Wurstkammer specimens of the planktic foraminifer Neogloboquadrina pachyderma (sinistral): A new morphotype from the Arctic Ocean and the Weddell Sea

From two cores of the central Arctic Ocean and the Southern Ocean (Weddell Sea) a new morphotype of the planktic foraminifer Neogloboquadrina pachyderma (sinistral) (Ehrenberg) with "sausage" shaped final chambers (i.e. "Wurstkammer") is described. A comparison of these morphotypes in the two polar regions shows significant differences in shape and frequency during the last 70,000 years in the central Arctic Ocean and during the last 140,000 years in the Weddell Sea. In the central Arctic Ocean the frequency of wurstkammer specinlens call be correlated to that of the so-called kummerform specimens during the last 70,000 years; this correlation cannot be seen in a core from the Weddell Sea. The wurstkammer and kummerform specimens are interpreted as being end-members of a morphological progressional line. The abnormal chamber growth is probably an adaption to various environmental stress conditions found in the two polar regions during the last 70,000 in the Arctic and 140,000 years in the Antarctic, but the reasons for this abnormality are not yet fully understood

Multi-nomial and Bayes-statistical configural classification

Ein Verfahren zur Klassifikation von Pbn aufgrund individueller Abweichung von der Annahme wiederholter multinornialer Zufallsereignisse und aufgrund individueller maximaler Likelihood der Zugehörigkeit zu einer bestimmten Gruppe wird nebst Modelltest dargelegt. Als Anwendungsbeispiel wird über die Ergebnisse bei zwei denkbaren Klassifikationen in verschiedenen Therapiemotivationsgruppen berichtetThe author suggests a method and a "model test" for the classification of subjects on grounds on individual deviation from the assumption of repeated multi-nomial chance encounters and on grounds of individual maximallikelihood of membership in a certain group. The author reports on the results reached with two conceivable classifications into different therapy-motivation groups. (L. Canders) französisch: L'auteur presente - avec test-modele - un procede permettant de c1asser les sujets selon leur tendance individuelle a s'ecarter de la croyance aux evenements fortuits multinomiques repetes et selon la likelihood maximale individuelle d'appartenance a un groupe precis. En guise d'application, on relate les resultats dans le cas de deux classifications possibles dans deux groupes differents de motivation therapeutique. (J. Chanel

Alternativenart, persönliche Glückszahl und magisch animistische Begründungen von Entscheidungen bei Risiko

Durch Variation des Konfliktgehalts zwischen zwei Alternativen und damit der Begründbarkeit von Entscheidungen sollte geprüft werden, ob das Auftreten magisch-animistischer Begründungen bei Schulkindern nur Begründungsschwierigkeiten anzeigt und nicht magisch-animistisches Denken. Mit Hilfe einer erfragten Glückszahl beim Würfeln sollte außerdem die Validität des magisch-animistisehen Gehalts von derartigen Begründungen untersucht werden. Es zeigte sich bei 61 11jährigen Vpn, daß magisch-animistisch klassifizierte Antworten mit dem Konfliktgehalt der Alternativen zusammenhingen und bei eine Glückszahl besitzenden Vpn, die diese in den Entscheidungen berücksichtigen, häufiger vorkommen als bei Vpn zweier Vergleichsgruppen.By varying the conflict between two alternatives the difficulty to give s. th. as an adequate reason for one's decisions was manipulated. 61 subjects aged 11 were tested to show by that whether their magic-animistic reasons for decisions only indicate their inability in finding well-founded reasons or indicate vaIidely their magic-animistic thinking. By asking for the lucky pip of the child the validity of the magic-animistic content of such reasonings should be investigated too. The data showed that answers which are classifled as magic-animistic, are related to the conflict between the alternatives and are given more often by subjects who reported to have a lucky pip and who considered it in their decisions than by subjects of two control groups. Resume: Les auteurs se demandent si les expIications magico-ammlstes des ecoIiers revelent une difficulte a formuler des justifications rationnelles ou un mode de pensee reellement magico-animiste. En demandant aux enfants si et pourquoi ils ont un nombre-chance lorsgu'ils jouent avec un de a six points, les auteurs etudient la vaIidite du contenu magico- animiste des justifications enfantines. Dans un groupe d'enfants de 11 ans les reponses magico-animistes sont en relation a la fois avec le contenu conflictuel de la situation et avec la croyance a un nombre-chance personnel

Die Entwicklungspsychologie der Delikts- und Geschäftsfähigkeit : ein exemplarischer Beitrag zur Validität der zivilrechtlichen Altersgrenze des vollendeten siebenten Lebensjahres

No abstract availabl

Gefühlvolle/leibliche Körperlichkeit(en) in Die Philosophie im Boudoir (1795)

In ihrem Beitrag mit dem Titel Gefühlvolle/leibliche Körperlichkeit(en) in Die Philosophie im Boudoir (1795) widmet sich Laura Hommers der Frage nach der Materialität des Geschlechts (Judith Butler) und geht auf die von Barbara Duden initiierte Debatte ein, ob sich der Vorwurf einer ‚Entkörperung durch Verkörperung von Theorie‘ aufrechterhalten lässt. Um die Konstruktion der Butler’schen Materialität aufzuzeigen, werden sexuelle Tableaux von Marquis de Sades Die Philosophie im Boudoir untersucht. In diesen sexuellen Handlungen wird die Materialität durch die Neuinterpretation von erogenen Zonen sichtbar, welche gleichzeitig eine Vielfalt von Geschlechtsidentitäten und sexuellen Begehren aufzeigen. Laura Hommers greift dabei auf Paula Irene Villas Plädoyer für eine Leibperspektive in der Geschlechterforschung zurück und argumentiert, dass durch den körperlichen Leib und die Leibphänomenologie nach Hermann Schmitz eine Leibperspektive in den sexuellen Tableaux verhandelt werden kann, die zu einem Empfindungs- und Verhaltensprogramm führt. Daran anknüpfend argumentiert der Beitrag, dass die leiblichen Gefühle beziehungsweise Regungen, welche bei Marquis de Sade sprachlich (auf einer körperlichen Ebene) geäußert werden, sich durch vielseitige körperliche Ausdrücke manifestieren und so eine (anatomische) Materialität in die Untersuchung dieser Tableaux zurückgebracht werden kann

