BFT Hamiltonian embedding for SU(3) Skyrmion

We newly apply the Batalin, Fradkin and Tyutin (BFT) formalism to the SU(3) flavor Skyrmion model to investigate the Weyl ordering correction to the structure of the hyperfine splittings of strange baryons. On the other hand, the Berry phases and Casimir effects are also discussed.Comment: 14 pages, modified titl

Symplectic embedding and Hamilton-Jacobi analysis of Proca model

Following the symplectic approach we show how to embed the Abelian Proca model into a first-class system by extending the configuration space to include an additional pair of scalar fields, and compare it with the improved Dirac scheme. We obtain in this way the desired Wess-Zumino and gauge fixing terms of BRST invariant Lagrangian. Furthermore, the integrability properties of the second-class system described by the Abelian Proca model are investigated using the Hamilton-Jacobi formalism, where we construct the closed Lie algebra by introducing operators associated with the generalized Poisson brackets.Comment: 24 page

Flavor symmetry breaking effects on SU(3) Skyrmion

We study the massive SU(3) Skyrmion model to investigate the flavor symmetry breaking (FSB) effects on the static properties of the strange baryons in the framework of the rigid rotator quantization scheme combined with the improved Dirac quantization one. Both the chiral symmetry breaking pion mass and FSB kinetic terms are shown to improve $c$ the ratio of the strange-light to light-light interaction strengths and $\bar{c}$ that of the strange-strange to light-light.Comment: 12 pages, latex, no figure

Baryonic Response of Dense Holographic QCD

The response function of a homogeneous and dense hadronic system to a time-dependent (baryon) vector potential is discussed for holographic dense QCD (D4/D8 embedding) both in the confined and deconfined phases. Confined holographic QCD is an uncompressible and static baryonic insulator at large N_c and large \lambda, with a gapped vector spectrum and a massless pion. Deconfined holographic QCD is a diffusive conductor with restored chiral symmetry and a gapped transverse baryonic current. Similarly, dense D3/D7 is diffusive for any non-zero temperature at large N_c and large \lambda. At zero temperature dense D3/D7 exhibits a baryonic longitudinal visco-elastic mode with a first sound speed \lambda/\sqrt{3} and a small width due to a shear viscosity to baryon ratio \eta/n_B=\hbar/4. This mode is turned diffusive by arbitrarily small temperatures, a hallmark of holography.Comment: V2: 47 pages, 7 figures, references added, typos correcte

The Chiral Model of Sakai-Sugimoto at Finite Baryon Density

In the context of holographic QCD we analyze Sakai-Sugimoto's chiral model at finite baryon density and zero temperature. The baryon number density is introduced through compact D4 wrapping S^4 at the tip of D8-\bar{D8}. Each baryon acts as a chiral point-like source distributed uniformly over R^3, and leads a non-vanishing U(1)_V potential on the brane. For fixed baryon charge density n_B we analyze the bulk energy density and pressure using the canonical formalism. The baryonic matter with point like sources is always in the spontaneously broken phase of chiral symmetry, whatever the density. The point-like nature of the sources and large N_c cause the matter to be repulsive as all baryon interactions are omega mediated. Through the induced DBI action on D8-\bar{D8}, we study the effects of the fixed baryon charge density n_B on the pion and vector meson masses and couplings. Issues related to vector dominance in matter in the context of holographic QCD are also discussed.Comment: V3: 39 pages, 16 figures, minor corrections, version to appear in JHEP. V2: references added, typos correcte

Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies

AbstractMutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of major RPGR isoforms (RPGR1–19 and RPGRORF15), we have generated isoform-specific antibodies and examined their expression and localization in the retina. Using sucrose-gradient centrifugation, immunofluorescence and co-immunoprecipitation methods, we show that RPGR isoforms localize to distinct sub-cellular compartments in mammalian photoreceptors and associate with a number of cilia-centrosomal proteins. The RCC1-like domain of RPGR, which is present in all major RPGR isoforms, is sufficient to target it to the cilia and centrosomes in cultured cells. Our findings indicate that multiple isotypes of RPGR may perform overlapping yet somewhat distinct transport-related functions in photoreceptors

Constraint structure of O(3) nonlinear sigma model revisited

We study the constraint structure of the O(3) nonlinear sigma model in the framework of the Lagrangian, symplectic, Hamilton-Jacobi as well as the Batalin-Fradkin-Tyutin embedding procedure.Comment: 17 page

Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.

OBJECTIVE: [(11)C]Flumazenil ([(11)C]FMZ) positron emission tomography (PET) can be used as a measure of neuronal loss. The purpose of this study was to validate reference tissue kinetic modelling of [(11)C]FMZ PET within a group of patients with head injury. METHODS: Following earlier studies, the pons was used as the reference region. PET scans were performed on 16 controls and 11 patients at least 6 months following injury, each of whom also had arterial blood sampling to provide whole blood and metabolite-corrected plasma input functions. Regional non-displaceable binding potentials (BP(ND)) were calculated from five reference tissue models and compared to BP(ND) from arterial input models. For the patients, the regions included a peri-lesional region of interest (ROI). RESULTS: Total distribution volume of the pons was not significantly different between control and patient groups (P = 0.24). BP(ND) from all the reference tissue approaches correlated well with BP(ND) from the plasma input models for both controls (r (2) = 0.98-1.00; P < 0.001) and patients (r (2) = 0.99-1.00; P < 0.001). For the peri-lesional regions (n = 11 ROI values), the correlation was also high (r (2) = 0.91). CONCLUSIONS: These results indicate that reference tissue modelling with the pons as the reference region is valid for [(11)C]FMZ PET in head-injured patients at 6 months following injury within both normal appearing and peri-lesional brain regions

A New Large-Well 1024x1024 Si:As Detector for the Mid-Infrare

We present a description of a new 1024x1024 Si:As array designed for ground-based use from 5 - 28 microns. With a maximum well depth of 5e6 electrons, this device brings large-format array technology to bear on ground-based mid-infrared programs, allowing entry to the megapixel realm previously only accessible to the near-IR. The multiplexer design features switchable gain, a 256x256 windowing mode for extremely bright sources, and it is two-edge buttable. The device is currently in its final design phase at DRS in Cypress, CA. We anticipate completion of the foundry run in the beginning of 2006. This new array will enable wide field, high angular resolution ground-based follow up of targets found by space-based missions such as the Spitzer Space Telescope and the Widefield Infrared Survey Explorer (WISE).Comment: 8 pages, 9 figures, 2005 San Diego SPI

Supersymmetric quantum mechanics with nonlocal potentials

We consider supersymmetric quantum mechanical models with both local and nonlocal potentials. We present a nonlocal deformation of exactly solvable local models. Its energy eigenfunctions and eigenvalues are determined exactly. We observe that both our model Hamiltonian and its supersymmetric partner may have normalizable zero-energy ground states, in contrast to local models with nonperiodic or periodic potentials.Comment: 4 pages, REVTeX, Minor revisions for clarificatio