirectional communication, which uses neighborhood-wide adaptation and node-specific combination to update the control filters. Simulation results validate that the proposed algorithm converges to the solution of the centralized controller with reduced computational burden

The consistency of invasive and non-invasive arterial blood pressure for the assessment of dynamic cerebral autoregulation in NICU patients

BackgroundStudies of the clinical application of dynamic cerebral autoregulation show considerable variations, and differences in blood pressure devices may be one of the reasons for this variation. Few studies have examined the consistency of invasive and non-invasive arterial blood pressure for evaluating cerebral autoregulation. We attempted to investigate the agreement between invasive and non-invasive blood pressure methods in the assessment of dynamic cerebral autoregulation with transfer function analysis.MethodsContinuous cerebral blood flow velocity and continuous invasive and non-invasive arterial blood pressure were simultaneously recorded for 15 min. Transfer function analysis was applied to derive the phase shift, gain and coherence function at all frequency bands from the first 5, 10, and 15 min of the 15-min recordings. The consistency was assessed with Bland–Altman analysis and intraclass correlation coefficient.ResultsThe consistency of invasive and noninvasive blood pressure methods for the assessment of dynamic cerebral autoregulation was poor at 5 min, slightly improved at 10 min, and good at 15 min. The values of the phase shift at the low-frequency band measured by the non-invasive device were higher than those measured with invasive equipment. The coherence function values measured by the invasive technique were higher than the values derived from the non-invasive method.ConclusionBoth invasive and non-invasive arterial blood pressure methods have good agreement in evaluating dynamic cerebral autoregulation when the recording duration reaches 15 min. The phase shift values measured with non-invasive techniques are higher than those measured with invasive devices. We recommend selecting the most appropriate blood pressure device to measure cerebral autoregulation based on the disease, purpose, and design

SARS-CoV-2 Nucleocapsid Protein Has DNA-Melting and Strand-Annealing Activities With Different Properties From SARS-CoV-2 Nsp13

Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world and has had a devastating impact on health and economy. The biochemical characterization of SARS-CoV-2 proteins is important for drug design and development. In this study, we discovered that the SARS-CoV-2 nucleocapsid protein can melt double-stranded DNA (dsDNA) in the 5′-3′ direction, similar to SARS-CoV-2 nonstructural protein 13. However, the unwinding activity of SARS-CoV-2 nucleocapsid protein was found to be more than 22 times weaker than that of SARS-CoV-2 nonstructural protein 13, and the melting process was independent of nucleoside triphosphates and Mg2+. Interestingly, at low concentrations, the SARS-CoV-2 nucleocapsid protein exhibited a stronger annealing activity than SARS-CoV-2 nonstructural protein 13; however, at high concentrations, it promoted the melting of dsDNA. These findings have deepened our understanding of the SARS-CoV-2 nucleocapsid protein and will help provide novel insights into antiviral drug development

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P interaction  = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

Promoting Creative Computing: origin, scope, research and applications

Human creativity needs improvement in contemporary society. Due to the fast development and pervasive utilisation, computing has been a good servant to support creativity. It is not only utilised to facilitate creativity research, but also leveraged to assist creative activities in everyday life. Up to now, people have never stopped exploring the great potentials of computing to facilitate human creativity. Various new concepts of computing are currently emerging, especially creative computing that inspires a novel approach to improving human creativity. This paper presents a comprehensive review of Creative Computing, including its origin, scope, research and applications

An architecture to support multi-node downloading of distributed virtual environment on grid.

We propose a three-layer framework and a Globus-based architecture of grid-enabled multi-node downloading mechanism to facilitate a flexible and scalable downloading large scale distributed virtual environments. In our proposed architecture, each grid node is regarded as a potential downloading service provider when available. The performance of downloading DVE is proportional to the number of grid nodes participated in the downloading task. A specific component, multi-node downloading (MND) is devised for supporting remote multi-thread downloading DVE based on Globus platform. MND consists in a multi-node downloading protocol and an adaptive multi-node downloading balancing (AMDB) algorithm. MND is deploying onto our developing "Virtual Zhuhai Campus of Jilin University". Initial experimental results show the feasibility and effectiveness of our approach

Web phishing detection based on page spatial layout similarity

Web phishing is becoming an increasingly severe security threat in the web domain. Effective and efficient phishing detection is very important for protecting web users from loss of sensitive private information and even personal properties. One of the keys of phishing detection is to efficiently search the legitimate web page library and to find those page that are the most similar to a suspicious phishing page. Most existing phishing detection methods are focused on text and/or image features and have paid very limited attention to spatial layout characteristics of web pages. In this paper, we propose a novel phishing detection method that makes use of the informative spatial layout characteristics of web pages. In particular, we develop two different options to extract the spatial layout features as rectangle blocks from a given web page. Given two web pages, with their respective spatial layout features, we propose a page similarity definition that takes into account their spatial layout characteristics. Furthermore, we build an R-tree to index all the spatial layout features of a legitimate page library. As a result, phishing detection based on the spatial layout feature similarity is facilitated by relevant spatial queries via the R-tree. A series of simulation experiments are conducted to evaluate our proposals. The results demonstrate that the proposed novel phishing detection method is effective and efficient. Povzetek: Opisana je detekcija spletnega ribarjenja na osnovi podobnosti strani.