Improvement of RTLS Performance Using Recursive RF Active Echo Algorithm

When it comes to indoor Real-Time Location Systems (RTLS) for an Automatic Guided Vehicle (AGV), the most important factor is to minimize the location estimation error. In industrial sites, centimetre-level accuracy is required for the AGV. Since the duration for measuring the position of an AGV is slower than the speed of arriving RF signals, the margin of error inevitably becomes larger than in systems that use low-speed media such as ultrasonic waves. To minimize such errors, a short-range location estimation Recursive RF Active Echo (RRFAE) algorithm is presented. Increasing the time ratio by repeatedly and interactively reflecting the signal can reduce measurement error. That is, there is an effect of expanding the measurement distance by the number of iterations. We propose and implement a precise positioning algorithm in an indoor environment where many reflections exist. The error analysis of the RRFAE algorithm after hardware correction shows that the level of the RRFAE's errors is only one tenth that of an RTLS system that uses other RF signals

Effect of Uncertainty in Illness and Fatigue on Health-Related Quality of Life of Patients on Dialysis: A Cross-Sectional Correlation Study

This study aimed to determine the effect of uncertainty in illness and fatigue on the health-related quality of life of patients on dialysis. A community-based cross-sectional study was conducted among patients on hemodialysis (n = 80) and peritoneal dialysis (n = 81) in Korea. Data were collated using self-reported structured questionnaires. Multiple regression analysis was used to identify those factors affecting the physical and mental health-related quality of life of patients. Patients on peritoneal dialysis reported higher levels of fatigue (p < 0.001). Factors affecting the physical health-related quality of life of patients on dialysis were fatigue (p < 0.001), employment (p = 0.001), and exercise (p = 0.016), thus explaining the observed variance of 37%. Factors affecting mental health-related quality of life were fatigue (p < 0.001), uncertainty (p = 0.004), educational level (p = 0.005), and smoking (p = 0.035). To improve the health-related quality of life of patients on dialysis, clinicians should assess their fatigue levels and plan multidisciplinary interventions to manage it. In addition, education level and employment status should be considered, and tailored interventions should be provided to acquire positive coping strategies and health promotion behaviors to counter disease uncertainty

Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment. To understand this cross-talk, we analyzed the transcriptome of 91,103 unsorted single cells from 23 Korean and 6 Belgian patients. Cancer cells displayed transcriptional features reminiscent of normal differentiation programs, and genetic alterations that apparently fostered immunosuppressive microenvironments directed by regulatory T cells, myofibroblasts and myeloid cells. Intercellular network reconstruction supported the association between cancer cell signatures and specific stromal or immune cell populations. Our collective view of the cellular landscape and intercellular interactions in colorectal cancer provide mechanistic information for the design of efficient immuno-oncology treatment strategies.status: publishe