Factors contributing to conductance and outcome of specific immunotherapy: Data from the German National Health Interview and Examination Survey 1998

Background: Allergies are an increasingly relevant public health problem. Specific immunotherapy (sIT) is presently the only causal treatment option. This study aimed to assess the frequency and determinants of sIT use and factors associated with treatment outcome. Methods: A cross-sectional analysis based on data from the German National Health Interview and Examination Survey 1998. Results: 2727 (39.2%) of study participants reported physician-diagnosed allergic disease. Among these, 16.5% (n ¼ 296) stated to have undergone sIT. In this subset 43.4% (n ¼ 129) reported improvement of symptoms, 21.9% (n ¼ 65) had not changed, and 34.6% (n ¼ 102) had discontinued treatment. The majority of patients treated with sIT showed multiple allergic symptoms and sensitisations. Factors significantly correlated with sIT treatment in multivariable analyses included rhinitis, asthma, several sensitisations, higher social status and residence in larger cities. Rhinitis and neurodermatitis were positively, and food allergy was negatively associated with the completion of sIT. No factors predicting improvement due to sIT could retrospectively be identified. Conclusion: Treatment with sIT under ‘real life’ conditions does not exactly follow current clinical guideline recommendations. In addition, patients may be selected for IT by socio-demographic factors. Whether this contributes to considerable discontinuation rates and limited effectiveness as observed here, needs further investigation.Peer Reviewe

Adaptação do sistema de simulação Mydispense para o ensino da dispensação de medicamentos

TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Farmácia.Os profissionais da saúde devem possuir capacidade de lidar com diferentes situações na prática da atenção à saúde. Entretanto, os cursos de graduação, de forma geral, estruturam o processo formativo a partir da aquisição de conteúdos. As Diretrizes Nacionais da graduação em Farmácia, regulamentadas pela resolução CNE/CES N° 6 de outubro de 2017, instituiu que a formação deve promover as competências necessárias ao desenvolvimento do farmacêutico. Entre as competências esperadas, a dispensação de medicamentos, incluindo a clínica farmacêutica, é central no exercício profissional da Farmácia no âmbito da atenção à saúde. O ensino através de metodologias ativas vem contribuindo para estudantes de todas as áreas desenvolverem competências profissionais. As estratégias baseadas em simulação são capazes de proporcionar experiências colaborativas, em situações realistas e seguras, resultando em aprendizagem significativa. O MyDispense é um software de simulação da dispensação de medicamentos, que vem contribuindo, em todo o mundo, para implementação de modelos pedagógicos eficazes no desenvolvimento das competências dos futuros farmacêuticos. Portanto, este estudo objetiva contribuir com o desenvolvimento de um modelo experiencial de ensino por simulação da prática profissional de dispensação de medicamentos no Sistema Único de Saúde, e analisar sua aplicabilidade na aprendizagem de estudantes do Curso de Farmácia. O percurso metodológico deste trabalho foi constituído pela elaboração de casos para compor as simulações no MyDispense, a proposição de um curso com estudantes do Curso de Farmácia da UFSC, e a utilização da simulação proposta pelos estudantes, e a mensuração da satisfação como indicador da aplicabilidade do recurso educacional. Os resultados demonstraram a utilidade do MyDispense para o desenvolvimento de competências relacionadas à dispensação, permitindo melhor entendimento dos processos da dispensação a partir da aprendizagem considerando os próprios erros. A adaptação do MyDispense precisa ser articulada às experiências dos estudantes com Farmácia Comunitária, de forma a proporcionar contribuições para a aprendizagem de forma contextualizada às situações específicas

Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone 1 receptor

Parathyroid hormone 1 receptor (PTH1R) is a member of the class B family of G protein-coupled receptors, which are characterized by a large extracellular domain required for ligand binding. We have previously shown that the extracellular domain of PTH1R is subject to metalloproteinase cleavage in vivo that is regulated by ligand-induced receptor trafficking and leads to impaired stability of PTH1R. In this work, we localize the cleavage site in the first loop of the extracellular domain using amino-terminal protein sequencing of purified receptor and by mutagenesis studies. We further show, that a receptor mutant not susceptible to proteolytic cleavage exhibits reduced signaling to G(s) and increased activation of G(q) compared to wild-type PTH1R. These findings indicate that the extracellular domain modulates PTH1R signaling specificity, and that its cleavage affects receptor signaling

Toward a molecular profile of self-representation

Feeling embodiment over our body or body part has a major role in the understanding of the self and control of self-actions. Even though it is crucial in our daily life, embodiment is not an homogenous phenotype across population, as quantified by implicit and explicit measures (i.e., neuroimaging or self-reports). Studies have shown differences in neuropathological conditions compared to healthy controls, but also across healthy individuals. We discuss examples of self-perception differences, and the molecular origin of embodiment, focusing on clinical cases, during the first and second section. We then discuss two important questions in this molecular-to-embodiment relationship: (i) which are the molecular levels (and their associated techniques) that can be relevant to embodiment, and (ii) which are the most adequate experiments to correlate molecular profiles and embodiment quantification across individuals. Potential answers for both questions will be outlined during the third and fourth sections, respectively, in order to design a framework to study the molecular profile of body embodiment